DRSC/TRiP Functional Genomics Resources

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Protein Alignment GBA2 and AP-1gamma

DIOPT Version :10

Sequence 1:XP_006716872.1 Gene:GBA2 / 57704 HGNCID:18986 Length:933 Species:Homo sapiens
Sequence 2:NP_788891.2 Gene:AP-1gamma / 31842 FlyBaseID:FBgn0030089 Length:982 Species:Drosophila melanogaster


Alignment Length:388 Identity:70/388 - (18%)
Similarity:126/388 - (32%) Gaps:144/388 - (37%)


- Green bases have known domain annotations that are detailed below.


Human    41 QVTDCKSPEDSRPPKETDCC------NPEDS-------GQLMVSYEGKAMGYQVPPFGWRICL-- 90
            |:...::..:.|.....:|.      ..|||       .:|:..:   .:||.. .||...||  
  Fly    54 QIRAARTAAEERAVVNKECAYIRSTFREEDSVWRCRNIAKLLYIH---MLGYPA-HFGQLECLKL 114

Human    91 --AHEFTEKRKPF----------QANNVSLSNMIKHIGMGLRYLQWWYRKTHVEKKTPFIDMINS 143
              :..||:||..:          |..::.::|.:|:               .:...|.|:     
  Fly   115 TASTRFTDKRIGYLGAMLLLDERQDVHLLITNCLKN---------------DLNSSTQFV----- 159

Human   144 VPLRQIYGCPLGGIGGGTITRGWRGQFCRWQLNPGMYQHRTVIADQPICPLKFTVCLRREGQTVY 208
            |.|..   |.||.|....:.|....:..|...:|..|..:           |.|:|..|..:.| 
  Fly   160 VGLAL---CTLGAIASPEMARDLASEVERLMKSPNTYIRK-----------KATLCAFRVIRRV- 209

Human   209 QQVLSLERP---SVLRSWNWGLCGYFAFYHALYPRAWTVYQLPGQN-VTLTCRQITPILPHDYQD 269
            .:::.:..|   |:|...|.|:.                  :.|.. :|..|...:..|.|..:|
  Fly   210 PELMEIFLPATRSLLSEKNHGIL------------------ITGVTLITEMCENSSDTLMHFKKD 256

Human   270 SSLPVGVFVWDVENEGDEALDVSIMFSMRNGLGGG----DDAPGGLWNEPFCLERSGETVRGLLL 330
            |              |:..:..:::..::|.:.||    .|..|  .::||...:....:| :|.
  Fly   257 S--------------GNREIVPNLVRILKNLILGGYSPEHDVSG--VSDPFLQVKILRLLR-ILG 304

Human   331 HHPTLPNPYTMAVAARVTAATTVTHITAFDPDSTGQQVWQDLLQDGQLDSPTGQSTPTQKGVG 393
            |:                           |||::  :...|:|      :....:|.|.|.||
  Fly   305 HN---------------------------DPDAS--EAMNDIL------AQVATNTETSKNVG 332

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GBA2XP_006716872.1 Glyco_hydr_116N 166..461 CDD:463496 41/236 (17%)
DUF608 527..890 CDD:461391
AP-1gammaNP_788891.2 Adaptin_N 68..624 CDD:396262 68/374 (18%)
Alpha_adaptinC2 869..972 CDD:197886
Blue background indicates that the domain is not in the aligned region.

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