DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment WDFY4 and Wdfy4

DIOPT Version :9

Sequence 1:	XP_011538288.2	Gene:	WDFY4 / 57705	HGNCID:	29323	Length:	3224	Species:	Homo sapiens
Sequence 2:	XP_006519340.1	Gene:	Wdfy4 / 545030	MGIID:	3584510	Length:	3183	Species:	Mus musculus

Alignment Length:	3191	Identity:	2588/3191 - (81%)
Similarity:	2806/3191 - (87%)	Gaps:	15/3191 - (0%)

- Green bases have known domain annotations that are detailed below.

Human    41 MEAEDLSKAEDRNEDPGSKNEGQLAAVQPDVPHGGQSSSPTALWDMLERKFLEYQQLTHKSPIER 105
            ||||||||.|||.||||.:||||..||:|.....|||..|:.||||||:|||:||||..::|.||
Mouse     1 MEAEDLSKTEDRPEDPGFQNEGQSPAVKPSFSLEGQSPGPSVLWDMLEQKFLDYQQLMPRNPEER 65

Human   106 QKSLLSLLPLFLKAWEHSVGIICFPSLQRLAEDVSDQLAQQLQKALVGKPAEQARLAAGQLLWWK 170
            :|:|||||||||||||||||||||.|||||||||||||||::|:||.||||||||.||||||.||
Mouse    66 RKNLLSLLPLFLKAWEHSVGIICFRSLQRLAEDVSDQLAQEIQQALAGKPAEQARAAAGQLLQWK 130

Human   171 GDVDQDGYLLLKSVYVLTGTDSETLGRVAESGLPALLLQCLYLFFVFPLDKDELLESDLQVQKMF 235
            .|.||||.||||||||||||||||||||.:|||||||||||||||.||::||:|||||:|.|:||
Mouse   131 SDADQDGNLLLKSVYVLTGTDSETLGRVVDSGLPALLLQCLYLFFAFPVEKDDLLESDVQGQRMF 195

Human   236 VQMLLNICSDSQGLEGLLSGSELQSLLIATTCLREHSCCFWKEPTFCVLRAISKAQNLSIIQYLQ 300
            |||||||||:||||||||||||||||||||||||||||.|||:|||||||||||||:.|:||||:
Mouse   196 VQMLLNICSESQGLEGLLSGSELQSLLIATTCLREHSCLFWKQPTFCVLRAISKAQSPSVIQYLR 260

Human   301 ATDCVRLSLQNLSRLTDTLPAPEVSEAVSLILGFVKDSYPVSSALFLEFENSEGYPLLLKVLLRY 365
            ..||||||:||||:|.||||||||||||||||.||:||||:||||.|||||.|||||||||||||
Mouse   261 TADCVRLSVQNLSKLADTLPAPEVSEAVSLILNFVRDSYPISSALLLEFENGEGYPLLLKVLLRY 325

Human   366 DGLTQSEVDPHLEELLGLVVWLTTCGRSELKVFDSITYPQLEGFKFHHEASGVTVKNLQAFQVLQ 430
            :||||..|:||||||:.||:|||||||||||||||:|||||||||||.|||||||||||||||||
Mouse   326 NGLTQGVVEPHLEELIELVMWLTTCGRSELKVFDSVTYPQLEGFKFHQEASGVTVKNLQAFQVLQ 390

Human   431 NVFHKASDSVLCIQVLSVIRTMWAWNARNFFLLEWTLQPISQFVEIMPLKPAPVQEHFFQLLEAL 495
            |:||:|||||||||||..|:||||||.||||||||||||||||.||:||||.|||||||||||.|
Mouse   391 NLFHRASDSVLCIQVLLAIKTMWAWNPRNFFLLEWTLQPISQFAEIIPLKPTPVQEHFFQLLETL 455

Human   496 VFELHYVPHEILRKVQHLIKESPGPSCTLMALQSILSIAGGDPLFTDIFRDSGLLGLLLAQLRKQ 560
            ||:|.|||||:|.|||.|||||...||||:||:|||.|...|.||||||||||||||||||||||
Mouse   456 VFKLLYVPHEVLAKVQRLIKESSELSCTLVALRSILRITASDRLFTDIFRDSGLLGLLLAQLRKQ 520

