Protein Alignment PTPN3 and Ptpn3

DIOPT Version :10

• Sequence 1: XP_011517190.1
• Gene: PTPN3 / 5774
• HGNCID: 9655
• Length: 934
• Species: Homo sapiens
• Sequence 2: XP_001059757.1
• Gene: Ptpn3 / 362524
• RGDID: 1311363
• Length: 1018
• Species: Rattus norvegicus
• Alignment Length: 925
• Identity: 844/925 - (91%)
• Similarity: 882/925 - (95%)
• Gaps: 3/925 - (0%)

Human    13 PE---NCYSAIVMTSRLRALGGRINNIRTSELPKEKTRSEVICSIHFLDGVVQTFKVTKQDTGQV 74
            ||   :.|||.||||||||||||||||||||||||||||||.|||.||||:||||||.|||.||.
  Rat    94 PESQAHSYSAAVMTSRLRALGGRINNIRTSELPKEKTRSEVTCSIRFLDGLVQTFKVNKQDLGQS 158

Human    75 LLDMVHNHLGVTEKEYFGLQHDDDSVDSPRWLEASKAIRKQLKGGFPCTLHFRVRFFIPDPNTLQ 139
            ||||.:.||||||||||||||.||.|||||||||||.:|||||||.||.||||||:|||||||||
  Rat   159 LLDMAYGHLGVTEKEYFGLQHGDDPVDSPRWLEASKPLRKQLKGGLPCILHFRVRYFIPDPNTLQ 223

Human   140 QEQTRHLYFLQLKMDICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNED 204
            |||||||||||||||:|||||||||||||||||||||||.||:||||||||||:||.||||||:|
  Rat   224 QEQTRHLYFLQLKMDVCEGRLTCPLNSAVVLASYAVQSHIGDFNSSIHHPGYLADSQFIPDQNDD 288

Human   205 FLTKVESLHEQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYI 269
            ||:||||||||||||||||||||||||||||||||||||.|||||||||||||||||:|||||||
  Rat   289 FLSKVESLHEQHSGLKQSEAESCYINIARTLDFYGVELHGGRDLHNLDLMIGIASAGIAVYRKYI 353

Human   270 CTSFYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKKL 334
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||:|||||||
  Rat   354 CTSFYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHSFFQAKKL 418

Human   335 LPQEKNVLSQYWTMGSRNTKKSVNNQYCKKVIGGMVWNPAMRRSLSVEHLETKSLPSRSPPITPN 399
            |||||||||||||:||||.||||||||||||||||||||.||||||||.||||||||||||||||
  Rat   419 LPQEKNVLSQYWTLGSRNPKKSVNNQYCKKVIGGMVWNPVMRRSLSVERLETKSLPSRSPPITPN 483

Human   400 WRSPRLRHEIRKPRHSSADNLANEMTYITETEDVFYTYKGSLAPQDSDSEVSQNRSPHQESLSEN 464
            ||||||||||||||||||||||||||||||||||||||||||:|:|||||||||.|||:.|||||
  Rat   484 WRSPRLRHEIRKPRHSSADNLANEMTYITETEDVFYTYKGSLSPKDSDSEVSQNHSPHRGSLSEN 548

Human   465 NPAQSYLTQKSSSSVSPSSNAPGSCSPDGVDQQLLDDFHRVTKGGSTEDASQYYCDKNDNGDSYL 529
            |||||.|||||||||||.||||||.||||||||.|:|:|:||||||.|:||||||||||:||.||
  Rat   549 NPAQSCLTQKSSSSVSPCSNAPGSFSPDGVDQQFLEDYHKVTKGGSIEEASQYYCDKNDDGDGYL 613

Human   530 VLIRITPDEDGKFGFNLKGGVDQKMPLVVSRINPESPADTCIPKLNEGDQIVLINGRDISEHTHD 594
            ||||||||::|:|||||||||||||||||||||||||||||:|||||||||||||||||||||||
  Rat   614 VLIRITPDKEGRFGFNLKGGVDQKMPLVVSRINPESPADTCMPKLNEGDQIVLINGRDISEHTHD 678

Human   595 QVVMFIKASRESHSRELALVIRRRAVRSFADFKSEDELNQLFPEAIFPMCPEGGDTLEGSMAQLK 659
            |||||||||||||||||||||||:||||.|:.:|||||:||||||:||.||||||:|||||..||
  Rat   679 QVVMFIKASRESHSRELALVIRRKAVRSLAEIRSEDELSQLFPEAMFPACPEGGDSLEGSMELLK 743

Human   660 KGLESGTVLIQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNM 724
            |||||||||||||||||||||||:|||||||||||||||||||||||||||||||||||||||||
  Rat   744 KGLESGTVLIQFEQLYRKKPGLAVTFAKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNM 808

Human   725 EIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNHG 789
            ||||||||||||||||||||||||||||||||||||:|||||||||||||||||||||||:|:||
  Rat   809 EIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLVVMLTTLTERGRTKCHQYWPDPPDIMDHG 873

Human   790 GFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRV 854
            .||||||:|||||||||||||||||:|||||||||||||||||||||||||||||||.|||||||
  Rat   874 IFHIQCQAEDCTIAYVSREMLVTNTETGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVKYVRSLRV 938

Human   855 DSEPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAI 919
            ..||.|||||||||||||||||||||||.|||||:||||||||||||||||||||||||||||||
  Rat   939 GGEPALVHCSAGIGRTGVLVTMETAMCLIERNLPVYPLDIVRKMRDQRAMMVQTSSQYKFVCEAI 1003

Human   920 LRVYEEGLVQMLDPS 934
            ||||||||||.||||
  Rat  1004 LRVYEEGLVQTLDPS 1018

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PTPN3	XP_011517190.1	B41	52..243	CDD:214604	168/190 (88%)
		FERM_C_PTPN4_PTPN3_like	237..330	CDD:270010	89/92 (97%)
		PDZ_PTPN3-4-like	527..616	CDD:467190	83/88 (94%)
		PTPc-N3	652..925	CDD:350448	257/272 (94%)
Ptpn3	XP_001059757.1	B41	135..327	CDD:214604	168/191 (88%)
		FERM_C_PTPN4_PTPN3_like	321..414	CDD:270010	89/92 (97%)
		PDZ_PTPN3-4-like	611..700	CDD:467190	83/88 (94%)
		PTPc-N3	736..1009	CDD:350448	257/272 (94%)