|
Human 77 VWVPDEQDAYVEAEV------KSEATGGRVTV-------ETKDQKVLMVREAELQPMNPPRFDLL 128
||:|||::.:|:.|: |::.||....: .|:...::.||.:::.|:||..||.:
Yeast 13 VWIPDEKEVFVKGELMSTDINKNKFTGQEEQIGIVHPLDSTEVSNLVQVRISDVFPVNPSTFDKV 77
Human 129 EDMAMMTHLNEASVLHNLRQRYARWMIYTYSGLFCVTINPYKWLPVYTASVVAAYKGK--RRSDS 191
|:|:.:|||||.|||:||.:||...:||||||||.|.||||..|.:|:...:..|..| |.|.|
Yeast 78 ENMSELTHLNEPSVLYNLEKRYDCDLIYTYSGLFLVAINPYHNLNLYSEDHINLYHNKHNRLSKS 142
Human 192 ----------PPHIYAVADNAYNDMLRSKGRLDSSPTADPDLGPGRPLPRQPVHADHQFLATKTG 246
||||:|:|:.||.::| |:|: |.|.....:.|.|:....:.: .|:||:.|.
Yeast 143 RLDENSHEKLPPHIFAIAEEAYENLL-SEGK-DQSILVTGESGAGKTENTKKI---LQYLASITS 202
Human 247 G---------------TLEDQIIEANPAMEAFGNAKTLRNDNSSRFGKFIRIHFGPSGKLASADI 296
| :.|.:|:::||.:|:||||:|:||:|||||||||:|.|...|.:..|.|
Yeast 203 GSPSNIAPVSGSSIVESFEMKILQSNPILESFGNAQTVRNNNSSRFGKFIKIEFNEHGMINGAHI 267
Human 297 DSYLLEKSRVIFQLPGERSYHVYYQILSG-RKPELQDMLLLSMNPYDYHFCS---QGVIT-VDNM 356
:.|||||||::.|...||:||::||:||| ...||:::.|.|.|..||...| |.:|. ::::
Yeast 268 EWYLLEKSRIVHQNSKERNYHIFYQLLSGLDDSELKNLRLKSRNVKDYKILSNSNQDIIPGINDV 332
Human 357 NDGEELIATDHAMDILGFSVDEKCACYKIVGALLHFGNMKFKQKQREEQAEADGTESADKAAYLM 421
.:.:||:: |::|:|||.|:....:::|..:|..||::| ...|.|||......|| ....:
Yeast 333 ENFKELLS---ALNIIGFSKDQIRWIFQVVAIILLIGNIEF-VSDRAEQASFKNDVSA--ICSNL 391
Human 422 GVSSGDLLKGLLHPRVRVGNEYVTKGQSVEQVVFAVGALAKATYDRLFRWLVSRINQTLDTKLPR 486
||...|....:|.||.:.|.|:|::.::.:|..|.:.||::..|:|||.::|..||:.||.....
Yeast 392 GVDEKDFQTAILRPRSKAGKEWVSQSKNSQQAKFILNALSRNLYERLFGYIVDMINKNLDHGSAT 456
Human 487 QFFIGVLDIAGFEIFEFNSFEQLCINFTNEKLQQFFNQHMFVLEQEEYKREGIDWVFIDFGLDLQ 551
..:||:||||||||||.|||||||||:||||||||||.|||||||.||.:|.|.|.:||:|.|||
Yeast 457 LNYIGLLDIAGFEIFENNSFEQLCINYTNEKLQQFFNNHMFVLEQSEYLKENIQWDYIDYGKDLQ 521
Human 552 PCIDLIEKVRRLRLSDVGGPHSYSFCSQPLGILSILEEECMFPKASDASFRAKLYDNHAGKSPNF 616
..|||||. .|| |.|:|.:|:||.:.||::|.||.:||.......|..|
Yeast 522 LTIDLIES---------KGP--------PTGVLPLLDEEAVLPKSTDESFYSKLISTWDQNSSKF 569
Human 617 QQPRPDKKRKYQAHFEVVHYAGVVPYSIVGWLEKNKDPLNETVVPIFQKSQNRLLATLYENYAGS 681
|:.:.:..|.:.||||.|.|::.|||.|||||||:.::.:...|||.:::.|::.....
