Protein Alignment PTPN1 and PTP1

DIOPT Version :10

• Sequence 1: NP_002818.1
• Gene: PTPN1 / 5770
• HGNCID: 9642
• Length: 435
• Species: Homo sapiens
• Sequence 2: NP_010051.1
• Gene: PTP1 / 851368
• SGDID: S000002389
• Length: 335
• Species: Saccharomyces cerevisiae
• Alignment Length: 288
• Identity: 87/288 - (30%)
• Similarity: 140/288 - (48%)
• Gaps: 53/288 - (18%)

Human    38 PKNKNRNRYRDVSPFDHSRIKLHQ-EDNDYINASLIKMEEAQRS-----YILTQGPLPNTCGHFW 96
            |:|..||||.::.|::.:|:.|.. ..|||||||.:|:....:|     ||.||||...|...||
Yeast    50 PRNDARNRYVNIMPYERNRVHLKTLSGNDYINASYVKVNVPGQSIEPGYYIATQGPTRKTWDQFW 114

Human    97 EMVWEQ---KSRGVVMLNRVMEKGSLKCAQYWPQ-----------KEE-----KEMIFEDTNLKL 142
            :|.:..   .:..:||:..::|....||.||||:           |.|     .:|....::||:
Yeast   115 QMCYHNCPLDNIVIVMVTPLVEYNREKCYQYWPRGGVDDTVRIASKWESPGGANDMTQFPSDLKI 179

Human   143 TLIS-EDIKSYYTVRQLEL--ENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSL 204
            ..:: ..:|.||||..::|  .:......:.:.||::..|.|...||.....:..   ...|.||
Yeast   180 EFVNVHKVKDYYTVTDIKLTPTDPLVGPVKTVHHFYFDLWKDMNKPEEVVPIMEL---CAHSHSL 241

Human   205 SPEHGPVVVHCSAGIGRSGTFCLADTCLLLMD-----------KRKDPSSVD-----IKKVLLEM 253
            :....|::||||||:||:|||...|.  |:.|           :..|.::.:     |::::|::
Yeast   242 NSRGNPIIVHCSAGVGRTGTFIALDH--LMHDTLDFKNITERSRHSDRATEEYTRDLIEQIVLQL 304

Human   254 RKFRMGLIQTADQLRFSYLAVIEGAKFI 281
            |..||.::||.||..|.|.|    ||::
Yeast   305 RSQRMKMVQTKDQFLFIYHA----AKYL 328

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PTPN1	NP_002818.1	PTPc-N1	16..292	CDD:350456	87/288 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	338..359
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	378..398
PTP1	NP_010051.1	PTP_fungal	79..323	CDD:350509	72/248 (29%)