DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CHD8 and mit1

DIOPT Version :10

Sequence 1:NP_001164100.1 Gene:CHD8 / 57680 HGNCID:20153 Length:2581 Species:Homo sapiens
Sequence 2:NP_595385.1 Gene:mit1 / 2541336 PomBaseID:SPBP35G2.10 Length:1418 Species:Schizosaccharomyces pombe


Alignment Length:1327 Identity:353/1327 - (26%)
Similarity:550/1327 - (41%) Gaps:322/1327 - (24%)


- Green bases have known domain annotations that are detailed below.


Human   526 KTKGKSKLN-TITPVVGKKRKR---NTS-----SDNSDVEVMPAQSPREDEESSIQKRRSNR--- 578
            :|:..|:.| .|.|:..|..|.   ||.     |...|:.:.|:.:.||.....:...:|.|   
pombe   253 ETRNYSQQNGFICPLCSKNSKDVLCNTGFVSGVSSGQDLVIPPSLADRESLSILVNYCKSIRFRC 317

Human   579 -QVKRKKYTEDLDIKITDDEEEEEVDVTGPIKPEPILPEPVQEPDGETLPSMQFFVENPSEEDAA 642
             :.:|.:|...||              :.|:..:..:...:::           .|.|.......
pombe   318 FRCRRVEYFFYLD--------------SNPLSIQRTITHFIKK-----------LVCNECSMHPC 357

Human   643 IVDKVLSMRIVKKELPSGQYTE------------AEEFFVKYKNYSYLHCEWATISQLEKDKRIH 695
            .::::::.|.:....||.....            :.|:||:.|..|||||.|.:.|.|.      
pombe   358 DIEEIIAWRTLNSLYPSKATLSNNFVSTSDLSFWSREYFVRSKGKSYLHCFWCSASWLA------ 416

Human   696 QKLKRFKTKMAQMRHF------FHEDEEPFNP-DYVEVDRILDESHSIDKDNG------------ 741
                  ...:|:.::|      .::..:|..| .|..:|::.|..:...|:..            
pombe   417 ------GISLAKKKNFDGLENASYDATKPIIPVSYTIIDKVWDVQYRSGKNARTAKYKTKKHQLK 475

Human   742 --EPVIYYLVKWCSLPYEDSTWELKEDVDEGKIREFKRIQSRHPELKRVNRPQASAWKK------ 798
              ..|.:..|.|..|.|..|.||                    |..|..:|.:..||.|      
pombe   476 AISEVTFAFVSWRGLTYYMSNWE--------------------PPPKETDRNRWKAWLKGYSDLL 520

Human   799 ------------LELSHEYKN-----------RNQLREYQLEGVNWLLFNWYNRQNCILADEMGL 840
                        :.:...:.|           ...|..|||:|:|||...||....|||||||||
pombe   521 ECLWIEKAPTASINIDLPFTNLEWHSQPSFIKGGTLMPYQLKGLNWLYLRWYTHHPCILADEMGL 585

Human   841 GKTIQSIAFLQEVYNVGIHGPFLVIAPLSTITNWEREFNTWT---EMNTIVYHGSLASRQMIQQY 902
            |||:|.|:|:..::......|.|||.|.:|:.|||||...|.   ::|.:|  ||..:|.:::.|
pombe   586 GKTVQVISFISVLFYRHKCFPVLVIVPHATVANWERELKKWAPFLQINVLV--GSEKNRSLVRDY 648

Human   903 EMYCKDSRGRLI----PGAYKFDALITTFEMILSDCPELREIEWRCVIIDEAHRLKNRNCKLLDS 963
                     |||    |.......|:.:...:..:...||:.:|:.:|:||..||||....|...
pombe   649 ---------RLINQKDPKHVSTHVLVISASNVEREISLLRKFQWKVLIVDEGQRLKNDQSSLFYY 704

Human   964 LKHMDLEHKVLLTGTPLQNTVEELFSLLHFLEPSQFPSESEFLKDFGDLKTEEQVQKLQAILKPM 1028
            |..:..:.|:|||||||||.|.|||:||.||.|.:. :.:|..|.:..:.| |:|.:|..||||.
pombe   705 LSSVKSDFKLLLTGTPLQNNVRELFNLLQFLNPMKI-NAAELEKRYSIIDT-EKVTELHQILKPF 767

Human  1029 MLRRLKEDVEKNLAPKQETIIEVELTNIQKKYYRAILEKNFSFLSKGAGHTN--------MPNLL 1085
            .|||:|.:|..|...|.|.||.:.:|.:||..|::||.||.|.|....|:.|        ..:|.
pombe   768 FLRRVKSEVLDNFPTKVEVIIPLSMTPVQKGLYKSILSKNLSLLRNITGYANTSSSGGQRTTSLN 832

Human  1086 NTMMELRKCCNHPYLIN-GAEEKILTEFREACHIIPHDFHLQAMVRSAGKLVLIDKLLPKLKAGG 1149
            |.:|:|||...|||:.: ..|::.|          |::..::::..::.|.:::..|:|||...|
pombe   833 NILMQLRKTLAHPYIYSPDIEDRNL----------PYELAMRSLEEASCKFLILRLLVPKLITRG 887

