Protein Alignment PTPN3 and ptpn3

DIOPT Version :10

• Sequence 1: XP_011517190.1
• Gene: PTPN3 / 5774
• HGNCID: 9655
• Length: 934
• Species: Homo sapiens
• Sequence 2: XP_687930.5
• Gene: ptpn3 / 407635
• ZFINID: ZDB-GENE-030131-2934
• Length: 839
• Species: Danio rerio
• Alignment Length: 910
• Identity: 494/910 - (54%)
• Similarity: 629/910 - (69%)
• Gaps: 83/910 - (9%)

Human    22 MTSRLRALGGRINNIRTSELPK--EKTRSEVICSIHFLDGVVQTFKVTKQDTGQVLLDMVHNHLG 84
            |||....||.:|..:..::|.|  ...||.::|.:.|.||..|.|.|.|.|.|.:|.|:...||.
Zfish     1 MTSPWCMLGNKITALGRADLSKHTHMPRSGLLCLVLFPDGTTQNFTVNKHDAGHLLFDLACEHLN 65

Human    85 VTEKEYFGLQHDDDSVDSPRWLEASKAIRKQLKGGFPCTLHFRVRFFIPDPNTLQQEQTRHLYFL 149
            :.||:||.:|..:|:..|||||:.:|..:|||||..|..|.|||||||.|||:||.|||||.|||
Zfish    66 IVEKQYFSMQISEDTSSSPRWLDPNKPFKKQLKGSPPFFLMFRVRFFISDPNSLQHEQTRHFYFL 130

Human   150 QLKMDICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESLHE 214
            |::.|||||||.|||:||||||||:|||..||||... ..||||.:||||:|:::||.||||||.
Zfish   131 QIRKDICEGRLKCPLSSAVVLASYSVQSELGDYNPET-PTGYLSKTHFIPEQDQEFLLKVESLHP 194

Human   215 QHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTSFYPWVNI 279
            ||.||.||:||.||:|.|||||.||||||..:|..|..:.:||.|.|||::...||:||:||:||
Zfish   195 QHKGLSQSDAELCYLNTARTLDLYGVELHHAQDASNPAVWVGITSGGVALFCHLICSSFFPWINI 259

Human   280 LKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKKLLPQEKNVLSQ 344
            :|||||||:||:|.|:|..|...|:|:.:|.|.|:|||||:|||:||||:..|.
Zfish   260 IKISFKRKRFFVHLRRKHGELGHHVVSLSMPNSRACKNLWRSCVDHHTFYNRKP----------- 313

Human   345 YWTMGSRNTKKSVNNQYCKKVIGGMVWNPAMRRSLSVEHLETKSLPSRSPPITPNWRSPRLRHEI 409
                 |.:..|..:....:|::|..:.|| |.||.|||.||||||||||||.||||||||:||:.
Zfish   314 -----SHSASKLSSIPLYRKLVGEQMLNP-MVRSSSVEQLETKSLPSRSPPNTPNWRSPRVRHDF 372

Human   410 RKPRHSSADNLANEMTYITETEDVFYTYKGSLAPQDSDSEVSQNRSPHQESLSENNPAQSYLTQK 474
            |.||.||.|||.|||:|:||:|||||||                |.|.:|             ::
Zfish   373 RNPRPSSVDNLTNEMSYVTESEDVFYTY----------------RKPQEE-------------ER 408

Human   475 SSSSVSPSSNAPGSCSPDGVDQQLLDDFHRVTKGGSTEDASQYYCDKNDNGDSYLVLIRITPDED 539
            .|.|.|..                 ||.       :.|:...:..||:...|..|:|:||:||:|
Zfish   409 RSGSWSHG-----------------DDI-------TIEEDDLHVWDKSVTADGDLLLVRISPDQD 449

Human   540 GKFGFNLKGGVDQKMPLVVSRINPESPADTCIPKLNEGDQIVLINGRDISEHTHDQVVMFIKASR 604
            ||||||:||||||||||.:|.:|..|||..|:|.|.||||::||||||||||||.||||||||||
Zfish   450 GKFGFNVKGGVDQKMPLAISHVNLASPAGRCVPPLMEGDQVLLINGRDISEHTHQQVVMFIKASR 514

Human   605 ESHSRELALVIRRRAVRSFADFKSED--ELNQLFPEAIFPMCPE-GGDTLEGSMAQLKKGLESGT 666
            ||||:||||::||:.|    ..:.|.  :|....|..|.|:... .|:|||.|||:|:|||.:||
Zfish   515 ESHSKELALLVRRKGV----SLRVEPTLQLGLTLPGEISPLSTHPSGETLEESMARLEKGLVTGT 575

Human   667 VLIQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQ-GNEDYINASYVNMEIPAAN 730
            :|:.||:|||||.|:.::.||..:|:||||||||||||.|||:|| ..:||||||:|..|  .|.
Zfish   576 LLLHFEKLYRKKEGMLMSCAKQSENMDKNRYKDVLPYDITRVVLQEEGDDYINASHVKTE--PAG 638

Human   731 LVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQC 795
            .|.:|||.||||||||..||:.||:|.:::|:||||||||||||||||||.||:|.::|...:.|
Zfish   639 CVLQYIAAQGPLPHTCTHFWRSVWEQDVNVIIMLTTLTERGRTKCHQYWPHPPEVRDYGYLQVCC 703

Human   796 QSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVL 860
            .||:|.:|||:|::.:||||:|::.::||||||||||||||:||||||:||..|||:|.:|.|::
Zfish   704 HSEECNLAYVTRQLTLTNTQSGQQRSITHLQYVAWPDHGVPEDSSDFLDFVKSVRSMRQESVPLM 768

Human   861 VHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYEE 925
            |||||||||||||:||||||.|.|:..|:|||:::..||:||||:||||.|:.||||||||||.|
Zfish   769 VHCSAGIGRTGVLITMETAMTLMEKEKPVYPLEVITLMREQRAMLVQTSCQFTFVCEAILRVYRE 833

Human   926  925
            Zfish   834  833

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PTPN3	XP_011517190.1	B41	52..243	CDD:214604	116/190 (61%)
		FERM_C_PTPN4_PTPN3_like	237..330	CDD:270010	52/92 (57%)
		PDZ_PTPN3-4-like	527..616	CDD:467190	65/88 (74%)
		PTPc-N3	652..925	CDD:350448	175/273 (64%)
ptpn3	XP_687930.5	B41	33..223	CDD:214604	116/190 (61%)
		PH-like	217..309	CDD:473070	51/91 (56%)
		PDZ_PTPN3-4-like	437..526	CDD:467190	65/88 (74%)
		PTP_DSP_cys	561..833	CDD:475123	175/273 (64%)