DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HCN3 and Hcn3

DIOPT Version :9

Sequence 1:	NP_065948.1	Gene:	HCN3 / 57657	HGNCID:	19183	Length:	774	Species:	Homo sapiens
Sequence 2:	NP_446137.1	Gene:	Hcn3 / 114245	RGDID:	620691	Length:	780	Species:	Rattus norvegicus

Alignment Length:	781	Identity:	734/781 - (93%)
Similarity:	742/781 - (95%)	Gaps:	8/781 - (1%)

- Green bases have known domain annotations that are detailed below.

Human     1 MEAEQRPAAGASEGATPGLEAVPPVAPPPATAASGPIPKSGPEPKRRHLGTLLQPTVNKFSLRVF 65
            ||.|.|||.|..|.|||..| .||.||..|.||||.:|:|.||||||.|||||||||||||||||
  Rat     1 MEEEARPAVGDGEAATPARE-TPPAAPAQARAASGGVPESAPEPKRRQLGTLLQPTVNKFSLRVF 64

Human    66 GSHKAVEIEQERVKSAGAWIIHPYSDFRFYWDLIMLLLMVGNLIVLPVGITFFKEENSPPWIVFN 130
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat    65 GSHKAVEIEQERVKSAGAWIIHPYSDFRFYWDLIMLLLMVGNLIVLPVGITFFKEENSPPWIVFN 129

Human   131 VLSDTFFLLDLVLNFRTGIVVEEGAEILLAPRAIRTRYLRTWFLVDLISSIPVDYIFLVVELEPR 195
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   130 VLSDTFFLLDLVLNFRTGIVVEEGAEILLAPRAIRTRYLRTWFLVDLISSIPVDYIFLVVELEPR 194

Human   196 LDAEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLL 260
            |||||||||||||||||||||||||||||||||||:|||||||||||||||||||||||||||||
  Rat   195 LDAEVYKTARALRIVRFTKILSLLRLLRLSRLIRYMHQWEEIFHMTYDLASAVVRIFNLIGMMLL 259

Human   261 LCHWDGCLQFLVPMLQDFPPDCWVSINHMVNHSWGRQYSHALFKAMSHMLCIGYGQQAPVGMPDV 325
            |||||||||||||||||||.|||||:|.|||||||||||||||||||||||||||||||||||||
  Rat   260 LCHWDGCLQFLVPMLQDFPSDCWVSMNRMVNHSWGRQYSHALFKAMSHMLCIGYGQQAPVGMPDV 324

Human   326 WLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADTRQRIHEYYEH 390
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   325 WLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADTRQRIHEYYEH 389

Human   391 RYQGKMFDEESILGELSEPLREEIINFTCRGLVAHMPLFAHADPSFVTAVLTKLRFEVFQPGDLV 455
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   390 RYQGKMFDEESILGELSEPLREEIINFTCRGLVAHMPLFAHADPSFVTAVLTKLRFEVFQPGDLV 454

Human   456 VREGSVGRKMYFIQHGLLSVLARGARDTRLTDGSYFGEICLLTRGRRTASVRADTYCRLYSLSVD 520
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   455 VREGSVGRKMYFIQHGLLSVLARGARDTRLTDGSYFGEICLLTRGRRTASVRADTYCRLYSLSVD 519

Human   521 HFNAVLEEFPMMRRAFETVAMDRLLRIGKKNSILQRKRSEPSPG-SSGGIMEQHLVQHDRDMARG 584
            ||||||||||||||||||||||||.||||||||||||||||||| ||||:|||||||||||||||
  Rat   520 HFNAVLEEFPMMRRAFETVAMDRLRRIGKKNSILQRKRSEPSPGSSSGGVMEQHLVQHDRDMARG 584

Human   585 VRGRAPSTGAQLSGKPVLWEPLVHAPLQAAAVTSNVAIALTHQRGPLPLSPDSPATLLARSAWRS 649
            :||.||.|||:|||||||||||||||||||||||||||||||||||||||||||||||||||.||
  Rat   585 IRGLAPGTGARLSGKPVLWEPLVHAPLQAAAVTSNVAIALTHQRGPLPLSPDSPATLLARSARRS 649

Human   650 AGSPASPLVPVRA------GPWASTSRLPAPPARTLHASLSRAGRSQVSLLGPPPGGGGRRLGPR 708
            |||||||||||||      |||||||||||||||||||||||.||||||||||||||||||||||
  Rat   650 AGSPASPLVPVRAGPLLARGPWASTSRLPAPPARTLHASLSRTGRSQVSLLGPPPGGGGRRLGPR 714

Human   709 GRPLSASQPSLPQRATGDGSPGRKGSGSERLPPSGLLAKPPRTAQPPRPPVPEPATPRGLQLSAN 773
            |||||||||||||||||||||.|||||||||||||||||||.|.||.|..||||.||||.|:|||
  Rat   715 GRPLSASQPSLPQRATGDGSPRRKGSGSERLPPSGLLAKPPGTVQPSRSSVPEPVTPRGPQISAN 779

Human   774 M 774
            |
  Rat   780 M 780

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HCN3	NP_065948.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..48		28/46 (61%)
		Involved in subunit assembly. /evidence=ECO:0000250	46..91		43/44 (98%)
		Ion_trans_N	49..91	CDD:285597	41/41 (100%)
		Ion_trans	111..358	CDD:278921	242/246 (98%)
		Interaction with KCTD3. /evidence=ECO:0000250\|UniProtKB:O88705	354..774		402/426 (94%)
		Crp	422..>560	CDD:223736	136/137 (99%)
		CAP_ED	428..536	CDD:237999	107/107 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	682..774		81/91 (89%)
Hcn3	NP_446137.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..47		28/46 (61%)
		Involved in subunit assembly. /evidence=ECO:0000250	45..90		43/44 (98%)
		Ion_trans_N	48..90	CDD:285597	41/41 (100%)
		Ion_trans	110..357	CDD:278921	242/246 (98%)
		Interaction with KCTD3. /evidence=ECO:0000250\|UniProtKB:O88705	353..780		402/426 (94%)
		Crp	421..>557	CDD:223736	134/135 (99%)
		CAP_ED	427..535	CDD:237999	107/107 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	549..569		18/19 (95%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	687..780		82/92 (89%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83696112
Domainoid	1	1.000	526	1.000	Domainoid score	I6422
eggNOG	1	0.900	-	-		E1_KOG0498
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H22453
Inparanoid	1	1.050	1457	1.000	Inparanoid score	I2899
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG48787
OrthoDB	1	1.010	-	-		D20242at314146
OrthoFinder	1	1.000	-	-		FOG0000897
OrthoInspector	1	1.000	-	-		oto139738
orthoMCL	1	0.900	-	-		OOG6_101339
Panther	1	1.100	-	-	LDO	PTHR45689
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X717
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	18.270