DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ANKRD36B and Poteg

DIOPT Version :9

Sequence 1:	NP_001380868.1	Gene:	ANKRD36B / 57730	HGNCID:	29333	Length:	1353	Species:	Homo sapiens
Sequence 2:	XP_038950658.1	Gene:	Poteg / 364620	RGDID:	1359470	Length:	1039	Species:	Rattus norvegicus

Alignment Length:	1134	Identity:	278/1134 - (24%)
Similarity:	457/1134 - (40%)	Gaps:	296/1134 - (26%)

- Green bases have known domain annotations that are detailed below.

Human    11 FPHYYIKPYHLKRIHRAVLRGNLEKLKYLL-LTYYDANKRDRKERTALHLACATGQPEMVHLLVS 74
            :|.|:.....|..|||....|:..:::.|: |.....:.||||:|||||.||..|:..:|.:||:
  Rat    38 YPKYHTTYRPLGHIHRVAAEGDAAQMEILITLGQCSVSDRDRKDRTALHFACVYGRLPVVTVLVN 102

Human    75 RRCELNLCDREDRTPLIKAVQLRQEACATLLLQNGADPNITDVFGRTALHYAVYNEDTSMIEKLL 139
            ..||::..|:...|||||:||..::.||||||::|||||:.|..|.:||||||||....|:..||
  Rat   103 NNCEIDAFDKNHITPLIKSVQCWKQKCATLLLEHGADPNVIDSSGNSALHYAVYNGHEEMVALLL 167

Human   140 SHGTNIEECSKNEYQPLLLAVSRRKVKMVEFLLKKKANVNAIDYLGRSALILAVTLGEKDIVILL 204
            .:..|||:.:|:.:.|||||:..::|::.|.|::..|:|:.:|.|.|:.||.|:..|.|.:.:.|
  Rat   168 QYKANIEQKTKDGFTPLLLALREKRVEVAELLVRMGADVHVVDELQRNTLIYAIRCGSKGLAVSL 232

Human   205 LQHNIDVFSRDVYGKLAEDYASEAE---NRVIFDLIYE---YKRKRYE-DLPINSNPVSPQKQRA 262
            |:..||.|.:||:|..|..||.|..   .:.:.|  :|   :.||..| :|.:..|   |....|
  Rat   233 LKKGIDFFYKDVFGWTALRYAIEGHCTFRQTLLD--FEENLHSRKENEPELEVEPN---PSCILA 292

Human   263 EKATSDDKDSVSNIATEIKEGPISGTVSSQKQPAEKATSDEKDSVSNIATEIKEGQQSGTVSPQK 327
            |:..:.| ||::.:::.:  .|::..:         |..||::|....:....|.......||
  Rat   293 EQVDAGD-DSLARVSSCL--SPVTPVL---------ALKDEENSRHTGSNSESEPPNCSGNSP-- 343

Human   328 QSAQKVIFKKKVSLLNIAT-RIMGGGKSGTVSS--QKQPASKTASDKTDSALNTATEIKDGLQCG 389
                            .|| :|.|.....||.:  :|.|:||:|::..||..|.|.|     :..
  Rat   344 ----------------AATDKIFGNRGKRTVEAWVEKDPSSKSATEMRDSVTNEAVE-----RIE 387

Human   390 TVSSQKQQALKATTDEEG-----------SVSNIATEIKDGEKSG--------TVSSQKKPALKA 435
            ..:|..:..|:..:.|||           |......:||....||        .::.|.|
  Rat   388 LFTSTSEPELELMSIEEGISDESENDQPLSELEHLPQIKVEHLSGAGYQVEKININGQMK----- 447

Human   436 TSDEKDSFSNITREKKDGEISRTVSSQKPPALKATSVKEDSVLNIAREKKDGEKSRTVSF----E 496
            .|||:.:......:.||.......:::..|..|  .|:.|..:.:..:.:..:| ||:..    |
  Rat   448 GSDEEYAQLTTPTDMKDPVSKEPWTTKNAPTFK--PVEADLEVALKEDHRFDDK-RTIQSLRIRE 509

Human   497 QPPGLKATRDEKDSLLNIARGKKDGEKTRR---VSSHKQPSLKATSDKEDSVPNMATETKDEQIS 558
            .||.....       :::|...: .|:|.|   .|:.:.|.|..|::.:||||..|...|...|:
  Rat   510 DPPNTSGN-------VSVAVDPR-RERTNRQAAESAKEYPPLMPTNEMKDSVPEKAVTKKGAGIA 566

Human   559 G-TVSCQKQPALKATSD---------KKDSVSNIPTEIKDGQQSGTVS----------------- 596
            . .:...:.||:|.||:         :::..|||..:|.. |..|.:|
  Rat   567 QLDMDLSEGPAVKLTSEEEPNRQDGFERNPPSNILKQIPT-QDIGYLSIPKYQRGEKMVASKAKE 630

