Protein Alignment PTPN3 and Ptpn3

DIOPT Version :10

• Sequence 1: XP_011517190.1
• Gene: PTPN3 / 5774
• HGNCID: 9655
• Length: 934
• Species: Homo sapiens
• Sequence 2: XP_006538160.1
• Gene: Ptpn3 / 545622
• MGIID: 105307
• Length: 935
• Species: Mus musculus
• Alignment Length: 935
• Identity: 854/935 - (91%)
• Similarity: 895/935 - (95%)
• Gaps: 1/935 - (0%)

Human     1 MVEQEGLSCGHPPE-NCYSAIVMTSRLRALGGRINNIRTSELPKEKTRSEVICSIHFLDGVVQTF 64
            ||||||:....||| |.|||.|||||||||||||||.||||||||||||||||||.||||:||||
Mouse     1 MVEQEGIPPRGPPEDNRYSAAVMTSRLRALGGRINNTRTSELPKEKTRSEVICSIRFLDGLVQTF 65

Human    65 KVTKQDTGQVLLDMVHNHLGVTEKEYFGLQHDDDSVDSPRWLEASKAIRKQLKGGFPCTLHFRVR 129
            ||.|||.||.||||.:.||||||||||||||.||.|||||||||||.:|||||||||||||||||
Mouse    66 KVNKQDLGQSLLDMAYGHLGVTEKEYFGLQHGDDPVDSPRWLEASKPLRKQLKGGFPCTLHFRVR 130

Human   130 FFIPDPNTLQQEQTRHLYFLQLKMDICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSD 194
            :||||||||||||||||||||||||:||||||||||||||||||||||||||:||||||||||:|
Mouse   131 YFIPDPNTLQQEQTRHLYFLQLKMDVCEGRLTCPLNSAVVLASYAVQSHFGDFNSSIHHPGYLAD 195

Human   195 SHFIPDQNEDFLTKVESLHEQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIAS 259
            |.||||||:|||:||||||||||||||||||||||||||||||||||||.|||||||||||||||
Mouse   196 SQFIPDQNDDFLSKVESLHEQHSGLKQSEAESCYINIARTLDFYGVELHGGRDLHNLDLMIGIAS 260

Human   260 AGVAVYRKYICTSFYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVE 324
            ||:||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   261 AGIAVYRKYICTSFYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVE 325

Human   325 HHTFFQAKKLLPQEKNVLSQYWTMGSRNTKKSVNNQYCKKVIGGMVWNPAMRRSLSVEHLETKSL 389
            ||:||||||||||||||||||||:||||.||||||||||||||||||||.||||||||.||||||
Mouse   326 HHSFFQAKKLLPQEKNVLSQYWTLGSRNPKKSVNNQYCKKVIGGMVWNPVMRRSLSVERLETKSL 390

Human   390 PSRSPPITPNWRSPRLRHEIRKPRHSSADNLANEMTYITETEDVFYTYKGSLAPQDSDSEVSQNR 454
            ||||||||||||||||||||||||||||||||||||||||||||||||||.|:|:|||||||||.
Mouse   391 PSRSPPITPNWRSPRLRHEIRKPRHSSADNLANEMTYITETEDVFYTYKGPLSPKDSDSEVSQNH 455

Human   455 SPHQESLSENNPAQSYLTQKSSSSVSPSSNAPGSCSPDGVDQQLLDDFHRVTKGGSTEDASQYYC 519
            |||:|||||||||||.||||||||||||||||||||||||||:.|:|:|:|||||..||||||||
Mouse   456 SPHRESLSENNPAQSCLTQKSSSSVSPSSNAPGSCSPDGVDQRFLEDYHKVTKGGFVEDASQYYC 520

Human   520 DKNDNGDSYLVLIRITPDEDGKFGFNLKGGVDQKMPLVVSRINPESPADTCIPKLNEGDQIVLIN 584
            ||:|:||.|||||||||||:|:|||||||||||||||||||||||||||||:|||||||||||||
Mouse   521 DKSDDGDGYLVLIRITPDEEGRFGFNLKGGVDQKMPLVVSRINPESPADTCMPKLNEGDQIVLIN 585

Human   585 GRDISEHTHDQVVMFIKASRESHSRELALVIRRRAVRSFADFKSEDELNQLFPEAIFPMCPEGGD 649
            |||||||||||||||||||||||||||||||||:||||.|:.:|||||:||||||:||.||||||
Mouse   586 GRDISEHTHDQVVMFIKASRESHSRELALVIRRKAVRSLAEIRSEDELSQLFPEAMFPACPEGGD 650

Human   650 TLEGSMAQLKKGLESGTVLIQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGNE 714
            :|||||..|||||||||||||||||||||||||::||||||||||||||||||||||||||||||
Mouse   651 SLEGSMELLKKGLESGTVLIQFEQLYRKKPGLAVSFAKLPQNLDKNRYKDVLPYDTTRVLLQGNE 715

Human   715 DYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYW 779
            |||||||||||:|||||||||||||||||:||||||||||||||||:||||||||||||||||||
Mouse   716 DYINASYVNMEMPAANLVNKYIATQGPLPNTCAQFWQVVWDQKLSLVVMLTTLTERGRTKCHQYW 780

Human   780 PDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLE 844
            |||||:|:||.||||||:|||||||||||||||||:|||||||||||||||||||||||||||||
Mouse   781 PDPPDIMDHGIFHIQCQTEDCTIAYVSREMLVTNTETGEEHTVTHLQYVAWPDHGVPDDSSDFLE 845

Human   845 FVNYVRSLRVDSEPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTS 909
            ||.||||||||.||.|||||||||||||||||||||||.|||||:||||||||||||||||||||
Mouse   846 FVKYVRSLRVDGEPALVHCSAGIGRTGVLVTMETAMCLIERNLPVYPLDIVRKMRDQRAMMVQTS 910

Human   910 SQYKFVCEAILRVYEEGLVQMLDPS 934
            ||||||||||||||||||||.||||
Mouse   911 SQYKFVCEAILRVYEEGLVQRLDPS 935

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PTPN3	XP_011517190.1	B41	52..243	CDD:214604	171/190 (90%)
		FERM_C_PTPN4_PTPN3_like	237..330	CDD:270010	89/92 (97%)
		PDZ_PTPN3-4-like	527..616	CDD:467190	84/88 (95%)
		PTPc-N3	652..925	CDD:350448	255/272 (94%)
Ptpn3	XP_006538160.1	B41	53..244	CDD:214604	171/190 (90%)
		FERM_C_PTPN4_PTPN3_like	238..331	CDD:270010	89/92 (97%)
		PDZ_PTPN3-4-like	528..617	CDD:467190	84/88 (95%)
		PTPc-N3	653..926	CDD:350448	255/272 (94%)