DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ANKRD36B and mib2

DIOPT Version :9

Sequence 1:NP_001380868.1 Gene:ANKRD36B / 57730 HGNCID:29333 Length:1353 Species:Homo sapiens
Sequence 2:NP_001260554.1 Gene:mib2 / 35170 FlyBaseID:FBgn0086442 Length:1049 Species:Drosophila melanogaster


Alignment Length:568 Identity:113/568 - (19%)
Similarity:191/568 - (33%) Gaps:174/568 - (30%)


- Green bases have known domain annotations that are detailed below.


Human    30 RGNLEKLKYLLLTYYDANKRDRKERTALHLACATGQPEMVHLLVSRRCELNLCDREDRTPLIKAV 94
            :|.::.:.||:....:.|..|::..:|||.|....||..:.:|:....|:|..:....:.|....
  Fly   474 QGYVDLVSYLISKGANVNAVDKEGDSALHYAAFGNQPATMRVLLQHGAEVNFLNSSHCSALHICA 538

Human    95 QLRQEACATLLLQNGADPNITDVFGRTALHYAVYNEDTSMIEKLLSHGTNIEECSKN-------- 151
            ..:...|...|||:.|:.||.|.:|.||||.|:..|:|.::| ||.:..|::...||        
  Fly   539 HKKTPHCVRELLQHNANVNIQDSYGDTALHDAIGKENTEVVE-LLCNAPNLDFTVKNNRGFNVLH 602

Human   152 --------------------------------------------------------------EYQ 154
                                                                          :..
  Fly   603 HAALKGNVVAARRILLLSRQLVNVRKDDGFAALHLAALNGHAQVVETLVTEGQAELDIRNNRQQT 667

Human   155 PLLLAVSRRKVKMVEFLLKKKANVNAIDYLGRSALILAV-------TLGEKD---------IVIL 203
            |.|||||:....::|.|::...:|||.|..|.:|:.|.|       :..|..         ..:.
  Fly   668 PFLLAVSQGHAGVIERLVRLSCDVNAKDEDGDNAMHLCVIKKSNLQSAAEPQPEEAPEIHKFYLS 732

Human   204 LLQHNIDVFSRDVYGKLAEDYASEAENRVIFD----LIYEYKRKRY------------EDLPINS 252
            |:..:|....|.:|..|.  |.|.|..||..:    .|:|:...|:            |.||.|.
  Fly   733 LVHSSIRPEDRLMYSILI--YLSRAGCRVELNNANASIFEWITDRHIRQLIFGQQGEAESLPRNL 795

Human   253 NPVSPQKQRAEKATSDDKDSVSNIATEIKEGPISGTVSSQKQP--------------------AE 297
                 |.......::|.::|.::...| ..|...|:|::...|                    |.
  Fly   796 -----QALEVSAGSADGEESSASAGAE-SNGAGPGSVAAPPPPQRQTFELMPKPNDIPAIGVGAS 854

Human   298 KATSDEKDSVSNIATEIKEGQQSGTVSPQKQSAQKVIFKKKVSLLNIATRIMGGGKSGTVS---- 358
            .:|......|..:.::......|..|:|:|::.     |..|:..:.:|.:..|....:.|    
  Fly   855 PSTPSASPGVKKLNSDATPQNVSPQVAPRKKAP-----KPPVTTSSSSTALEAGAAGPSTSPVIV 914

Human   359 --------------------SQKQPASKTASDKTDSALNTATEIKDGLQCGTVSSQKQQALKATT 403
                                .|.|.|.:....:....|..|..|:..|   |||. :..||..:|
  Fly   915 PGPHECIVCNEILPMVRFEPCQHQIACEECGIRMKKCLRCAVAIERRL---TVSG-RVVALPTST 975

Human   404 DEEGSVSNIATEIKDGEKSGTVSSQKKPALKATSDEKDSFSNITREKK 451
                |..:..|.:..|:....:.:      |....|:..|..|..|:|
  Fly   976 ----SSPSDPTRLPSGDLLRYLEN------KVLEFEESHFCGICMERK 1013

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ANKRD36BNP_001380868.1 ANKYR 17..209 CDD:223738 55/264 (21%)
ANK 1 19..48 3/17 (18%)
Ank_2 24..116 CDD:403870 22/85 (26%)
ANK repeat 24..50 CDD:293786 4/19 (21%)
ANK 2 52..81 8/28 (29%)
ANK repeat 54..83 CDD:293786 9/28 (32%)
ANK repeat 85..116 CDD:293786 8/30 (27%)
ANK 3 85..114 6/28 (21%)
ANK 4 118..147 12/28 (43%)
ANK repeat 118..142 CDD:293786 11/23 (48%)
ANK repeat 151..182 CDD:293786 12/100 (12%)
ANK 5 151..180 10/98 (10%)
ANK repeat 184..215 CDD:293786 7/46 (15%)
ANK 6 184..213 7/44 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 249..307 12/77 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 349..607 24/127 (19%)
CCDC158 712..>1342 CDD:318193
CCDC144C 949..1240 CDD:405585
mib2NP_001260554.1 MIB_HERC2 8..73 CDD:284184
ZZ_Mind_bomb 85..129 CDD:239079
MIB_HERC2 156..220 CDD:284184
ANK 464..582 CDD:238125 32/108 (30%)
ANK repeat 464..494 CDD:293786 4/19 (21%)
Ank_2 468..560 CDD:289560 22/85 (26%)
ANK repeat 496..527 CDD:293786 9/30 (30%)
ANK repeat 529..560 CDD:293786 8/30 (27%)
Ank_5 549..604 CDD:290568 21/55 (38%)
ANK 557..685 CDD:238125 24/128 (19%)
ANK repeat 596..628 CDD:293786 0/31 (0%)
Ank_2 601..695 CDD:289560 11/93 (12%)
ANK repeat 630..662 CDD:293786 0/31 (0%)
ANK repeat 664..695 CDD:293786 11/30 (37%)
zf-C3HC4_3 918..961 CDD:290631 6/42 (14%)
zf-C3HC4_3 1002..1044 CDD:290631 4/12 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.000

Return to query results.
Submit another query.