Protein Alignment TNRC6C and gw

DIOPT Version :10

• Sequence 1: XP_047292441.1
• Gene: TNRC6C / 57690
• HGNCID: 29318
• Length: 1959
• Species: Homo sapiens
• Sequence 2: NP_726596.1
• Gene: gw / 43808
• FlyBaseID: FBgn0051992
• Length: 1384
• Species: Drosophila melanogaster
• Alignment Length: 1506
• Identity: 405/1506 - (26%)
• Similarity: 565/1506 - (37%)
• Gaps: 431/1506 - (28%)

Human   653 VLSNTGWGQTPVKQNTAWEFEESPRSERKN-----------DNGTEAWGCAATQASNSGGKNDGS 706
            :.|..|||...|.|:|.||...||....|:           :|||:.|        .|..:|.|.
  Fly     5 LFSQDGWGCQHVNQDTNWEVPSSPEPANKDAPGPPMWKPSINNGTDLW--------ESNLRNGGQ 61

Human   707 IMNSTNTSSVSGWVNAPPAA--VPANTGWGDSNNKAPSG--PGVWG---DSISSTAVSTAAAAKS 764
                             |||  || ...||.:    ||.  .|.||   |...|::|.|..|.
  Fly    62 -----------------PAAQQVP-KPSWGHT----PSSNLGGTWGEDDDGADSSSVWTGGAV-- 102

Human   765 GHAWSGAA---NQEDKSPTWGEPPKPKSQHWGDGQRSNPAWSAGGGDWADSSSVLGHLGDGKKNG 826
            .:|.||||   ||...:...|.........||.|.......|.||.   .||::.|..|    ..
  Fly   103 SNAGSGAAVGVNQAGVNVGPGGVVSSGGPQWGQGVVGVGLGSTGGN---GSSNITGSSG----VA 160

Human   827 SGWDADSNRSGSGWNDTTRSGNSGWGNS---TNTKANPGTNWGET---------LKP-------- 871
            :|...:|:.:|:||.|.......|.|.|   .|.:...|...|.|         :.|
  Fly   161 TGSSGNSSNAGNGWGDPREIRPLGVGGSMDIRNVEHRGGNGSGATSSDPRDIRMIDPRDPIRGDP 225

Human   872 --------GPQQNWASKPQDNNVSNWG-----------GAASVKQTGTG---------WIGGPVP 908
                    |..:.|...||.::....|           .:.||..:|:|         .:.|.:|
  Fly   226 RGISGRLNGTSEMWGHHPQMSHNQLQGINKMVGQSVATASTSVGTSGSGIGPGGPGPSTVSGNIP 290

Human   909 VK-------------QKD-SSEATGWEEPSPPSIRRKM-EIDDGTSAWGDPS-------NYNNKT 951
            .:             .|| |.:.:||||||||..||.: ..|||||.||..:       ::.:.|
  Fly   291 TQWGPAQPVSVGVSGPKDMSKQISGWEEPSPPPQRRSIPNYDDGTSLWGQQTRVPAASGHWKDMT 355

Human   952 VNMWDRNNPVIQSSTTT---------NTTTTTTTTTSNTTHRVETPP---PHQAGTQLNRSPLLG 1004
            .:: .|::.:::..:.|         |:........||....|..|.   |...|.|....   |
  Fly   356 DSI-GRSSHLMRGQSQTGGIGIAGVGNSNVPVGANPSNPISSVVGPQARIPSVGGVQHKPD---G 416

Human  1005 PGRKVSSG-------------WGE--------MPNVHSKTENSWGEPSSPSTLVDNGTAAWGKPP 1048
            ....|.||             ||:        .|:..|.:.|:|.:..|.|||..|   :|..|.
  Fly   417 GAMWVHSGNVGGRNNVAAVTTWGDDTHSVNVGAPSSGSVSSNNWVDDKSNSTLAQN---SWSDPA 478

Human  1049 SSGSGWGDHPAEPPVAFGRAGAPVAASALCKPASKSMQEGWGSGG---DEMNLSTSQWEDEEGDV 1110
            ..|..||:..::||                   |.|...||.:..   |.::|. |:|....|.:
  Fly   479 PVGVSWGNKQSKPP-------------------SNSASSGWSTAAGVVDGVDLG-SEWNTHGGII 523

Human  1111 WNNAASQESTSSCSSWGNAPKKGLQKGMKTSGKQDEAWIMSRLIKQ------LTDMGFPREPAEE 1169
            ..:...|:..            ||..||...       |.:.:|||      |.:.||.:|..|.
  Fly   524 GKSQQQQKLA------------GLNVGMVNV-------INAEIIKQSKQYRILVENGFKKEDVER 569

Human  1170 ALKSNNMNLDQAMSAL-LEKKVDVD-----KRGLG-VTDHNGMAAKPLGCRPPISKESSVDRPTF 1227
            ||...|||:::|...| ....:.:|     ...|| ..|||             |..||
  Fly   570 ALVIANMNIEEAADMLRANSSLSMDGWRRHDESLGSYADHN-------------SSTSS------ 615

Human  1228 LDKDGGLV-EEPTPSPFLPSPSLKLPLSHSALPSQALGGIASGLGMQNLNSS-----RQIPSGNL 1286
                ||.. ..|..|   ..||:..|  |:.|.:. :||.|...|..|.|.:     :.:..|..
  Fly   616 ----GGFAGRYPVNS---GQPSMSFP--HNNLMNN-MGGTAVTGGNNNTNMTALQVQKYLNQGQH 670

