Protein Alignment PTPN1 and ptpn1

DIOPT Version :10

• Sequence 1: NP_002818.1
• Gene: PTPN1 / 5770
• HGNCID: 9642
• Length: 435
• Species: Homo sapiens
• Sequence 2: NP_001017121.2
• Gene: ptpn1 / 549875
• XenbaseID: XB-GENE-950442
• Length: 433
• Species: Xenopus tropicalis
• Alignment Length: 437
• Identity: 312/437 - (71%)
• Similarity: 363/437 - (83%)
• Gaps: 11/437 - (2%)

Human     1 MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDND 65
            |:|||||.:.|:..||.:.||:||::||||||:||:|.:||.||||||||||||||||||:||||
 Frog     3 MDMEKEFHEADRKNSWGSNYQEIRNQASDFPCKVARLQENKARNRYRDVSPFDHSRIKLHREDND 67

Human    66 YINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEE 130
            |||||||||||||||||||||||||||||||||:|||||.||||||||:||||:|||||||:||:
 Frog    68 YINASLIKMEEAQRSYILTQGPLPNTCGHFWEMIWEQKSIGVVMLNRVIEKGSIKCAQYWPKKED 132

Human   131 KEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFL 195
            ..|:|:|:||||||:|||||||||:|||.||||:|||||||||||||||||||||||||||||||
 Frog   133 NSMVFDDSNLKLTLLSEDIKSYYTIRQLMLENLSTQETREILHFHYTTWPDFGVPESPASFLNFL 197

Human   196 FKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGL 260
            |||||||||:||:||:||||||||||||||||||||||||||||||||||||:|||||||:||||
 Frog   198 FKVRESGSLNPEYGPIVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKQVLLEMRKYRMGL 262

Human   261 IQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPPPEHIPPPPRPPKRILEPHNGKC- 324
            ||||||||||||||||||||||||||||:||||||:|||:|||||.|||||||||..|..|||.
 Frog   263 IQTADQLRFSYLAVIEGAKFIMGDSSVQEQWKELSNEDLDPPPEHTPPPPRPPKRTTETPNGKVY 327

Human   325 --REFFPNHQWVKEETQEDKDCPIKEE--KGSPLNAAPYGIESMSQDTEVRSRVVGGSLRGAQAA 385
              .||||  |.:.||........::|.  .|:.|::.....||...|||:|.|||...:.    :
 Frog   328 EQSEFFP--QQIVEEVIRRAVSVVEESVPDGTILSSPQQPAESTRPDTEIRRRVVDDQVH----S 386

Human   386 SPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLTAGAYLCYRFLFN 432
            :|:..|....|.::::....||.|::|:|:..||||||.|.||..::
 Frog   387 NPSPEEKLKSESEDNNKGPEWKSFVMNICMFAVLTAGACLLYRVWYH 433

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PTPN1	NP_002818.1	PTPc-N1	16..292	CDD:350456	242/275 (88%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	338..359		3/22 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	378..398		3/19 (16%)
ptpn1	NP_001017121.2	PTP_DSP_cys	18..294	CDD:475123	242/275 (88%)