Protein Alignment GBA2 and CG33090

DIOPT Version :10

• Sequence 1: XP_006716872.1
• Gene: GBA2 / 57704
• HGNCID: 18986
• Length: 933
• Species: Homo sapiens
• Sequence 2: NP_788055.2
• Gene: CG33090 / 34835
• FlyBaseID: FBgn0028916
• Length: 948
• Species: Drosophila melanogaster
• Alignment Length: 923
• Identity: 377/923 - (40%)
• Similarity: 524/923 - (56%)
• Gaps: 125/923 - (13%)

Human    81 VPPFGWRICLAHEFTEKRKPFQANNVSLSNMIKHIGMGLRYLQWWYRKTHVEKKTPFIDMINSVP 145
            ||.:|.::...|.:.|||  .|....|:...:..:.:..||.. :|.|...|.:..::|......
  Fly    50 VPKYGLKLKFDHVWPEKR--IQNVRASIRQTLPMVPLVCRYAA-YYWKVSREGRRVYMDYYYMEN 111

Human   146 LRQIYGCPLGGIGGGTITRGWRGQFCRWQLNPGMYQHRTVIADQPICPLKFTVCLRREGQTVYQQ 210
            .:||||.|:||||||||.||:.|:|||:|:.||:|::..|:|:|.|..:|     ..:|.|::|.
  Fly   112 GKQIYGVPIGGIGGGTIGRGYAGEFCRFQMRPGIYEYNVVLANQFIVTIK-----DPKGCTIFQS 171

Human   211 VLS---------------------LERPSV-------LRSWNWGLCGYFAFYHALYPRAWTVYQL 247
            :||                     .:.|:.       |.:|:..:......|..||||:||.|.|
  Fly   172 LLSKCSTRDKTSDPDGDPDGERTKCQLPNCSSRAKQPLSAWHSNIEDTRCSYTGLYPRSWTEYDL 236

Human   248 PGQNVTLTCRQITPILPHDYQDSSLPVGVFVWDVENEGDEALDVSIMFSMRNGLGG-GDDAPGGL 311
            ....|.|||||::|::||:|::||||..||||.|||..|:...|||.|:.:||.|. ..||.||.
  Fly   237 SHYGVRLTCRQVSPVIPHEYRESSLPCAVFVWSVENVCDQERKVSITFTFKNGTGNKKQDAEGGA 301

Human   312 WNEPFCLERSGETVRGLLLHHPTLPNPYTMAVAARVTAATTVTHITAFDPDSTGQQVWQDLLQDG 376
            .::..    |....:|:.:.......|.:..:|.||....::|....|||...|:|:|..|.:.|
  Fly   302 ESQLI----SEGNAKGVSIRQKISEMPCSYNLACRVLPEISITRCPQFDPAGNGEQLWAQLKEHG 362

Human   377 QL-DSPTGQSTPTQKGVGIAGAVCVSSKLRPRGQCRLEFSLAWDMPRIMFGAKGQVHYRRYTRFF 440
            || :.||.::..| |.:|:  |||....|:|.....|||.||||||:|.|..|.|.|.|.||::|
  Fly   363 QLSEHPTSEALKT-KDIGV--AVCGQVALKPMASHDLEFVLAWDMPKIQFPRKMQTHTRYYTKYF 424

Human   441 GQDGDAAPALSHYALCRYAEWEERISAWQSPVLDDRSLPAWYKSALFNELYFLADGGTVWLEVLE 505
            ...||:.|.:..|||.:|:.||..|.|||.|:|:|.:||.|||.|:||:|||::||||:||:.
  Fly   425 DDSGDSGPRICEYALRQYSTWERLIDAWQRPILNDETLPDWYKCAIFNQLYFISDGGTIWLKC-- 487

Human   506 DSLPEELGRNMCHLRPTLRDYGRFGYLEGQEYRMYNTYDVHFYASFALIMLWPKLELSLQYDMAL 570
            ||   .||:.:.:..|.|. |||||||||.|||||||||||||||.||..|||.|::|||||...
  Fly   488 DS---SLGKELAYDDPRLA-YGRFGYLEGHEYRMYNTYDVHFYASPALAHLWPNLQVSLQYDFKD 548

Human   571 ATLREDLTRRRYLMSGVMAPVKRRNVIPHDIGDPDDEPWLRVNAYLIHDTADWKDLNLKFVLQVY 635
            |...|....|:.|..|.:.|.|.:|.:|||:||||:||:..:|.|.|||..||||||.|||||||
  Fly   549 AIAAELNDTRKMLYDGKVMPRKVKNCVPHDLGDPDEEPFTLINCYNIHDVNDWKDLNTKFVLQVY 613

Human   636 RDYYLTGD-----------------------------------------QN-------------- 645
            ||||:..:                                         ||
  Fly   614 RDYYVLNELAQAQSDNASKFSSIEFIDKESLYELYSQDNKRKNSADEKQQNRKSASMYINETNGK 678

Human   646 --------FLKDMWPVCLAVMESEMKFDKDHDGLIENGGYADQTYDGWVTTGPSAYCGGLWLAAV 702
                    :||.|:..|.|:||..:::|||:||||||....|||||.||..||||||.||||||:
  Fly   679 VYLMDAIGYLKAMYASCKAIMERTIEYDKDNDGLIENTKMPDQTYDSWVMDGPSAYCSGLWLAAL 743

Human   703 AVMVQMAALCGAQDIQDKFSSILSRGQEAYERLLWNGRYYNYDSSSRPQSRSVMSDQCAGQWFLK 767
            ..|..||.:....:...::..||.:|:.:.|..||||.||.:|.|...:. ::|:||..|.|:||
  Fly   744 QAMSAMATILDQPNDCLRYQDILEKGKRSLEEKLWNGSYYRFDLSHSHRD-TIMADQLCGHWYLK 807

Human   768 ACGLGEGDTEVFPTQHVVRALQTIFELNVQAFAGGAMGAVNGM-----QP--HGVPDKSSVQSDE 825
            :||.   |.|::|.::|..||:.|::.||..|..|.:||.||.     :|  .|..|.|::|::|
  Fly   808 SCGF---DYEIYPKENVRTALKRIYDNNVMGFHEGNIGAANGFIANASEPTKPGHVDNSNIQAEE 869

Human   826 VWVGVVYGLAATMIQEGLTWEGFQTAEGCYRTVWERLGLAFQTPEAYCQQRVFRSLAYMRPLSIW 890
            ||.||||.|||||||||:..|.||||.|.|:|:.:|:|:.|:||||...::.:||:.||||||||
  Fly   870 VWPGVVYALAATMIQEGMFEEAFQTAGGMYKTLSQRIGMNFETPEALYGEKRYRSIGYMRPLSIW 934

Human   891 AMQLALQQQQHKK 903
            :||:||::::.::
  Fly   935 SMQVALERRRAQR 947

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GBA2	XP_006716872.1	Glyco_hydr_116N	166..461	CDD:463496	115/324 (35%)
		DUF608	527..890	CDD:461391	193/432 (45%)
CG33090	NP_788055.2	Glyco_hydr_116N	132..445	CDD:463496	115/324 (35%)
		DUF608	505..936	CDD:461391	195/434 (45%)