Human   561 AKIMRKSGNKVSTPGVQDPERELTCVMLRIVVTLLKGSVRNAVVLKDHGMVPFIKIFLDDECYRE 625
            ||||||||||..:|.|||||||||.|||..|||||:||||||||||||||||||||||||||||.
Mouse   521 AKIMRKSGNKECSPDVQDPERELTYVMLSTVVTLLQGSVRNAVVLKDHGMVPFIKIFLDDECYRG 585

Human   626 ASLSILEQLSAINAEEYMSIIVGALCSSTQGELQLKLDLLKSLLRILVTPKGRAAFRVSSGFNGL 690
            .|||||||||.||||||||||||||||||||||||||||||||||||.||||.||||||||||||
Mouse   586 PSLSILEQLSVINAEEYMSIIVGALCSSTQGELQLKLDLLKSLLRILETPKGHAAFRVSSGFNGL 650

Human   691 LSLLSDLEGSLQEPPLQAWGAVSPRQTLELVLYTLCAVSAALHWDPVNGYFFRRNGLFEKLAEDL 755
            ||||||||||||.|.:...|||||.|||||||:|||.||||||.||||.:|||.|||||||||||
Mouse   651 LSLLSDLEGSLQVPEVTTCGAVSPSQTLELVLHTLCVVSAALHLDPVNEHFFRSNGLFEKLAEDL 715

Human   756 CLLGCFGALEEEGNLLRSWVDTKARPFADLLGTAFSSSGSLPPRIQSCLQILGFLDSMASGTLHL 820
            |||||||..|||.....|..|.|||||.|||..|||||...|||:|||||||.||:|||||||||
Mouse   716 CLLGCFGTPEEERTRWDSSSDMKARPFMDLLSCAFSSSCQFPPRLQSCLQILSFLESMASGTLHL 780

Human   821 RGDLKESLRTKQGPVVDVQKGETGSDPQRNFKQWPDLEERMDEGDAAIMHPGVVCIMVRLLPRLY 885
            ||||.|..|..|.|.||.||.|.|. .|..||||||:|:||||||..|||||::|||||||||||
Mouse   781 RGDLMEPARAGQEPSVDAQKAEAGG-RQGKFKQWPDMEDRMDEGDVMIMHPGIICIMVRLLPRLY 844

Human   886 HEDHPQLSEEIQCSLASHIQSLVKSEKNRQVMCEAGLLGTLMASCHRALVTSGSPLHSRLIRIFE 950
            .|||||||||||||:|.|:.||||||||||||||||:|.|||..|.|.|.|.||.|||.||||||
Mouse   845 LEDHPQLSEEIQCSVARHLLSLVKSEKNRQVMCEAGMLRTLMTFCPRTLSTGGSDLHSILIRIFE 909

Human   951 KLASQAIEPDVLRQFLGLGIPSSLSATTKILDSSHTHRGNPGCSGSQTAQGLAEGPWPAAPDAGL 1015
            ||.|||||||||||||||||....||..|.|.....|..|||||||..|  .||.|..::|
Mouse   910 KLGSQAIEPDVLRQFLGLGIRPPRSAAVKSLHLPPGHEDNPGCSGSCAA--TAEKPTDSSP---- 968

Human  1016 HPGVTQAPQPLGESQDSTTALQTALSLISMTSPRNLQPQRAALAPSFVEFDMSVEGYGCLFIPTL 1080
            .||.:||.:|...||.|.|||||.|||||||||||||||||||.|||||||||.|||||||.|||
Mouse   969 RPGGSQALRPSWASQYSATALQTTLSLISMTSPRNLQPQRAALTPSFVEFDMSSEGYGCLFTPTL 1033

Human  1081 STVMGTSTEYSVSGGIGTGATRPFPPPGGLTFSCWFLISRHGAATEGHPLRFLTLVRHLARTEQP 1145
            |||||||||:|:|||.|:||.|||||||||||||||||||.....||||||||||||||||||||
Mouse  1034 STVMGTSTEHSISGGTGSGAPRPFPPPGGLTFSCWFLISRQANVMEGHPLRFLTLVRHLARTEQP 1098

