Protein Alignment PTPN1 and Ptp61F

DIOPT Version :10

• Sequence 1: NP_002818.1
• Gene: PTPN1 / 5770
• HGNCID: 9642
• Length: 435
• Species: Homo sapiens
• Sequence 2: NP_476687.1
• Gene: Ptp61F / 38160
• FlyBaseID: FBgn0267487
• Length: 548
• Species: Drosophila melanogaster
• Alignment Length: 477
• Identity: 180/477 - (37%)
• Similarity: 252/477 - (52%)
• Gaps: 86/477 - (18%)

Human     1 MEMEKEFEQIDKSGSWAAIYQDI----RHEASDFPCRVAKLPKNKNR--NRYRDVSPFDHSRIKL 59
            :::|.|::  ||...|...|::|    ..||.:.....::..::.||  ||||||:|:|||||.|
  Fly    17 LQIEAEYK--DKGPQWHRFYKEICETCDREAKEKQFSTSESERHTNRGLNRYRDVNPYDHSRIVL 79

Human    60 HQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQY 124
            .:...|||||:|:::|.|:|.||||||||.:|.||||.||||||||.|:|||::|||..:||..|
  Fly    80 KRGSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLY 144

Human   125 WPQKEEKEMIFEDTNLKLTLISEDIKSY--YTVRQLELENLTTQETREILHFHYTTWPDFGVPES 187
            ||.:...:...:..::|||:....:::|  :..|..:|.:|.||::||::.||||||||||:|.|
  Fly   145 WPNEMGADKALKLPHVKLTVELVRLETYQNFVRRWFKLTDLETQQSREVMQFHYTTWPDFGIPSS 209

Human   188 PASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLE 252
            |.:||.||.:||:||.||.:.||.||||||||||||||||.|.||:|:||.   ...::.|||.|
  Fly   210 PNAFLKFLQQVRDSGCLSRDVGPAVVHCSAGIGRSGTFCLVDCCLVLIDKY---GECNVSKVLCE 271

Human   253 MRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPPPEHIPPPPRPPKRI- 316
            :|.:|||||||||||.|||.|:|||.| .:.|.:..|..:.|...|.|.......|||.|| |:
  Fly   272 LRSYRMGLIQTADQLDFSYQAIIEGIK-KLHDPTFLDAEEPLISNDTETHTLDELPPPLPP-RVQ 334

Human   317 -----LEPHNG-------------------------KCREFFPNHQWV----------------- 334
                 |.|::|                         ....|...|..:
  Fly   335 SLNLPLAPNSGGILSLNMRAAQANGAESIGKELSKDALNNFINQHDMIHDAEVADSRPLPPLPVR 399

Human   335 -----------------KEETQEDKDC-PIKEEKGSPLNA-APYGIESMSQDTEVRSR---VVGG 377
                             :::|.||::. .|.|....|:|. .|...:..:.|....:.   |...
  Fly   400 AFNDSDSDEDYLLDDDDEDDTDEDEEYETINEHDADPVNGHVPATTQPHADDVNANNEKPAVPVD 464

Human   378 SLRGAQAASPAKGE-PSLPEKD 398
            ....|....|..|: |:.||.:
  Fly   465 EQHKANGIDPIPGQLPASPENE 486

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PTPN1	NP_002818.1	PTPc-N1	16..292	CDD:350456	146/283 (52%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	338..359		7/22 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	378..398		6/20 (30%)
Ptp61F	NP_476687.1	PTPc-N1_2	63..291	CDD:350393	131/230 (57%)