Protein Alignment PTPN2 and PTP-ER

DIOPT Version :9

• Sequence 1: XP_005258181.1
• Gene: PTPN2 / 5771
• HGNCID: 9650
• Length: 438
• Species: Homo sapiens
• Sequence 2: NP_726092.1
• Gene: PTP-ER / 37461
• FlyBaseID: FBgn0016641
• Length: 1377
• Species: Drosophila melanogaster
• Alignment Length: 498
• Identity: 98/498 - (19%)
• Similarity: 161/498 - (32%)
• Gaps: 209/498 - (41%)

Human     3 TTIER------EFEELDTQRRWQPLYLEIRNESHDYPHRVAKFP---ENRNRNRYRDVSPYDHSR 58
            |.:.|      |.:|.:.:|    ::.::..|..|.|....:.|   .::.:|||:.:.|.::||
  Fly   871 TVVSRMAQPIPELKENEQKR----IFRDLHKEFWDLPLNHQEKPMVFGSQTKNRYKTILPNENSR 931

Human    59 VKLQNAEND---------------------YINASLV-DIEEAQRSYILTQGPLPNTCCHFWLMV 101
            |.|::..::                     ||||:.: ..:...:.|:.||||||||...||||:
  Fly   932 VLLESESSELTSLLGEIKRTSSVTASEDLPYINANYIKGPDYVSKCYVATQGPLPNTIFEFWLMI 996

Human   102 W---------------------------QQKTKAVVMLNRIVEKESVKCAQYWPTDDQEMLFKET 139
            :                           ||..:.:|||....|....|||.|:|.:..|:.....
  Fly   997 YQNTQRYIRRCVDGGSSSSPHVDREQILQQYFQKIVMLTNFTEANRQKCAVYFPIELNEIFAVAA 1061

Human   140 GFSVKLLSEDVKSYYTVHL----------LQLENINY--------IENLWITL------------ 174
            ...|..||...:.|:..:|          ...:.|:|        :|::.:||
  Fly  1062 KCEVFQLSAAARDYFDRYLTPTFVPDTVVASSDAIDYEISGRHIGVESVKVTLEGDLLEALPAQG 1126

Human   175 --YL---------------KLLMLDVKRSLKSGETRT----ISHFHYTTWPDFGVPESPASFLNF 218
              :|               ||::|...|..:|.....    ..|:.|..|||...|....:.|:.
  Fly  1127 SFFLIKNVGIVRRNGYSVRKLVLLYCIRVPQSASYHLQKIYCYHYWYPDWPDHHSPRDINTLLDT 1191

Human   219 LFKVRESGSLNPD-------------HGPA------------------VIHCSAGIGRSGTFSLV 252
            ...|...|....:             |..|                  ||||||||||:|.|:.:
  Fly  1192 CLHVLNLGKCESEFDIYDDTRSERNAHLAAQRLEIYQQDIFNAVQPLPVIHCSAGIGRTGCFTAI 1256

Human   253 ----------------------------------------DTCLVL------------------- 258
                                                    .||..:
  Fly  1257 LNAVRQLRQSLAYSLTGMLTKSLTSSSTEEYHNPTDSDSSFTCNTIRHISHILDHRDAEAVKTPP 1321

Human   259 ----MEKGDDI--NIKQVLLNMRKYRMGLIQTPDQLRFSYMAI 295
                :.|..||  ::..::.|:|..|.|::|..:|....:.||
  Fly  1322 SFDRLPKMPDIFVDVLGIVCNLRLQRGGMVQNSEQYELIHRAI 1364

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PTPN2	XP_005258181.1	PTP_DSP_cys	19..295	CDD:391942	91/474 (19%)
PTP-ER	NP_726092.1	Y_phosphatase	916..1364	CDD:278528	87/447 (19%)
		PTPc	917..1364	CDD:238006	87/446 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900