Protein Alignment PTPN1 and ptpn1

DIOPT Version :10

• Sequence 1: NP_002818.1
• Gene: PTPN1 / 5770
• HGNCID: 9642
• Length: 435
• Species: Homo sapiens
• Sequence 2: NP_570999.2
• Gene: ptpn1 / 30081
• ZFINID: ZDB-GENE-980605-23
• Length: 433
• Species: Danio rerio
• Alignment Length: 451
• Identity: 285/451 - (63%)
• Similarity: 336/451 - (74%)
• Gaps: 39/451 - (8%)

Human     3 MEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYI 67
            ||.||.:||:.|:|..:||:||.::||.||::||||:|::|||||||||||||||.|....||||
Zfish     1 MEAEFREIDEHGNWNDVYQEIRQQSSDLPCKIAKLPENRSRNRYRDVSPFDHSRICLQIGCNDYI 65

Human    68 NASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKE 132
            |||||.:|||||.||||||||||||||||||||||:||||||||||:||||:||||||||:||:|
Zfish    66 NASLISVEEAQRKYILTQGPLPNTCGHFWEMVWEQRSRGVVMLNRVIEKGSVKCAQYWPQREERE 130

Human   133 MIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFK 197
            .:|||||.:|||||||:||||||||||||||:|||||||||||||||||||||||||||||||||
Zfish   131 AVFEDTNFRLTLISEDVKSYYTVRQLELENLSTQETREILHFHYTTWPDFGVPESPASFLNFLFK 195

Human   198 VRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQ 262
            |||||.||||.|||||||||||||||||||.|||||||.:|||||||.|::||||||::||||||
Zfish   196 VRESGCLSPELGPVVVHCSAGIGRSGTFCLVDTCLLLMSQRKDPSSVRIQEVLLEMRRYRMGLIQ 260

Human   263 TADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPPPEHIPPPPRPPKRILEPHNGKCREF 327
            |||||||||||.|||||:||||:|||:.|||||:|: :.||| :.||||||.|| :|.|||  ..
Zfish   261 TADQLRFSYLAFIEGAKYIMGDTSVQESWKELSNEE-DLPPE-LTPPPRPPPRI-DPPNGK--GD 320

Human   328 FPN----HQWVKEETQEDKDCPIKEEKGSPLNAAPYGIESMSQDTEVRSRVVGGSLRGAQAASPA 388
            ..|    |.:.:..|...:.|         .|:||   ::.:...|:|.|.|...:......:..
Zfish   321 LGNSDLAHLFTESITNSAEIC---------ANSAP---KTFTDGPEIRKRTVPAEVGALPLVNEQ 373

Human   389 KGEPSLP-----------------EKDEDHALSYWKPFLVNMCVATVLTAGAYLCYRFLFN 432
            ..||.:|                 |.....|...|.|.:|::|:.|.|..||| |||..|:
Zfish   374 PDEPIIPREAPPKPPRSPPLTPATEAPTTAAQEAWSPLVVSLCLCTALAVGAY-CYRTYFH 433

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PTPN1	NP_002818.1	PTPc-N1	16..292	CDD:350456	228/275 (83%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	338..359		4/20 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	378..398		4/36 (11%)
ptpn1	NP_570999.2	PTPc-N1	14..290	CDD:350456	228/275 (83%)