Human  1287 GM------FGNSGAAQARTMQQPPQPPVQPLNS--------SQPSLRAQVPQFLSPQVQAQLLQF 1337
            |:      .|||.|......|......|....|        :|||  .|..:.|..|:     |.
  Fly   671 GVAVGPQAVGNSSAVSVGFGQNTSNAAVAGAASVNIAANTNNQPS--GQQIRMLGQQI-----QL 728

Human  1338 AAKNIGLNPALLTSPINPQHMTMLNQLYQLQLAYQRLQIQQQMLQAQRNVSGSMRQQEQQVARTI 1402
            |..:..::..:||.|:.   .|.||.|.||....:.||..||.|....||:      ...|...|
  Fly   729 AIHSGFISSQILTQPLT---QTTLNLLNQLLSNIKHLQAAQQSLTRGGNVN------PMAVNVAI 784

Human  1403 TNLQQQIQQHQRQL--AQALLVKQPPPPPPPPHLSLHPSAGKSAMDSFPSHPQTPGLPDLQTKEQ 1465
            :..:||||..|.|:  .||:.|||.         ::.|:       |....||...||.:..
  Fly   785 SKYKQQIQNLQNQINAQQAVYVKQQ---------NMQPT-------SQQQQPQQQQLPSVHL--- 830

Human  1466 QSSPNTFAPYPLAGLNPNMNVNSMDMTGGLSVKDPSQSQSRLPQWTHPNSMDNLPSAASPLEQNP 1530
            .:|.|.:.....|..|...|.:.:::......:..|..||||.||       .||.....:..:.
  Fly   831 SNSGNDYLRGHDAINNLQSNFSELNINKPSGYQGASNQQSRLNQW-------KLPVLDKEINSDS 888

Human  1531 SKHGAIPGGLSIGPPGKSSIDDSYGRYDLIQNSESPASPPVAVPHSWSRAKSDSDKISNGSSIN- 1594
            ::....||.........:|..:|.|    :||..           :||..:|..|...:.||.|
  Fly   889 TEFSRAPGATKQNLTANTSNINSLG----LQNDS-----------TWSTGRSIGDGWPDPSSDNE 938

Human  1595 ---WP---------------PEFHPGVPWKGLQNIDPENDPDVTPGSVPTGP-TINTTIQDVNRY 1640
               |.               .||.||.||||.|....|:||.:|||||...| :||:|.:|.:
  Fly   939 NKDWSVAQPTSAATAYTDLVQEFEPGKPWKGSQIKSIEDDPSITPGSVARSPLSINSTPKDAD-- 1001

Human  1641 LLKSGVRVMNPDTATTLLSAVFGSAGSSPPSSQNATLPSSSAWPLSASGYSSSFSSIASAPSVAG 1705
                                :|.:.|.:.|:.    ||     |||.|..:.||:...:.||
  Fly  1002 --------------------IFANTGKNSPTD----LP-----PLSLSSSTWSFNPNQNYPS--- 1034

Human  1706 KLSDIKSTWSSGPTSHTQASLSHELWKVPRNSTAPTRPPPGLT-------NPKPSS----TWGAS 1759
                  .:||.   :..|.:.:.|||..|.|.::...||||||       |...|:    |.||:
  Fly  1035 ------HSWSD---NSQQCTATSELWTSPLNKSSSRGPPPGLTANSNKSANSNASTPTTITGGAN 1090

Human  1760 PLGWTSSYSSG-----SAWSTDTSGRT---SSWLVLRNLTPQIDGSTLRTLCLQHGPLITFHLNL 1816
              ||....|.|     :.|   |.|.|   ||||:|:|||.||||.||||||:|||||::||..|
  Fly  1091 --GWLQPRSGGVQTTNTNW---TGGNTTWGSSWLLLKNLTAQIDGPTLRTLCMQHGPLVSFHPYL 1150

Human  1817 TQGNAVVRYSSKEEAAKAQKSLHMCVLGNTTILAEFAGEEEVNRFLAQGQALPPTSSWQSSSASS 1881
            .||.|:.:|:::|||.|||.:|:.|||.||||.||...|.||...:   |.||.|.|..|||.:|
  Fly  1151 NQGIALCKYTTREEANKAQMALNNCVLANTTIFAESPSENEVQSIM---QHLPQTPSSTSSSGTS 1212

Human  1882 QPRLSAAGSSHGLVRSDAGHWNAPCLGGKGSSELLWGGVPQYSSSLWGPPSADDSRVIG---SPT 1943
            ...:...|:|    .::|...:|.||.|..|.... |......|...|..|.::|...|   |..
  Fly  1213 GGNVGGVGTS----ANNANSGSAACLSGNNSGNGN-GSASGAGSGNNGNSSCNNSAAGGGSSSNN 1272

Human  1944 PLTTLLPGDLL 1954
            .:||:...:|:
  Fly  1273 TITTVANSNLV 1283

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TNRC6C	XP_047292441.1	COG4625	182..>589	CDD:443664
		ser_rich_anae_1	<460..>630	CDD:468206
		Ago_hook	1038..1148	CDD:463088	22/112 (20%)
		UBA_TNR6C	1151..1188	CDD:270469	15/43 (35%)
		M_domain	1230..1459	CDD:432890	66/250 (26%)
		TNRC6-PABC_bdg	1468..1781	CDD:465195	90/348 (26%)
		RRM_TNRC6C	1777..1864	CDD:410112	52/89 (58%)
gw	NP_726596.1	Ago_hook	388..525	CDD:463088	38/162 (23%)
		UBA_GAWKY	551..585	CDD:270470	11/33 (33%)
		M_domain	614..849	CDD:432890	73/285 (26%)
		TNRC6-PABC_bdg	844..1117	CDD:465195	88/342 (26%)
		RRM_GW182_like	1116..1185	CDD:409869	44/68 (65%)