DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ANKRD36B and Ankrd26

DIOPT Version :9

Sequence 1:	NP_001380868.1	Gene:	ANKRD36B / 57730	HGNCID:	29333	Length:	1353	Species:	Homo sapiens
Sequence 2:	XP_006506085.1	Gene:	Ankrd26 / 232339	MGIID:	1917887	Length:	1686	Species:	Mus musculus

Alignment Length:	1450	Identity:	466/1450 - (32%)
Similarity:	714/1450 - (49%)	Gaps:	284/1450 - (19%)

- Green bases have known domain annotations that are detailed below.

Human     3 RLCSDGFAFPHYYIKPYHLKRIHRAVLRGNLEKLKY-LLLTYYDANKRDRKERTALHLACATGQP 66
            |..:.|...|.|:|....:.:||:|...|::.|::: |:|.....|.||:|:|||||||||.|.|
Mouse    30 RESASGSHVPRYHIHDKDMGKIHKAASVGDVAKVQHILILGKSGVNDRDKKDRTALHLACAYGHP 94

Human    67 EMVHLLVSRRCELNLCDREDRTPLIKAVQLRQEACATLLLQNGADPNITDVFGRTALHYAVYNED 131
            |:|.|||.|:||::..|.|..|.||||||.::|.||.:||.:|||||:.|..|.||||||||:|:
Mouse    95 EVVTLLVERKCEIDARDSESSTALIKAVQCQEEECAAILLDHGADPNVMDSSGNTALHYAVYSEN 159

Human   132 TSMIEKLLSHGTNIEECSKNEYQPLLLAVSRRKVKMVEFLLKKKANVNAIDYLGRSALILAVTLG 196
            |||..|||:|..|||..:|::..|:||||...|..:||||:||||:::|:|.||
Mouse   160 TSMAAKLLAHNANIEAKNKDDLTPMLLAVKENKQHIVEFLVKKKASIHAVDQLG----------- 213

Human   197 EKDIVILLLQHNIDVFSRDVYGKLAEDYASEAENRVIFDLIYEYKRKRYEDLPINSNPVSPQKQR 261
                                            .||.:|:  |:.||.:..:   |||||
Mouse   214 --------------------------------SNRQMFE--YDGKRLQRSE---NSNPV------ 235

Human   262 AEKATSDDKDSVSNIATEIKEGPISGTVSSQKQPAEK-ATSDEKD---SVSNIATEIKEGQQSGT 322
                   |..|.....|.....|         .||:. .||||:|   ...|:
Mouse   236 -------DNGSEDGSLTRSYNTP---------GPADSWPTSDEEDYNFDNKNV------------ 272

Human   323 VSPQKQSAQKVIFKKKVSLLNIATRIMGGGKSGTVSSQKQPASKTASDKTDSALNTATEIKDGLQ 387
                          .|::|..:.|......|:.|....::..:....|.:||    .:|.:|.::
Mouse   273 --------------PKINLTELWTAAQQSRKNQTKCGFEELDNGARFDDSDS----PSESEDAIE 319

Human   388 CGTVSSQKQQALKATTDEEGSVSNIATEIK-DGEKSGTVSSQKKPALKATSDEKDSFSNITREKK 451
            .....|.:.|.|..:......|.. |||:. :||::||      ..:::.|.|:.:..|:||  .
Mouse   320 VEPAPSVRVQTLSPSRQSPDPVEG-ATELAIEGEENGT------DVIESASQEQPNHDNLTR--A 375

Human   452 DGEISRTVSSQKPPALKATSVKEDSVLNIAREKKDGEKSRTVSFEQPPGLKATRDEKDSLLNIAR 516
            ||    ...|.|...:.|..:.||         :|         |..|....:..|..||.::..
Mouse   376 DG----WHKSNKSEMMSALGLGED---------ED---------EHSPWDSESISESVSLKDVGH 418