Human  1146 FVCFSVSLCPDDLSLVVSTEEKEFQPLDVMEPEDDSEPSAGCQLQVRCGQLLACGQWHHLAVVVT 1210
            |||||:|||.||||||||||||||||||.|||||::|||||.||||||.|||.||||:||||||:
Mouse  1099 FVCFSISLCMDDLSLVVSTEEKEFQPLDAMEPEDEAEPSAGRQLQVRCSQLLTCGQWYHLAVVVS 1163

Human  1211 KEMKRHCTVSTCLDGQVIGSAKMLYIQALPGPFLSMDPSAFVDVYGYIATPRVWKQKSSLIWRLG 1275
            |||||:|:|:|.||||.||||||||||||||.|.|||||:||||||||.|||||||||||.||||
Mouse  1164 KEMKRNCSVTTYLDGQAIGSAKMLYIQALPGSFFSMDPSSFVDVYGYIGTPRVWKQKSSLTWRLG 1228

Human  1276 PTYLFEEAISMETLEVINKLGPRYCGNFQAVHVQGEDLDSEATPFVAEERVSFGLHIASSSITSV 1340
            |.|||||.||.:||.:|.||||||||||||||:||||.|.||||.:|||||||||::.||||||:
Mouse  1229 PAYLFEEDISADTLALIIKLGPRYCGNFQAVHLQGEDPDGEATPLIAEERVSFGLYVPSSSITSI 1293

Human  1341 ADIRNAYNEVDSRLIAKEMNISSRDNAMPVFLLRNCAGHLSGSLRTIGAVAVGQLGVRVFHSSPA 1405
            .:|||.|||||||||||||||||||||.||||||||||||||.|||:||||||||||||||||||
Mouse  1294 MNIRNTYNEVDSRLIAKEMNISSRDNATPVFLLRNCAGHLSGPLRTLGAVAVGQLGVRVFHSSPA 1358

Human  1406 ASSLDFIGGPAILLGLISLATDDHTMYAAVKVLHSVLTSNAMCDFLMQHICGYQIMAFLLRKKAS 1470
            |||||:|||||||||||||||||||||||:||||||||||||||:||||||||||:|||||||.|
Mouse  1359 ASSLDYIGGPAILLGLISLATDDHTMYAAMKVLHSVLTSNAMCDYLMQHICGYQILAFLLRKKTS 1423

Human  1471 LLNHRIFQLILSVAGTVELGFRSSAITNTGVFQHILCNFELWMNTADNLELSLFSHLLEILQSPR 1535
            .|||||||||||||||.|||||.||:||..:|||:|||||||.||||||||:|||||||||||||
Mouse  1424 FLNHRIFQLILSVAGTAELGFRPSAVTNMCIFQHVLCNFELWTNTADNLELTLFSHLLEILQSPR 1488

Human  1536 EGPRNAEAAHQAQLIPKLIFLFNEPSLIPSKISTIIGILACQLRGHFSTQDLLRIGLFVVYTLKP 1600
            |||||||.||||||:|||:||||||||..||:||||.||.|||:|||:.|||||:||||:|||||
Mouse  1489 EGPRNAEVAHQAQLLPKLLFLFNEPSLALSKVSTIIAILGCQLKGHFNIQDLLRVGLFVIYTLKP 1553

Human  1601 SSVNERQICMDGALDPSLPAGSQTSGKTIWLRNQLLEMLLSVISSPQLHLSSESKEEMFLKLGPD 1665
            |||||||||:|||.|||.|||||||||.|||||||||||..||||.||||:||.||::||.||||
Mouse  1554 SSVNERQICLDGAQDPSRPAGSQTSGKAIWLRNQLLEMLFGVISSSQLHLTSELKEQVFLSLGPD 1618

