Protein Alignment PTPN2 and ptpn2b

DIOPT Version :10

• Sequence 1: XP_047293651.1
• Gene: PTPN2 / 5771
• HGNCID: 9650
• Length: 494
• Species: Homo sapiens
• Sequence 2: NP_997819.1
• Gene: ptpn2b / 561613
• ZFINID: ZDB-GENE-030909-8
• Length: 393
• Species: Danio rerio
• Alignment Length: 397
• Identity: 240/397 - (60%)
• Similarity: 301/397 - (75%)
• Gaps: 36/397 - (9%)

Human   108 EIRNESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVKLQNAENDYINASLVDIEEAQRSYILTQG 172
            ||||:||:...:|||:||||.|||||||||:|||||||:|.||||||||||.:|||||.||||||
Zfish    20 EIRNQSHECAFKVAKYPENRIRNRYRDVSPFDHSRVKLENTENDYINASLVVMEEAQRRYILTQG 84

Human   173 PLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPT-DDQEMLFKETGFSVKLLSEDVKS 236
            ||.|||.|||||:|:||||||:||||::||.|.|||||||| :::||.|::|.|.|.|:||||||
Zfish    85 PLRNTCGHFWLMIWEQKTKAVIMLNRVIEKGSEKCAQYWPTQEEREMSFRDTRFVVTLVSEDVKS 149

Human   237 YYTVHLLQLENINYIENLWITLYLKLLMLDVKRSLKSGETRTISHFHYTTWPDFGVPESPASFLN 301
            |||..:|:|:|.|                       :||||.|.|||||||||||||||||||||
Zfish   150 YYTTRVLELQNAN-----------------------TGETREIYHFHYTTWPDFGVPESPASFLN 191

Human   302 FLFKVRESGSLNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDD---INIKQVLLNMRKYRM 363
            |||||||||||..:.||||:||||||||||||||||||||||:|..|   ::||::||:||||||
Zfish   192 FLFKVRESGSLGMEQGPAVVHCSAGIGRSGTFSLVDTCLVLMDKRKDPLLVDIKKILLDMRKYRM 256

Human   364 GLIQTPDQLRFSYMAIIEGAKCIKGDSSIQKRWKELSKEDLSPAFDHSP---NKIMTEKYNGNR- 424
            |||||||||||||||::||||.|.||||:||:|:|||:||..|..:..|   ....||:|||::
Zfish   257 GLIQTPDQLRFSYMAVLEGAKYIMGDSSVQKQWRELSREDQEPLSESPPPPQPPKCTERYNGSKP 321

Human   425 IGLEE--EKLTGDRCTGLSSKMQDTMEENSESALRKRIREDRKATTAQKVQ-QMKQRLNENERKR 486
            ..||:  :..||.: ||..:..::. :.::.:..|||:|:::.:..:||.| |.|.|:|:.::||
Zfish   322 AHLEDGIDSKTGKK-TGPEAPNKEP-DRDAGTQARKRLRDEKMSNPSQKTQKQTKPRINDPDKKR 384

Human   487 KRPRLTD 493
            ||.|.|:
Zfish   385 KRARTTN 391

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PTPN2	XP_047293651.1	PTP_DSP_cys	108..379	CDD:475123	192/274 (70%)
ptpn2b	NP_997819.1	PTP_DSP_cys	15..272	CDD:475123	192/274 (70%)