Human   517 GKKDGEKTRRVSSHKQPSLKATSDKEDSVPNMATETKDEQISGTVSCQKQPALKATSDKKDSVSN 581
            .....::|.:..:|.|                     .|.::...||.       :..:...::.
Mouse   419 FSGTADQTGKRRAHGQ---------------------IEDVTYIPSCM-------SGSRSFKMAK 455

Human   582 IPTEIKDGQQSGTVSSQKQPAWKATSVKKDSVSNIATEIKDGQIRGTVSSQRRPALKTTGDEKDS 646
            :......|.....:..:|..|.:..::.:.::...|..:...:..|...:|      |...|.:|
Mouse   456 LEESRNVGLPVAHMGMEKNEAPRKYAIMEPTIERRAPVLNKTETVGMTDAQ------TFKSEPES 514

Human   647 VSNIAREIKDGEKSGTVSPQKQSAQKVIFKKKVS------LLNIATRITGGG-----KSGTEYPE 700
            ||.        |:...:|..:.|.|||..|:|..      ..|:.:....||     :||.  .|
Mouse   515 VSR--------EEQTRLSGSEDSQQKVEEKRKYKNNEAEPSGNLYSGAADGGADVKPQSGD--TE 569

Human   701 NLRTLKATIENKDS----VLNTATKMKE--------VQTST-----------PAEQDLEMASEGE 742
            |.::.:...|.:.|    ::..|.||:.        .:|:.           |..||....|:.:
Mouse   570 NQQSPREGSEGRGSGPALLMKEAKKMENEKWVSREPARTAMSERTGLPTGGWPQMQDGSCWSDTD 634

Human   743 Q------KRLEEYENNQPQVKNQIHSRDDLDDIIQSSQTVSEDGDSLCCNCKNVILLIDQHEMKC 801
            |      |:.....|..   ..|..:.|:|||..:||:|.|||.:....:.::::..|:...::|
Mouse   635 QSEARPTKKTSSKHNKD---SGQTAAVDNLDDFTESSETASEDHELQGPDSESILCAIEHLRLEC 696

Human   802 KDCVHLLKIKNTFCLWKRLIKLKDNHCEQLRVKIRKLKNKASVLQKRISEKEEIKSQLKHEILEL 866
            ||...||||::....:||||:||.:|||.|..|:::::||...|||.:||.||:||:|:||.:..
Mouse   697 KDTASLLKIRDAVYSYKRLIELKRSHCELLTGKLKRMENKYKGLQKEMSETEEVKSRLEHEKVGW 761

Human   867 EKELCSLRFAIQQEKKKRRNVEELHQKVREKLRITEEQYRIEADVTKPIKPALKSAEVELKTGGN 931
            |:|||.||||::||::|||:.::|.:|..|:||...||.:.|.:..:.::.:|::.|:||||..:
Mouse   762 EQELCRLRFALKQEEEKRRSADQLSEKTSEQLRRKGEQCQSEVEARQQLEASLRTLEMELKTVKS 826

Human   932 NSNQVSE----------------------------------------------TDEKE-DLLHEN 949
            :.|||.|                                              :.||| ||||:|
Mouse   827 HLNQVLEERNETQRQLSREQNARMLQDGILASHLCKQKEIEMTQKKMTSEVSVSHEKEKDLLHKN 891

Human   950 RLMQDEIARLRLEKDTIK--NQNLEKKYLKDFEIVKRKHEDLQKALKRNGETLAKTIACYSGQLA 1012
            :.:|||:|.||||.||||  ||..||:||:|.:|...|:::||:.:|.|.||..|||..|:|||.
Mouse   892 QRLQDEVAVLRLEMDTIKSHNQEKEKRYLEDIKIANEKNDNLQRMVKLNEETFTKTIFQYTGQLN 956

Human  1013 ALTDENTTLRSKLEKQRESRQRLETEMQSYRCRLNAARCDHDQSHSSKRDQELAFQ-------GT 1070
            :|..|||.|.|||:.::::::||||:::|:|.||.:|..||.:..::|||.|:|||       ..
Mouse   957 SLKAENTMLSSKLDNEKQNKERLETDVESFRSRLASALHDHAEIQTAKRDLEIAFQRARDEWFRV 1021

