Protein Alignment DDX55 and Dbp45A

DIOPT Version :10

• Sequence 1: XP_016875199.1
• Gene: DDX55 / 57696
• HGNCID: 20085
• Length: 618
• Species: Homo sapiens
• Sequence 2: NP_476927.1
• Gene: Dbp45A / 35917
• FlyBaseID: FBgn0010220
• Length: 521
• Species: Drosophila melanogaster
• Alignment Length: 612
• Identity: 166/612 - (27%)
• Similarity: 266/612 - (43%)
• Gaps: 130/612 - (21%)

Human    16 LHPQVLGALRELGFPYMTPVQSATIPLFMRNKDVAAEAVTGSGKTLAFVIPILEILLRREEKLKK 80
            |.|.::..|.:||....||:|...||..:..:|....|.||||||.||.:|||       |:|.:
  Fly    14 LRPWLVKQLTKLGLKGATPIQQKCIPAILAGQDCIGAAKTGSGKTFAFALPIL-------ERLSE 71

Human    81 SQVG--AIIITPTRELAIQIDEVLSHFTKHFPEFSQILWI------GGRNPGEDVERFKQQGGNI 137
            ..|.  |:::|||.|||.||.|       .|....|.:.:      ||.:...:.::..|: .:|
  Fly    72 EPVSHFALVLTPTHELAYQISE-------QFLVAGQAMGVRVCVVSGGTDQMVESQKLMQR-PHI 128

Human   138 IVATPGRLEDMFRRKAEGLDLASCVRSLDVLVLDEADRLLDMGFEASINTILEFLPKQRRTGLFS 202
            :||.||||.|    ...|.|..| ..:|..||:|||||:|:..|:.|::.|...|||.|:...||
  Fly   129 VVAMPGRLAD----HLTGCDTFS-FDNLKYLVVDEADRMLNGDFDESLSIIERCLPKTRQNLFFS 188

Human   203 ATQTQEVENLVRAGLRNPVRVSVKEKGVAASSAQKTPSRLENYYMVCKADEKFNQLVHFLRNHKQ 267
            ||    :::.::.....|:.....|  .:..|...|...|:..|::|...::...|:..||.:::
  Fly   189 AT----MKDFIKESSIFPIASDCFE--WSQDSDVATVETLDQRYLLCADYDRDMVLIEALRKYRE 247

Human   268 EK---HLVFFRYSSGLCGRGIRDSARMCSTCACVEYYGKALEVLVKGVKI--MCIHGKMKYK-RN 326
            |.   :::.|..:...|                     :.|.:.:|.::|  :|:||.|:.| |.
  Fly   248 ENENANVMIFTNTKKYC---------------------QLLSMTLKNMEIDNVCLHGFMRQKERV 291

Human   327 KIFMEFRKLQSGILVCTDVMARGIDIPEVNWVLQYDPPSNASAFVHRCGRTARIGHGGSAL-VFL 390
            .....|:..|...|:.|||.|||:|||.|..|:.:..|.....::||.|||||.|..|.:: :|.
  Fly   292 AALSRFKSNQIRTLIATDVAARGLDIPSVELVMNHMLPRTPKEYIHRVGRTARAGRKGMSISIFR 356

Human   391 LPMEESYINFLAINQKCPLQEMKPQRNTADLLPKLKSMALADRAVFEKGMKAFVSYVQAYAKHEC 455
            .|.:   :..||        .::.:.||     ||....:..|.|....|:..|:      :.|.
  Fly   357 FPRD---LELLA--------AIEEEINT-----KLTEHPIDQRMVERIFMQVNVT------RRES 399

Human   456 NLIFRLKDLDFASLARGFALLRMPKMPELRGKQFPDFVPVDVNTDTIPFKDKIREKQRQKLLEQQ 520
            .:  :|.:.||...|:.:    ..|...:.||. ||           ..:...|:||:.||.|.:
  Fly   400 EM--QLDNNDFDERAQNY----RRKTWIMEGKD-PD-----------QMEALYRKKQKDKLREIR 446

Human   521 RREKTEN-------EGRRKFIKNKAWSKQKAKKEKKKKMNEKRKREEGSDIEDEDMEELLNDTRL 578
            |:.|.::       ||:......:..|...|:.|||.|...:..:|:             ..|:.
  Fly   447 RKRKLQHAEPAASEEGKALLQDERFKSVDSARFEKKGKGRSRATQED-------------TPTKP 498

Human   579 LKKLKKGKITEEEFEKGLLTTGKRTIK 605
            ||:|.|        ||.:...|:..:|
  Fly   499 LKRLNK--------EKPVAQKGRADVK 517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DDX55	XP_016875199.1	SrmB	16..438	CDD:440279	128/436 (29%)
		DEADc_DDX55	20..224	CDD:350718	71/211 (34%)
		DUF4217	423..480	CDD:464056	11/56 (20%)
Dbp45A	NP_476927.1	SrmB	9..381	CDD:440279	126/429 (29%)