Human  1666 WFLLLLQGHLHASTTVLALKLLLYFLASPSLRTRFRDGLCAGSWVERSTEGVDIVMDNLKSQSPL 1730
            |||||||||||.|||.||||||||||:||.||.||||||.||.|||...:|||||||||||:..:
Mouse  1619 WFLLLLQGHLHPSTTTLALKLLLYFLSSPPLRGRFRDGLSAGCWVENCMDGVDIVMDNLKSRPAV 1683

Human  1731 PEQSPCLLPGFRVLNDFLAHHVHIPEVYLIVSTFFLQTPLTELMDGPKDSLDAMLQWLLQRHHQE 1795
            |:|||||||||||||||||:||.|||||||||:||||||||||.:||:::||.|||||||:|||:
Mouse  1684 PDQSPCLLPGFRVLNDFLAYHVLIPEVYLIVSSFFLQTPLTELTNGPRENLDLMLQWLLQKHHQQ 1748

Human  1796 EVLQAGLCTEGALLLLEMLKATMSQPLAGSEDGAWAQTFPASVLQFLSLVHRTYPQDPAWRAPEF 1860
            ||||||||.|||||||.||||.|:||.|||.||||.||.|:||||||.||||:||||.|||.|:|
Mouse  1749 EVLQAGLCIEGALLLLGMLKAIMNQPPAGSGDGAWEQTLPSSVLQFLRLVHRSYPQDSAWRTPDF 1813

Human  1861 LQTLAIAAFPLGAQKGVGAESTRNTSSPEAAAEGDSTVEGLQAPTKAHPARRKLREFTQLLLREL 1925
            |||:||..|||..||...:||:||||||.|:||.....||.||..:.|||.|:||||.|:|||||
Mouse  1814 LQTVAIITFPLETQKETTSESSRNTSSPGASAEASHAAEGFQASFQPHPALRQLREFMQVLLREL 1878

Human  1926 LLGASSPKQWLPLEVLLEASPDHATSQQKRDFQSEVLLSAMELFHMTSGGDAAMFRDGKEPQPSA 1990
            |||.|:|||||||||:||||||.||||||||||:|||||.|::|.:.||......|..|||.|:|
Mouse  1879 LLGGSNPKQWLPLEVILEASPDGATSQQKRDFQTEVLLSTMDIFQVPSGDGMPTLRGSKEPLPNA 1943

Human  1991 EAAAAPSLANISCFTQKLVEKLYSGMFSADPRHILLFILEHIMVVIETASSQRDTVLSTLYSSLN 2055
            ||.|.||||::|.||||||||:|||:||||||||||||.|||:.|||..|||:|||:|.||||||
Mouse  1944 EAGAVPSLASVSYFTQKLVEKIYSGVFSADPRHILLFITEHIIAVIENPSSQKDTVMSALYSSLN 2008

Human  2056 KVILYCLSKPQQSLSECLGLLSILGFLQEHWDVVFATYNSNISFLLCLMHCLLLLNERSYPEGFG 2120
            ||||:||||||||||||||||:||.|||||||::|||||||:||||||||||||||.||||||||
Mouse  2009 KVILHCLSKPQQSLSECLGLLTILDFLQEHWDIIFATYNSNVSFLLCLMHCLLLLNARSYPEGFG 2073

Human  2121 LEPKPRMSTYHQVFLSPNEDVKEKRED-LPSLSDVQHNIQKTVQTLWQQLVAQRQQTLEDAFKID 2184
            ||||||::.||||||||||:||:|:|: ||||.||||:|||:|:.|||||||||:||||||||||
Mouse  2074 LEPKPRITPYHQVFLSPNEEVKDKKEEGLPSLGDVQHSIQKSVRALWQQLVAQRRQTLEDAFKID 2138

Human  2185 LSVKPGEREVKIEEVTPLWEETMLKAWQHYLASEKKSLASRSNVAHHSKVTLWSGSLSSAMKLMP 2249
            ||||.||.||||||:|||||||||:|||||||||||||||||:|.||||||.|||||||||:|||
Mouse  2139 LSVKAGEIEVKIEEITPLWEETMLRAWQHYLASEKKSLASRSSVMHHSKVTSWSGSLSSAMRLMP 2203

