DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LRRC4C and CYR1

DIOPT Version :9

Sequence 1:	NP_001245348.1	Gene:	LRRC4C / 57689	HGNCID:	29317	Length:	640	Species:	Homo sapiens
Sequence 2:	NP_012529.3	Gene:	CYR1 / 853452	SGDID:	S000003542	Length:	2026	Species:	Saccharomyces cerevisiae

Alignment Length:	313	Identity:	79/313 - (25%)
Similarity:	140/313 - (44%)	Gaps:	48/313 - (15%)

- Green bases have known domain annotations that are detailed below.

Human    19 NRALFDPLLVVLLALQLLVVAGL-VRAQTCPSVCSCSNQFSKVICVRKNLREVPDGIS--TNTRL 80
            |..:|.||..:..:::||.:..: :||...||..:.:.:...:...|..:|:||:.|.  :|..:
Yeast   826 NANIFLPLEFIESSIKLLSLRMVNIRASKFPSNITKAYKLVSLELQRNFIRKVPNSIMKLSNLTI 890

Human    81 LNLHENQIQIIKVNSFKHLRHLEILQLSRN---HIRTIEIGAFNGLANLNTLELFDNRLTTIPNG 142
            |||..|:::.:.. .|..|::|::|.||.|   |...:    .|...||..::|..|::.::|..
Yeast   891 LNLQCNELESLPA-GFVELKNLQLLDLSSNKFMHYPEV----INYCTNLLQIDLSYNKIQSLPQS 950

Human   143 AFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGELKRLSYISEGAFEGLSNLRYLNLAMC 207
            . .||.||.::.|.:|.:..|..  .:.:..||.|:| ...|:|.|...|    |||:.|.|...
Yeast   951 T-KYLVKLAKMNLSHNKLNFIGD--LSEMTDLRTLNL-RYNRISSIKTNA----SNLQNLFLTDN 1007

Human   208 NLREIPNLTPLIKLDELDLSGNHLSAIRPGSFQGL--MHLQKLWMIQSQIQVIERNAFDNLQSLV 270
            .:....:..|  ||..|::..|.:::|   ||:..  .::..|.:.::|:..|.......|..|.
Yeast  1008 RISNFEDTLP--KLRALEIQENPITSI---SFKDFYPKNMTSLTLNKAQLSSIPGELLTKLSFLE 1067

Human   271 EINLAHNNLTLLPHDL----------------------FTPLHHLERIHLHHN 301
            ::.|..||||.||.::                      .:.|..|..:.||.|
Yeast  1068 KLELNQNNLTRLPQEISKLTKLVFLSVARNKLEYIPPELSQLKSLRTLDLHSN 1120

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LRRC4C	NP_001245348.1	LRRNT	47..80	CDD:214470	8/34 (24%)
		PPP1R42	65..235	CDD:411060	48/174 (28%)
		LRR 1	77..98		6/20 (30%)
		leucine-rich repeat	78..101	CDD:275380	6/22 (27%)
		LRR 2	101..122		6/23 (26%)
		leucine-rich repeat	102..125	CDD:275380	7/25 (28%)
		LRR 3	125..146		5/20 (25%)
		leucine-rich repeat	126..149	CDD:275380	6/22 (27%)
		LRR 4	149..170		5/20 (25%)
		leucine-rich repeat	150..173	CDD:275380	4/22 (18%)
		LRR 5	173..195		8/21 (38%)
		leucine-rich repeat	174..198	CDD:275380	8/23 (35%)
		LRR 6	198..219		5/20 (25%)
		leucine-rich repeat	199..220	CDD:275380	4/20 (20%)
		LRR_8	220..279	CDD:404697	14/60 (23%)
		LRR 7	220..241		7/20 (35%)
		leucine-rich repeat	221..244	CDD:275380	6/24 (25%)
		LRR 8	244..265		3/20 (15%)
		leucine-rich repeat	245..268	CDD:275380	4/22 (18%)
		LRR_8	267..>301	CDD:404697	12/55 (22%)
		LRR 9	268..289		8/42 (19%)
		leucine-rich repeat	269..290	CDD:275380	8/42 (19%)
		LRRCT	301..>339	CDD:214507	1/1 (100%)
		IG	360..443	CDD:214652
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	463..483
CYR1	NP_012529.3	Ad_cyc_g-alpha	368..418	CDD:369912
		RA_PHLPP_like	678..776	CDD:340473
		PLN00113	792..>1273	CDD:215061	79/313 (25%)
		leucine-rich repeat	796..817	CDD:275380
		leucine-rich repeat	818..839	CDD:275380	4/12 (33%)
		leucine-rich repeat	840..864	CDD:275380	6/23 (26%)
		leucine-rich repeat	865..887	CDD:275380	5/21 (24%)
		leucine-rich repeat	888..910	CDD:275380	6/22 (27%)
		leucine-rich repeat	911..933	CDD:275380	7/25 (28%)
		leucine-rich repeat	934..956	CDD:275380	6/22 (27%)
		leucine-rich repeat	957..978	CDD:275380	4/22 (18%)
		leucine-rich repeat	979..1018	CDD:275380	14/45 (31%)
		leucine-rich repeat	1019..1041	CDD:275380	6/24 (25%)
		leucine-rich repeat	1042..1065	CDD:275380	4/22 (18%)
		leucine-rich repeat	1066..1088	CDD:275380	8/21 (38%)
		leucine-rich repeat	1089..1111	CDD:275380	1/21 (5%)
		leucine-rich repeat	1167..1187	CDD:275380
		leucine-rich repeat	1191..1211	CDD:275380
		leucine-rich repeat	1236..1258	CDD:275380
		leucine-rich repeat	1259..1287	CDD:275380
		PP2C	1374..1617	CDD:395385
		CYCc	1613..1825	CDD:214485
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910