Protein Alignment DDX55 and pit

DIOPT Version :10

• Sequence 1: XP_016875199.1
• Gene: DDX55 / 57696
• HGNCID: 20085
• Length: 618
• Species: Homo sapiens
• Sequence 2: NP_524446.3
• Gene: pit / 42595
• FlyBaseID: FBgn0266581
• Length: 680
• Species: Drosophila melanogaster
• Alignment Length: 548
• Identity: 184/548 - (33%)
• Similarity: 292/548 - (53%)
• Gaps: 73/548 - (13%)

Human     8 SWESLPVPLHPQVLGALRELGFPYMTPVQSATIPLFMRNKDVAAEAVTGSGKTLAFVIPILEILL 72
            |:.||...:....|.|::|:||..||.:||.::...::.:|:...|.|||||||||:||.:| |:
  Fly   186 SFASLKGAVSEATLRAIKEMGFTEMTEIQSKSLTPLLKGRDLVGAAQTGSGKTLAFLIPAVE-LI 249

Human    73 RREEKLKKSQVGAIIITPTRELAIQ----IDEVLSHFTKHFPEFSQILWIGGRNPGEDVERFKQQ 133
            .:...:.::..|.|||:|||||::|    :.|:::|   |...:..::  ||.|...:.|:. .:
  Fly   250 NKLRFMPRNGTGVIIISPTRELSMQTFGVLKELMAH---HHHTYGLVM--GGSNRQVESEKL-GK 308

Human   134 GGNIIVATPGRLEDMFRRKAEGLDLASCVRSLDVLVLDEADRLLDMGFEASINTILEFLPKQRRT 198
            |.||:|||||||.|..:...:.|     .::|..|::||.||:|::|||..:..|:..|||:|:|
  Fly   309 GINILVATPGRLLDHLQNSPDFL-----YKNLQCLIIDEVDRILEIGFEEELKQIINLLPKRRQT 368

Human   199 GLFSATQTQEVENLVRAGLRN-PVRVSVKEKGVAASSAQKTPSRLENYYMVCKADEKFNQLVHFL 262
            .|||||||..:|.|.:..|:: |:.|.|.:....|     |...||..|:||.::::...|..||
  Fly   369 MLFSATQTARIEALSKLALKSEPIYVGVHDNQDTA-----TVDGLEQGYIVCPSEKRLLVLFTFL 428

Human   263 RNHKQEKHLVFFRYSSGLCGRGIRDSARMCSTCACVEYYGKALEVLVKGVKIMCIHGKMKY-KRN 326
            :.::::|.:|||                  |:|..|:|:.:....:  .:.:..||||.|. ||.
  Fly   429 KKNRKKKVMVFF------------------SSCMSVKYHHELFNYI--DLPVTSIHGKQKQTKRT 473

Human   327 KIFMEFRKLQSGILVCTDVMARGIDIPEVNWVLQYDPPSNASAFVHRCGRTAR-IGHGGSALVFL 390
            ..|.:|...:||||:||||.|||:|||:|:|::|||||.:...::||.||||| .|..|.||:.:
  Fly   474 TTFFQFCNAESGILLCTDVAARGLDIPQVDWIVQYDPPDDPREYIHRVGRTARGSGTSGHALLLM 538

Human   391 LPMEESYINFLAINQKCPLQEMK-PQRNTADLLPKLKSMALADRAVFEKGMKAFVSYVQAYAKHE 454
            .|.|..::.:|.. .|.||.|.: ..:..||:..:|:.:...:..:.:...:||.|||:||..|:
  Fly   539 RPEELGFLRYLKA-AKVPLNEFEFSWQKIADIQLQLEKLIAKNYFLNQSAKEAFKSYVRAYDSHQ 602

Human   455 CNLIFRLKDLDFASLARGFALLRMP-----------KMPELRGKQFPDFVPVDVNTDTIPFKDKI 508
            ...||.:..||..::|:.|..|..|           :.||.|           |......|..|:
  Fly   603 LKQIFNVNTLDLQAVAKSFGFLVPPVVDLKVGAAKRERPEKR-----------VGGGGFGFYKKM 656

Human   509 REKQRQKLLEQQRREKTENEGR-RKFIK 535
            .|....|    ||..|..|..: :||::
  Fly   657 NEGSASK----QRHFKQVNRDQAKKFMR 680

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DDX55	XP_016875199.1	SrmB	16..438	CDD:440279	151/429 (35%)
		DEADc_DDX55	20..224	CDD:350718	80/208 (38%)
		DUF4217	423..480	CDD:464056	17/67 (25%)
pit	NP_524446.3	DEADc_DDX18	198..395	CDD:350700	80/208 (38%)
		SF2_C_DEAD	408..537	CDD:350174	57/148 (39%)
		DUF4217	570..627	CDD:464056	16/56 (29%)