Human  1071 VDKCRHLQENLNSHVLILSLQLSKAESKSRVLKTELHYTGEALKEKALVFEHVQSELKQKQSQMK 1135
            .||......||..:..:||.||||.|.|...|:.|.|:|.:.|:||.|..:|.|.:|.|.|.|||
Mouse  1022 KDKMNFDMSNLRDNNEVLSQQLSKTERKLNSLEIEFHHTKDELREKTLALKHAQRDLSQTQCQMK 1086

Human  1136 DIEKMYKSGYNTMEKCIEKQ----ERFCQLKKQNMLLQQQLDDARNKADNQEKAILNIQARCDAR 1196
            ::|.|::.....:.|.:.||    ||..||:.:|.||:||||||.|||::::|.|:|||.:....
Mouse  1087 EVEHMFQDEQGKVSKFMGKQESIEERLAQLQSENTLLRQQLDDAANKAESKDKTIVNIQDQFQDV 1151

Human  1197 VQNLQAECRKHRLLLEEDNKMLVNELNHSKEKECQYEKEKAEREVAVRQLQQKRDDVLNKGSATK 1261
            :...|||.::|.|.||:.|:.||:|.:|.:|:.||||.|||||||.||||||:..|.|.|.|.::
Mouse  1152 LTRFQAESQRHSLRLEDRNQELVSECSHLRERLCQYENEKAEREVVVRQLQQELADTLKKQSMSE 1216

Human  1262 ALLDASSRHCTYLENGMQDSRKKLDQMRSQFQEIQDQLTATIRCTKEMEGDTQKLEVEHVMMRKI 1326
            |.|:.|||:.:.||...:|.:|||.|:|||.||.:||....:...::||...||||:|.......
Mouse  1217 ASLEVSSRYRSNLEEEARDLKKKLGQLRSQLQEARDQHREAVHHAEKMEDHLQKLELEKSKFEIT 1281

Human  1327 IKKQDDQIERLEKILQHSSL 1346
            ||||.::|::|::.|...:|
Mouse  1282 IKKQSEEIDQLQENLSRVNL 1301

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ANKRD36B	NP_001380868.1	ANKYR	17..209	CDD:223738	89/192 (46%)
		ANK 1	19..48		7/29 (24%)
		Ank_2	24..116	CDD:403870	49/92 (53%)
		ANK repeat	24..50	CDD:293786	8/26 (31%)
		ANK 2	52..81		20/28 (71%)
		ANK repeat	54..83	CDD:293786	19/28 (68%)
		ANK repeat	85..116	CDD:293786	18/30 (60%)
		ANK 3	85..114		17/28 (61%)
		ANK 4	118..147		19/28 (68%)
		ANK repeat	118..142	CDD:293786	16/23 (70%)
		ANK repeat	151..182	CDD:293786	15/30 (50%)
		ANK 5	151..180		14/28 (50%)
		ANK repeat	184..215	CDD:293786	2/30 (7%)
		ANK 6	184..213		2/28 (7%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	249..307		16/61 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	349..607		45/258 (17%)
		CCDC158	712..>1342	CDD:318193	275/718 (38%)
		CCDC144C	949..1240	CDD:405585	136/303 (45%)
Ankrd26	XP_006506085.1	ANK repeat	51..78	CDD:293786	8/26 (31%)
		PLN03192	<54..277	CDD:215625	111/318 (35%)
		ANK repeat	82..111	CDD:293786	19/28 (68%)
		Ank_2	85..177	CDD:372319	56/91 (62%)
		ANK repeat	113..144	CDD:293786	18/30 (60%)
		ANK repeat	146..177	CDD:293786	20/30 (67%)
		ANK repeat	179..210	CDD:293786	15/30 (50%)
		Smc	728..1559	CDD:224117	235/573 (41%)
		CCDC144C	891..1194	CDD:373382	135/302 (45%)
		DUF3496	1500..1607	CDD:371843
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
HGNC	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D157201at33208
OrthoFinder	1	1.000	-	-		FOG0004868
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920