DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LRRC4C and lron-8

DIOPT Version :9

Sequence 1:	NP_001245348.1	Gene:	LRRC4C / 57689	HGNCID:	29317	Length:	640	Species:	Homo sapiens
Sequence 2:	NP_491676.2	Gene:	lron-8 / 181983	WormBaseID:	WBGene00020693	Length:	341	Species:	Caenorhabditis elegans

Alignment Length:	413	Identity:	90/413 - (21%)
Similarity:	171/413 - (41%)	Gaps:	101/413 - (24%)

- Green bases have known domain annotations that are detailed below.

Human    22 LFDPLLVVLLALQLLVVAGLVRAQTCPSVCSCSNQFSKVICVRKN----LREVPDGISTNTRLLN 82
            :.:.:|||       |:.|:|.|.   :..||.....::.|..||    |::..|.:..:|  ||
Worm     1 MIEKVLVV-------VIIGVVGAY---AQGSCRTDQHEMTCRGKNSLHDLKKDQDYLEVDT--LN 53

Human    83 LHENQIQIIK--VNSFKHLRHLEILQLSRNHIRTIEIGAFNGLANLNTLELFDNRLTTIPNGAFV 145
            :|:.::.:..  |....:|.||.:|..:.|.|..|....|:.:.|:..|.|..|:::......|.
Worm    54 VHQAKLDLTDDLVPDGINLSHLTLLNATDNQITRIGRRGFDKIRNMQFLYLSINQISHSQPDPFQ 118

Human   146 YLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGELKRLSYISEGAFEGLSNLRYLNLAMCNLR 210
            .|.|||.|.:.:                  .|| |.::..|.:....|...::
Worm   119 ALEKLKRLEMND------------------ALD-GNMEEKSDMLRNFFHSKNS------------ 152

Human   211 EIPNLTPLIKLDELDLSGNHLSAIRPGSFQGLMHLQKLWMIQSQIQVIE--RNAFDNLQSLVEIN 273
                   .:.|.:::|:.|.:..|.|.:|.|:..||:|.:..::|...:  |.....|::|:
Worm   153 -------FVHLAQIELNKNKIEGIYPKTFCGIQGLQRLELSNNRIPSFDFARTCLKELKALM--- 207

Human   274 LAHNNLTLLPHDLFTPLHHLERIHLHHNPWNCNC---------DILWLSWWIKDMAPSNTACCAR 329
            ||.|.:..:|.|::..|..|..:.:.:||.:|:|         |:::|:       .::|    :
Worm   208 LAGNLIQKIPADIWDFLPSLSSLDISNNPIDCDCATIRLLSGDDVVFLN-------QADT----K 261

Human   330 CNTPPNLKGRYIGELDQNYF-TCYAPVIVEPPADLNVTEGMAAELKCRASTSLTSVSWITPNGTV 393
            |.:||.|:|:.|.||.::|. |...|                   :.:||.....|.::...|.:
Worm   262 CASPPELEGKRIFELSRDYCKTTRNP-------------------RGKASFFQFLVLFVIAVGIL 307

Human   394 MTHGAYKVRIAVLSDGTLNFTNV 416
            ..:..|:.|...:|...:.:||:
Worm   308 WLYKKYRERTRHMSSVPVGYTNL 330

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LRRC4C	NP_001245348.1	LRRNT	47..80	CDD:214470	8/36 (22%)
		PPP1R42	65..235	CDD:411060	35/175 (20%)
		LRR 1	77..98		5/22 (23%)
		leucine-rich repeat	78..101	CDD:275380	6/24 (25%)
		LRR 2	101..122		7/20 (35%)
		leucine-rich repeat	102..125	CDD:275380	6/22 (27%)
		LRR 3	125..146		5/20 (25%)
		leucine-rich repeat	126..149	CDD:275380	5/22 (23%)
		LRR 4	149..170		4/20 (20%)
		leucine-rich repeat	150..173	CDD:275380	3/22 (14%)
		LRR 5	173..195		5/21 (24%)
		leucine-rich repeat	174..198	CDD:275380	5/23 (22%)
		LRR 6	198..219		0/20 (0%)
		leucine-rich repeat	199..220	CDD:275380	0/20 (0%)
		LRR_8	220..279	CDD:404697	17/60 (28%)
		LRR 7	220..241		6/20 (30%)
		leucine-rich repeat	221..244	CDD:275380	7/22 (32%)
		LRR 8	244..265		5/22 (23%)
		leucine-rich repeat	245..268	CDD:275380	6/24 (25%)
		LRR_8	267..>301	CDD:404697	8/33 (24%)
		LRR 9	268..289		6/20 (30%)
		leucine-rich repeat	269..290	CDD:275380	6/20 (30%)
		LRRCT	301..>339	CDD:214507	11/46 (24%)
		IG	360..443	CDD:214652	9/57 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	463..483
lron-8	NP_491676.2	LRR	<71..>237	CDD:227223	45/206 (22%)
		leucine-rich repeat	75..98	CDD:275380	6/22 (27%)
		leucine-rich repeat	99..122	CDD:275380	5/22 (23%)
		leucine-rich repeat	123..158	CDD:275380	9/72 (13%)
		leucine-rich repeat	159..179	CDD:275380	6/19 (32%)
		leucine-rich repeat	180..202	CDD:275380	5/21 (24%)
		leucine-rich repeat	203..226	CDD:275380	8/25 (32%)
		LRRCT	235..282	CDD:214507	16/57 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	73	1.000	Inparanoid score	I4325
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.960