Protein Alignment DDX55 and Rs1

DIOPT Version :10

• Sequence 1: XP_016875199.1
• Gene: DDX55 / 57696
• HGNCID: 20085
• Length: 618
• Species: Homo sapiens
• Sequence 2: NP_651970.1
• Gene: Rs1 / 44087
• FlyBaseID: FBgn0021995
• Length: 782
• Species: Drosophila melanogaster
• Alignment Length: 622
• Identity: 178/622 - (28%)
• Similarity: 271/622 - (43%)
• Gaps: 153/622 - (24%)

Human     2 EHVTEGSWESLPVPLHPQVLGALRELGFPYMTPVQSATIPLFMRNKDVAAEAVTGSGKTLAFVIP 66
            |.:|.....:|..||    :.|:..||:.|.||:|::|||:.:..:|:...|.||:|||.|:::|
  Fly   154 EQITSFYQMNLSRPL----MRAIGVLGYIYPTPIQASTIPVALLGRDICGCAATGTGKTAAYMLP 214

Human    67 ILEILLRREEKLKKSQVGAIIITPTRELAIQIDEVLSHFTKHFPEFSQI---LWIGGRNPGEDV- 127
            .||.||.|... .|:....:::.|||||..|:.:|    ||...:|:.|   |.|||.    ||
  Fly   215 TLERLLYRPLN-NKAITRVLVLVPTRELGAQVYQV----TKQLCQFTTIDVGLAIGGL----DVK 270

Human   128 --ERFKQQGGNIIVATPGRLEDMFRRKAE-GLDLASCVRSLDVLVLDEADRLLDMGFEASINTIL 189
              |...:|..:|::||||||.|..:.... .||      |::||:||||||:||..|...:..|:
  Fly   271 AQEAVLRQNPDIVIATPGRLIDHIKNTPSFTLD------SIEVLILDEADRMLDEYFAEQMKEII 329

Human   190 EFLPKQRRTGLFSATQTQEVENLVRAGLRNPVRVSVKEKGVAASSAQKTPSRLENYYMVCKADEK 254
            ....|.|:|.|||||.:::|::|....|..|::|.|..
  Fly   330 NSCCKTRQTMLFSATMSEQVKDLAAVSLDKPIKVFVNN--------------------------- 367

Human   255 FNQLVHFLRNHKQEKHLVFFR------------YSSGLCGRGIRDSARMCSTCACVEYYGKALEV 307
             ||.|.|  |.:||    |.|            .:|.:| |...|.   |......:.....|.:
  Fly   368 -NQQVAF--NLRQE----FIRIREDKEGDREPILASLIC-RTFHDH---CMVFVQTKKQAHRLHI 421

Human   308 L--VKGVKIMCIHGKM-KYKRNKIFMEFRKLQSGILVCTDVMARGIDIPEVNWVLQYDPPSNASA 369
            |  :.||:...:||.: :.:|.:...:|::.|..:|:.|||.|||:||..|..|:.:..|.....
  Fly   422 LLGLLGVRAGELHGNLTQQQRLESLKKFKEEQIDVLIATDVAARGLDIVGVKTVINFVMPITTEH 486

Human   370 FVHRCGRTARIGHGGSALVF-----------LLPMEESYINFLAINQKCPLQEMKPQRN-TADLL 422
            ::||.|||||.|..|.::..           ::...||.|.    |:..|.:.::..|| ...|.
  Fly   487 YIHRVGRTARAGRAGISVSLAGEKERKIVKDIIKNAESTIK----NRIIPPEIIEKYRNKLTSLE 547

Human   423 PKLKSMALADRAVFEKGMKAFVSYVQAYAKHECNLI---------FRLK---------------D 463
            |::::  :.|.   |:..:......|..:|.|..|:         |:.|               |
  Fly   548 PEIQN--ILDE---EQAERQLAKTEQQLSKTERKLLGQTNERRGWFQTKQQREAEKDRLALTTGD 607

Human   464 LDFASLARGFA-LLRMPKMPELRGKQFPDFVPVDVNTDTIPFKDKIREKQRQKLLEQQRREKTEN 527
            .|.||..:|.. .....|.||..|.          ..|..|.||          ||.:|.:|.:.
  Fly   608 EDKASGGKGKGKTAGKRKRPEYGGD----------GEDGPPVKD----------LEAKRNKKKKE 652

Human   528 EGRRKFIKNKAWSKQKAKKEKKK------KMNEKRKR 558
            |.|:|..:..|  |::|.||.:|      ||.:.|||
  Fly   653 EPRKKTPEQLA--KERAMKEIEKVSLVRAKMAKLRKR 687

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DDX55	XP_016875199.1	SrmB	16..438	CDD:440279	136/455 (30%)
		DEADc_DDX55	20..224	CDD:350718	79/210 (38%)
		DUF4217	423..480	CDD:464056	14/81 (17%)
Rs1	NP_651970.1	SrmB	156..576	CDD:440279	143/485 (29%)