Human   597 -SQKQPAWKATSVKKDSVSN-------IATEIKDGQIRGTVSSQRRPALKTTGDEKDSVSNIARE 653
             |::.|..|.|.||::|||.       :.:.::|       :.:..|..|.|.::.|.|.|...:
  Rat   631 FSKECPQSKPTIVKEESVSKEVWDVIPVKSYLED-------TPKDYPLSKPTVEKSDYVPNEVSD 688

Human   654 IKDGEKSGTVSPQKQSAQKVIFKKKVSLLNIATRITGGGKSGTEYPENLRTLKATIENKDSVLNT 718
            :|.|:               .|::..                   |:....||..||.:||....
  Rat   689 MKHGK---------------WFQENC-------------------PKGCAQLKIPIEERDSFQRE 719

Human   719 ATKMKEVQT---STP--------------AEQDLEMASEGEQKRLEEYENN----------QPQV 756
            |...|:|::   ..|              ||..:::.||.:||||::.|.|          |||.
  Rat   720 APPAKQVKSYCADEPVKSYSRITRCVRQNAESAVKVTSEEDQKRLDDQEKNQQMQAALRRPQPQD 784

Human   757 KNQIHSRDDLDDIIQSSQTVSEDGDSLCCNCKNVILLIDQHEMKCKDCVHLLKIKNTFCLWKRLI 821
            ...:...:|      .|:..||:|..
  Rat   785 IEYLSMAND------ESRENSEEGQE--------------------------------------- 804

Human   822 KLKDNHCEQLRVKIRKLKNKASVLQKRISEKEEIKSQLKHE----ILELEKELCSLR-------- 874
              :|:..:||..|..:...:......::|..:..||.|..|    :.|.|:|.|..|
  Rat   805 --EDSSEQQLPFKSTQPTTEEDSSPNKVSATKPEKSFLTAEPTTNVSEGEQERCGSRNMQRQGVG 867

Human   875 --FAIQQEKKKRRNVEELHQKVRE---KLRITEEQYRIEADVTKPIKPALKSAEVELKTGGNNSN 934
              |..:.:::...:.::..:...|   :|:.|:     ..|..|...|....|:.|:||
  Rat   868 NLFLAEDDERSESSTQDEEEDFPEGYVQLKPTQ-----PLDKEKTPLPREAPAKNEVKT------ 921

Human   935 QVSETDEKEDLLHENRLMQDEIARLRLEKDTIKNQNLEKKYLKDFEIVKRKHEDLQKALKRNGET 999
            .|||:||......|...:.|.                |:::.|:.:.....|..|.|..:|...|
  Rat   922 FVSESDESLSSEEEQEWLADS----------------EEEHRKEAQPKDAAHLSLAKDERRVNAT 970

Human  1000 LAKTIACYSGQLAALTDENTTLRSKLEKQ 1028
                    |.|.....||...|::..|||
  Rat   971 --------SSQEKGSPDEYPELKASTEKQ 991

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ANKRD36B	NP_001380868.1	ANKYR	17..209	CDD:223738	80/192 (42%)
		ANK 1	19..48		7/29 (24%)
		Ank_2	24..116	CDD:403870	42/92 (46%)
		ANK repeat	24..50	CDD:293786	6/26 (23%)
		ANK 2	52..81		14/28 (50%)
		ANK repeat	54..83	CDD:293786	13/28 (46%)
		ANK repeat	85..116	CDD:293786	18/30 (60%)
		ANK 3	85..114		17/28 (61%)
		ANK 4	118..147		14/28 (50%)
		ANK repeat	118..142	CDD:293786	12/23 (52%)
		ANK repeat	151..182	CDD:293786	10/30 (33%)
		ANK 5	151..180		10/28 (36%)
		ANK repeat	184..215	CDD:293786	12/30 (40%)
		ANK 6	184..213		11/28 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	249..307		11/57 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	349..607		70/313 (22%)
		CCDC158	712..>1342	CDD:318193	71/361 (20%)
		CCDC144C	949..1240	CDD:405585	16/80 (20%)
Poteg	XP_038950658.1	ANK repeat	51..78	CDD:293786	6/26 (23%)
		ANKYR	<77..203	CDD:223738	61/125 (49%)
		ANK repeat	82..111	CDD:293786	13/28 (46%)
		ANK repeat	116..144	CDD:293786	18/27 (67%)
		PHA03095	132..>304	CDD:222980	68/177 (38%)
		ANK repeat	146..177	CDD:293786	15/30 (50%)
		ANK repeat	179..210	CDD:293786	10/30 (33%)
		ANK repeat	212..243	CDD:293786	12/30 (40%)
		PTZ00121	<497..917	CDD:173412	103/522 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BCY7
HGNC	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D24863at7742
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820