DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PTPN1 and CG42327

DIOPT Version :9

Sequence 1:	NP_002818.1	Gene:	PTPN1 / 5770	HGNCID:	9642	Length:	435	Species:	Homo sapiens
Sequence 2:	NP_001036706.2	Gene:	CG42327 / 41401	FlyBaseID:	FBgn0259227	Length:	1429	Species:	Drosophila melanogaster

Alignment Length:	315	Identity:	89/315 - (28%)
Similarity:	146/315 - (46%)	Gaps:	60/315 - (19%)

- Green bases have known domain annotations that are detailed below.

Human    22 DIRHEASDFPCRVAKL----PKNKNRNRYRDVSPFDHSRIKLHQEDND----YINASLIK-MEEA 77
            |:..|..|.|..:|:.    |..:::|||.:|.|...:|:.|.::.:|    ||||:.:: ..:|
  Fly  1110 DVFEEFRDVPQIIARADEVPPGCEDKNRYANVIPLPETRVVLQRQGDDDKTEYINANYVRGPRDA 1174

Human    78 QRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKL 142
            ...||..|.||.:|...||.|:|||:||.::....:.|.|..:||:|.|.....:......:.::
  Fly  1175 PNYYIACQAPLESTTSDFWRMIWEQQSRVIIQATDLSENGIERCAEYLPPSATLDNHSSYGDYQV 1239

Human   143 TLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVR-------- 199
            ||...::|..|.:..|.|:.:..:|:||:.|:.| .||:.|||...|..:..|.:.|
  Fly  1240 TLKHREVKDRYAISTLVLKRVDGEESRELTHYWY-KWPEAGVPAEEAPIIAMLLEARSSLKSYSL 1303

Human   200 ------------------------ESGSLS---------------PEHGPVVVHCSAGIGRSGTF 225
                                    |:||.|               .:.||:.||||.|.||:||.
  Fly  1304 EQANELREKSATLETSMDADGSKAEAGSTSSHEINGNISSRSGTRSQQGPLTVHCSPGTGRTGTI 1368

Human   226 CLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSY-LAVIEGAK 279
            ..:|..:..::..|  .||||.:::..:|:.|...:||.:|..|.| :|.:..||
  Fly  1369 IASDMAIRSLETPK--RSVDIPQLVYYVRRGRASAVQTKEQYEFIYKVASMYAAK 1421

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PTPN1	NP_002818.1	PTPc	3..276	CDD:214550	87/310 (28%)
		Substrate binding. /evidence=ECO:0000250	215..221		3/5 (60%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	338..359
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	378..398
CG42327	NP_001036706.2	PTPc	1134..1415	CDD:238006	80/283 (28%)
CG42327	NP_001036706.2	Y_phosphatase	1134..1415	CDD:278528	80/283 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810