Human  1150 HKVLIFSQMVRCLDILEDYLIQRRYLYERIDGRVRGNLRQAAIDRFSKPDSDRFVFLLCTRAGGL 1214
            |::|:|||.::.||||||:...:...|.|.||......||:|||.|:.|:|:...|||.|||||:
pombe   888 HRILLFSQFIQQLDILEDWFEYKNIAYARFDGASSEMERQSAIDSFNAPNSELSCFLLSTRAGGV 952

Human  1215 GINLTAADTCIIFDSDWNPQNDLQAQARCHRIGQSKAVKVYRLITRNSYEREMFDKASLKLGLDK 1279
            ||||.:|||.||.|.|:||..|:||.||.||.||.|.|.|:.|.||:|.|.::...|..||.||.
pombe   953 GINLASADTVIILDPDFNPHQDMQAIARAHRYGQKKKVLVFVLTTRDSVEEKIIQNAQKKLVLDH 1017

Human  1280 AVLQSMSGRDGNITGIQQFSKKEIEDLLRKGAYAAIMEEDDEGS-KFCEEDIDQILLRRTTTITI 1343
            .:::|:   |.|     ..|:|::|.:||.||.|...|..||.| |:.|..::.::        .
pombe  1018 LIVESL---DQN-----HNSEKDLESILRHGARALFEEAGDEPSIKYNEYSVELLI--------S 1066

Human  1344 ESEGKGSTFAKASFVASENRTDISLDDPNFWQKWAKKADLDMDLLNSKNNLVIDTPRVRKQTRHF 1408
            |:|.:..|        |.:.:||..:...|::.|..|                          |.
pombe  1067 EAEKQEDT--------STDESDIKSNKFGFFRVWDNK--------------------------HI 1097

Human  1409 STLKDDDLVEFSDLESEDDERPRSRRHDRHHAYGRTDCFRVEKHLLVYGWGRWRDILSHGRFKRR 1473
            |:                           :|       :.|::::||.....|..||.. |.|..
pombe  1098 SS---------------------------NH-------YEVKENVLVDEEDVWSVILKQ-REKDA 1127

Human  1474 MTERDVETIC-RAILVYCLLHYRGDENIKGFIWDLISPAENGKTKE--LQNHSGLSIPVPRGRKG 1535
            |.|:..||.. |.:..:..:||..|.||          .:|....:  :.:.|....|.|...:.
pombe  1128 MLEKTDETTSNRRLRAHHKIHYGEDLNI----------YDNSDDTDYTVNDRSSPGSPFPIETET 1182

Human  1536 KKVKSQSTFDIHKADWIRKYNPDTLFQDESYKKHLKHQCNKVLLRVRMLYYLRQEVIGDQAEKVL 1600
            ....:.:..|..|..:....|.:.|..:...:|......:.:|.: .:|....:|   |:..|.|
pombe  1183 ISSITDTLSDKQKLKYDSSVNIENLNDESDSQKSADVHFDSILAK-SLLATTPKE---DEFNKTL 1243

Human  1601 GGAIASEIDIWFPVVDQLEVPTTWWDSEADKSLLIG--VFKHGYEKYNTMRADPALCFLEK---- 1659
                 |.|::  .|.::|.......|||..   ||.  ||...||            .:||    
pombe  1244 -----STINL--EVANKLTSSEYINDSEMQ---LIDDPVFYPPYE------------IIEKNHQL 1286

Human  1660 AGRPDDKAIAAEHRVLDNFSDIVE----GVDFDKDCEDPEYKPLQ----------GPPKDQDDEG 1710
            .||...||:.....:|.:.||.|.    |:.     ..|.:.||.          |.|.....:.
pombe  1287 VGRSLSKAVLDNFFLLSSLSDNVRCRCCGIK-----HLPAHCPLSIVPLEICFLCGTPHFSGRDT 1346

Human  1711 DPLMMMDEEISVIDGDEAQVTQQPGHL 1737
            .|::...|.|..:. |....:::|.|:
pombe  1347 CPMLRNKEAIYRLK-DSLSKSREPFHI 1372

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CHD8NP_001164100.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 22..114
PHA03247 <68..280 CDD:223021
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 253..283
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 349..392
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 429..582 16/68 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 596..615 1/18 (6%)
CD1_tandem_CHD5-9_like 638..703 CDD:349315 15/76 (20%)
CD2_tandem_CHD5-9_like 721..779 CDD:349310 13/72 (18%)
PLN03142 810..>1409 CDD:215601 222/615 (36%)
DEXHc_CHD8 811..1032 CDD:350818 90/227 (40%)
DEAH box. /evidence=ECO:0000255|HAMAP-Rule:MF_03071 948..951 2/2 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1692..1712 5/29 (17%)
Interaction with FAM124B. /evidence=ECO:0000255|HAMAP-Rule:MF_03071, ECO:0000269|PubMed:23285124 1789..2302
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1991..2116
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2189..2229
BRK 2310..2354 CDD:197800
BRK 2379..2419 CDD:197800
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2481..2581
mit1NP_595385.1 PHD 214..268 CDD:214584 5/14 (36%)
CD_CSD 359..426 CDD:475127 16/78 (21%)
PLN03142 546..>1086 CDD:215601 218/586 (37%)
zf-CCCH_7 1235..1329 CDD:376012 31/123 (25%)
zf-CCCH_6 1331..1383 CDD:436598 8/43 (19%)
Blue background indicates that the domain is not in the aligned region.

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