Protein Alignment DENND1A and CG18659

DIOPT Version :10

• Sequence 1: XP_047279569.1
• Gene: DENND1A / 57706
• HGNCID: 29324
• Length: 1088
• Species: Homo sapiens
• Sequence 2: NP_665880.2
• Gene: CG18659 / 35929
• FlyBaseID: FBgn0027561
• Length: 908
• Species: Drosophila melanogaster
• Alignment Length: 1013
• Identity: 277/1013 - (27%)
• Similarity: 385/1013 - (38%)
• Gaps: 318/1013 - (31%)

Human    51 VQRQFPEDYSDQEVLQTLTKFCFPFYVDSLTVSQVGQNFTFVLTDIDSKQRFGFCRLSSGAKSCF 115
            :...|||.:.|||||..:..|.||....|.:|    |.::||.|..|||.||||||......:..
  Fly    43 IVESFPEGFRDQEVLTGIPSFAFPCDTTSTSV----QTYSFVHTTGDSKWRFGFCRQDPRTNTAM 103

Human   116 CILSYLPWFEVFYKLLNILADYTTKRQENQWNELLETLHKLPIPDPG--VSVHLSV-HSYFTV-- 175
            .:::||||.:.|.|||.:||: ..:...|.:...|...:...|||.|  :.|:.|. .|:||.
  Fly   104 VLITYLPWHDTFLKLLPVLAE-LRRTDPNGFRTFLSEAYNQGIPDCGGSLKVYYSAGQSHFTFER 167

Human   176 PDTRELPSIPENRNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMY 240
            |...:|||:|||.||..|:..|:...|:.::|:||.||||:.....|..|::||..:.|.||||.
  Fly   168 PLQFQLPSMPENHNLNLYYNFVEPKEMIAVFAAMLAERRIIFTSRHLDRLSSCIQAANAFLYPMV 232

Human   241 WQHVYIPVLPPHLLDYCCAPMPYLIGIHLSLMEKVRNMALDDVVILNVDTNTLETPFDDLQSLPN 305
            |||::|||||....||..||||||||:...::|.|.:..|.:|||||.||...|:||||:.:||.
  Fly   233 WQHIFIPVLPWEFKDYLGAPMPYLIGVPEPVLETVTSDELGEVVILNCDTKIFESPFDDVHNLPT 297

Human   306 DVISSLKNRLKKVSTTTGDGVARAFLKAQAAFFGSYRNALKIEPEEPITFCEEAFVSHYRSGAMR 370
            :::|.||..|.......||.:::.||.|.....|.||:|::.. |...||..:.|:.. |...:|
  Fly   298 EIVSQLKKHLNHTHDHIGDRISKIFLNALVQLIGGYRDAVEYH-ENSKTFNSQKFIES-RPAHLR 360

Human   371 QFLQNATQLQLFKQFIDGRLDLLNSGEGFSDVFEEEINMGEYAGSDKLYHQWLSTVRKGSGAILN 435
            .||.....||:|.||||.||.:||||.||||.|  |:....||...|         |..:.||:.
  Fly   361 PFLAKMMDLQIFAQFIDDRLTMLNSGLGFSDEF--ELETVRYAEKKK---------RGRNYAIMK 414

Human   436 TVKTKANPAMKTVYKFAKDHAKMGIKEVKNRLKQKDIAENGCAPTPEEQLPKTAPSPLVEAKDPK 500
            .:|.|.|||:|:..|..|:.:: |:|......|.| :.|||      .|...|
  Fly   415 NLKDKTNPAVKSAVKSVKEGSR-GMKTAYKGFKTK-LRENG------NQFGGT------------ 459

Human   501 LREDRRPITVHFGQLQRLRPTRPPPKIQRSRPVRPPRPHVVKRPKSNIAVEGRRTSVPSPEHLVK 565
                    ..|||                                           :.||.|
  Fly   460 --------HFHFG-------------------------------------------LGSPNH--- 470

Human   566 PLRHYAVFLSEDSSDDECQREEGPSSGFTE------SFFFSAPFEWPQPYRTLR--------ESD 616
                         ||    |.:|.|.|:..      :...|||   ..|..:.|        .|.
  Fly   471 -------------SD----RPDGTSGGYVRGGKAIGAAHHSAP---SSPVTSKRLDGIASVTGSS 515

Human   617 SAEGDEAESPEQQVRKSTGPVPAPPDRAASIDLLEDVFSNLDMEAALQPLGQAK----------- 670
            .:.|..|..|.:.:|:  ||||.....::|               .:||.|.|.
  Fly   516 GSGGSGAREPREFLRR--GPVPLAMSSSSS---------------HIQPNGHAYGASAGAHYGHH 563

Human   671 --------------SLEDLRAPKDLREQPGTFDYQRLDLG---GSERSRGV-----------TVA 707
                          |..::...::|:..| .|....:|..   .:|..||.           |.|
  Fly   564 LAASPAVSSASSLCSSSEMNLSQELQNHP-LFKTPAVDRSLKPNAEHRRGAAPPARPPPPQSTPA 627

Human   708 LKLTHPYNKLWSLGQDDMAIP---SKPPAASPEKPSALLGNSLALPRRPQNRDSILNPSDKEEVP 769
            ....|||          .|.|   ||||            ...:.|.||:.             |
  Fly   628 SYYNHPY----------AAHPHVESKPP------------RHTSTPTRPRQ-------------P 657

Human   770 TPTLGSITIPRPQGRKTPELGIVPPPPIP------RPAKLQAAGAALGDVSERLQTD-------- 820
            .||..|.:...|     |:   |..||||      ..|.:.|..||:.....:|:.:
  Fly   658 LPTADSSSFDSP-----PD---VQSPPIPPRRQGSSNAIVAATAAAVSAEISKLERNCWKDEPGN 714

Human   821 ---RDRRAALSPGLL----------------------PGVVPQGPTELLQPLSPGPGAAGTSSDA 860
               |...|:.|....                      |...|:...|..|||.       .|.:.
  Fly   715 DSVRSSNASSSSATSSSSGASFVTAASTFSHLNVSDPPIPTPRAKREQQQPLE-------DSMND 772

Human   861 LLAL----------------------LDPLSTAWSG--STLP----SRPATPNVATPFTPQFSFP 897
            |::|                      |.|||||::.  ||||    |.....:|:.|..|.|:..
  Fly   773 LISLDDSNNTSFDLEDFDPLNQNARPLPPLSTAFAKKCSTLPAGVNSSVVASSVSNPLYPYFAPK 837

Human   898 PAGTPTPFP--QPPLNPFVPSMPAAPPTLPLVSTPAGP 933
            ...|.....  .||::|        ||.:...:..|.|
  Fly   838 HMATVAAVTGRTPPMHP--------PPQIQRNTIAAKP 867

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DENND1A	XP_047279569.1	uDENN	<48..109	CDD:214824	26/57 (46%)
		DENN	113..291	CDD:214823	76/182 (42%)
		dDENN	323..389	CDD:129037	24/65 (37%)
		PHA03247	<723..1074	CDD:223021	60/283 (21%)
CG18659	NP_665880.2	uDENN	10..95	CDD:214824	25/55 (45%)
		DENN	98..282	CDD:460461	75/184 (41%)
		dDENN	315..379	CDD:129037	24/65 (37%)