Human  2250 GRQAKDPECKTEDFVSCIENYRRRGQELYASLYKDHVQRRKCGNIKAANAWARIQEQLFGELGLW 2314
            |||||||||:.||||||||||||:|||||||:|||:|||||.|:||||.||||::||||||||||
Mouse  2204 GRQAKDPECRAEDFVSCIENYRRKGQELYASIYKDYVQRRKSGSIKAATAWARMREQLFGELGLW 2268

Human  2315 SQGEETKPCSPWELDWREGPARMRKRIKRLSPLEALSSGRHKESQDKNDHISQTNAENQ-----D 2374
            .|..|:..||.||||.|||||||||||:.|...|.|:.| :||||:....:||||..||     |
Mouse  2269 GQMTESTRCSRWELDGREGPARMRKRIRHLLAWEPLNLG-YKESQEGKGDVSQTNTGNQVFMTAD 2332

Human  2375 ELTLREAEGEPDEVGVDCTQLTFFPALHESLHSEDFLELCRERQVILQELLDKEKVTQKFSLVIV 2439
            |||..|||..||||||||||||||||||||||||||||||||||||||||||.|||:||..:|||
Mouse  2333 ELTTEEAESRPDEVGVDCTQLTFFPALHESLHSEDFLELCRERQVILQELLDGEKVSQKVPMVIV 2397

Human  2440 QGHLVSEGVLLFGHQHFYICENFTLSPTGDVYCTRHCLSNISDPFIFNLCSKDRSTDHYSCQCHS 2504
            ||||||||:||||..|||||||||||||||||||.|||||||||||||:||||||:||||||.|:
Mouse  2398 QGHLVSEGILLFGQHHFYICENFTLSPTGDVYCTHHCLSNISDPFIFNMCSKDRSSDHYSCQRHA 2462

Human  2505 YADMRELRQARFLLQDIALEIFFHNGYSKFLVFYNNDRSKAFKSFCSFQPSLKGKATSEDTLSLR 2569
            |:|:|||||||||||||||||||.|||||.|||||:|||||.|||.:||||||||.|:||..:||
Mouse  2463 YSDLRELRQARFLLQDIALEIFFQNGYSKLLVFYNSDRSKALKSFSTFQPSLKGKGTTEDPFNLR 2527

Human  2570 RYPGSDRIMLQKWQKRDISNFEYLMYLNTAAGRTCNDYMQYPVFPWVLADYTSETLNLANPKIFR 2634
            ::||.||.|||:||||:||||||||||||.||||.|||||||||||||||||||.|||.|||.||
Mouse  2528 KHPGFDRTMLQRWQKREISNFEYLMYLNTLAGRTYNDYMQYPVFPWVLADYTSEMLNLTNPKTFR 2592

Human  2635 DLSKPMGAQTKERKLKFIQRFKEVEKTEGDMTVQCHYYTHYSSAIIVASYLVRMPPFTQAFCALQ 2699
            |||||||||||||||||.||||:|||.|||||||||||||||||||||||||||||||||||:||
Mouse  2593 DLSKPMGAQTKERKLKFTQRFKDVEKIEGDMTVQCHYYTHYSSAIIVASYLVRMPPFTQAFCSLQ 2657

Human  2700 GGSFDVADRMFHSVKSTWESASRENMSDVRELTPEFFYLPEFLTNCNGVEFGCMQDGTVLGDVQL 2764
            ||||||||||||||||||||||:||||||||||||||||||||||||.||||||||||.||||||
Mouse  2658 GGSFDVADRMFHSVKSTWESASKENMSDVRELTPEFFYLPEFLTNCNAVEFGCMQDGTTLGDVQL 2722

Human  2765 PPWADGDPRKFISLHRKALESDFVSANLHHWIDLIFGYKQQGPAAVDAVNIFHPYFYGDRMDLSS 2829
            ||||||||||||||||:||||||||:||||||||||||||||||||:|||.|||||||||:||.|
Mouse  2723 PPWADGDPRKFISLHRQALESDFVSSNLHHWIDLIFGYKQQGPAAVEAVNTFHPYFYGDRIDLGS 2787

Human  2830 ITDPLIKSTILGFVSNFGQVPKQLFTKPHPARTAAGK-PLPGKDVSTPVSLPGHPQPFFYSLQSL 2893
            |||||||||||||:|||||||||:||||||:|...|| |.||||.||||.||||.|.|.:||.:|
Mouse  2788 ITDPLIKSTILGFISNFGQVPKQIFTKPHPSRNTTGKNPGPGKDASTPVGLPGHSQSFLHSLPAL 2852

Human  2894 RPSQVTVKDMYLFSLGSESPKGAIGHIVSTEKTILAVERNKVLLPPLWNRTFSWGFDDFSCCLGS 2958
            ||||||||||||||||||||||||||||.|||:|||||:||:|:|||||||||||||||||||||
Mouse  2853 RPSQVTVKDMYLFSLGSESPKGAIGHIVPTEKSILAVEKNKLLMPPLWNRTFSWGFDDFSCCLGS 2917

Human  2959 YGSDKVLMTFENLAAWGRCLCAVCPSPTTIVTSGTSTVVCVWELSMTKGRPRGLRLRQALYGHTQ 3023
            |||||:|||||||||||.||||||||||.|||||.|.|||:||||:.|||||||:||||||||||
Mouse  2918 YGSDKILMTFENLAAWGPCLCAVCPSPTMIVTSGASAVVCIWELSLVKGRPRGLKLRQALYGHTQ 2982

Human  3024 AVTCLAASVTFSLLVSGSQDCTCILWDLDHLTHVTRLPAHREGISAITISDVSGTIVSCAGAHLS 3088
            |||||.||||||||||||||.||||||||||:.|..||.||||||||.|||||||||||||||||
Mouse  2983 AVTCLTASVTFSLLVSGSQDRTCILWDLDHLSRVACLPVHREGISAIAISDVSGTIVSCAGAHLS 3047

Human  3089 LWNVNGQPLASITTAWGPEGAITCCCLMEGPAWDTSQIIITGSQDGMVRVWKTEDVKMSVPGRPA 3153
            ||||||||||||||||||||.|||||::||||||.|.:|||||:|||||:||||||||.||.:..
Mouse  3048 LWNVNGQPLASITTAWGPEGTITCCCIVEGPAWDASHVIITGSKDGMVRIWKTEDVKMPVPRQAV 3112

Human  3154 GEEPPAQPPSPRGHKWEKNLALSRELDVSIALTGKPSKTSPAVTALAVSRNHTKLLVGDERGRIF 3218
            .|||..:|.|||||||.||||||||||||:||:|||||.||||||||::||.:|||||||:||||
Mouse  3113 MEEPSTEPLSPRGHKWAKNLALSRELDVSVALSGKPSKASPAVTALAITRNQSKLLVGDEKGRIF 3177

Human  3219 CWSADG 3224
            ||||||
Mouse  3178 CWSADG 3183

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
WDFY4	XP_011538288.2	None
Wdfy4	XP_006519340.1	PH_BEACH	2386..2507	CDD:275391	102/120 (85%)
		Beach	2538..2819	CDD:396627	258/280 (92%)
		WD40	<2901..3099	CDD:421866	172/197 (87%)
		WD40 repeat	2936..2979	CDD:293791	35/42 (83%)
		WD40 repeat	2985..3021	CDD:293791	29/35 (83%)
		WD40 repeat	3026..3076	CDD:293791	46/49 (94%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83960833
Domainoid	1	1.000	3825	1.000	Domainoid score	I43
eggNOG	0	0.000	Not matched by this tool.
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H83473
Inparanoid	1	1.050	5181	1.000	Inparanoid score	I130
Isobase	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG41798
OrthoDB	1	1.010	-	-		D101142at2759
OrthoFinder	1	1.000	-	-		FOG0001924
OrthoInspector	1	1.000	-	-		oto113475
orthoMCL	1	0.900	-	-		OOG6_102608
Panther	1	1.100	-	-	LDO	PTHR46108
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R143
SonicParanoid	1	1.000	-	-		X1446
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	17	17.440