Yeast 570 ------KRSRLKNGFILKHYAGDVEYTVEGWLSKNKDPLNDNLLSLLSSSQNDIISKLFQPEGEK 628
Human 682 CSTEPPKSGVK----EKRKKAASFQTVSQLHKENLNKLMTNLRATQPHFVRCIVPNENKTPGVMD 742
.|:...::.:. :|..:.::|:|.|..|:|....|:..|.:|.|||||||:||..|.....:
Yeast 629 SSSAGVEANISNQEVKKSARTSTFKTTSSRHREQQITLLNQLASTHPHFVRCIIPNNVKKVKTFN 693
Human 743 AFLVLHQLRCNGVLEGIRICRQGFPNRLLYTDFRQRYRILNPSAIPDDTFMDSRKATEK-----L 802
..|:|.||||||||||||:.|:|:|||:.:.:|.||||||.|......||....||:.| |
Yeast 694 RRLILDQLRCNGVLEGIRLAREGYPNRIAFQEFFQRYRILYPENSTTTTFSSKLKASTKQNCEFL 758
Human 803 LGSLDLDHTQYQFGHTKVGALWDQGWPWLWRSHWAGFMRMVGGYPGCLPLRPQVFFKAGLLGVLE 867
|.||.||...|:.|:|| :|||||:|..||
Yeast 759 LTSLQLDTKVYKIGNTK------------------------------------LFFKAGVLADLE 787
Human 868 ELRDQRLAKVLTLLQARSRG---------RLMRLEYQRLLGGRDALFTIQWNIRAFN-AVKNWSW 922
:.:|.:|..::..|.|..|| .|.:|:..|::|. ..|.:| .||...|
Yeast 788 KQKDVKLNNIMIKLTATIRGYTVRKEITYHLQKLKKTRVIGN---------TFRLYNRLVKEDPW 843
Human 923 MKLFFKMKPLLRSAQAEEELAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQAE 987
..||.::||||.|:...........::..|:..|...|:|::.|||.:.....|..:....|..|
Yeast 844 FNLFIRIKPLLTSSNDMTRTKKFNEQINKLKNDLQEMESKKKFLEEKNQKTVNELENTQDLLNQE 908
Human 988 QDNLADAEERCHLLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLEL 1052
::||...| .|..:||..||.|: |..|||
Yeast 909 KENLRKNE-----------SLLNRVKTSSETLQ------------------------KQFDDL-- 936
Human 1053 TLAKAEKEKQATENKVKNLTEEMAALDESVARLTKEK----KALQEAHQQALGDLQAEEDRVSAL 1113
.:||:: :::|| :.|:||||:..|..:...:|.:.|
Yeast 937 ---VSEKDE-----------------------ISREKLEVAQNLEEAHQKIQGLQETIREREATL 975
Human 1114 TKAKLR---LEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKK 1175
.|...: |.:|:.||.|.:.:|:..:...:.:|.|||.::|..::.:....::.:...:||..
Yeast 976 EKLHSKNNELIKQISDLNCDISKEQSSQSLIKESKLKLENEIKRLKDVINSKEEEIKSFNDKLSS 1040
Human 1176 KDSEL---------------SQL-SLRVEDEQLLG---------AQMQKKIKELQARAEELEEEL 1215
.:.:| |:| ||..|:..|.. |.:..::|..::...:::|::
Yeast 1041 SEEDLDIKLVTLEKNCNIAMSRLQSLVTENSDLRSKNENFKKEKAALNNQLKNKESELLKMKEKI 1105
Human 1216 EAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRREL-EEAALRHE 1279
:..:...|...|||.:|..|..:::..|:|........:...:|.:.|....:||. |:...:..
Yeast 1106 DNHKKELATFSKQRDDAVSEHGKITAELKETRIQLTEYKSNYQKIKEEYSNFQRETKEQEQKKRN 1170
Human 1280 ATVAALR-RKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAE---- 1339
:.|.:|. .|..|..|.|.:::. :.|.|.| |:..:.:..|:.:..|:.:.::
Yeast 1171 SLVESLNDSKIKELEARLSQEIS----LNQYLNK-----RISGNSVETNISSTRRSTSYSDDPLD 1226
Human 1340 ----------------KLCRTYEDQLSEAKIKVEEL---QRQLADASTQRGRLQTESGELSRLLE 1385
::.|..|:::.|.|..:..| :.:||.:|.:..:::.:..:|.:|::
Yeast 1227 KEDIIKKYYDLQLAFTEITRNLENEIEEKKNLISRLRFTETRLASSSFEDQKIKAQMKKLKKLIQ 1291
Human 1386 --------------------EKECLISQLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQALR 1430
:||..|::| ...::.|:|||:.|::|.....:|:.||
Yeast 1292 DMDPSIPLDSILNEPLDNCPDKESDINKL-------MLEVDYLKRQLDIETRAHYDAENAISAL- 1348
Human 1431 HDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALR------ 1489
|.:..:.|.| .|.::::: ::.|:||.. :|.:.||:..|.:.||
Yeast 1349 ---------HSKFRKIQGE----SSLSSSDI--YKLKFEASE-ERVKSLEDKLKTMPLRDRTNLP 1397
Human 1490 ----------LQEAEEGVEAANAKCSSLEKAKLR-LQTES----EDVTLELERATSAAAALDKKQ 1539
:.:.||.: :...||..||: :..|| ..:||:|.::.|..|.|.::.
Yeast 1398 VGDIIKNRDSISKYEEEI-----RYYKLENYKLQEILNESNGKLSQLTLDLRQSKSKEALLSEQL 1457
Human 1540 RHLERALEERRRQEEEMQRELEAAQRESRGL-----GTELFRLRHGHEEALEALETLKRENKNLQ 1599
..|::.||...||:|.:...::..:::.... |.|| ||| |.:.||:..:.:.||:.
Yeast 1458 DRLQKDLESTERQKELLSSTIKQQKQQFENCMDDLQGNEL-RLR----EHIHALKQAEEDVKNMA 1517
Human 1600 EEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEET--KTLRIQLELSQVK 1662
..|..|..|.....|.|.|.| :|..:..::|:|| :..|:| .||
Yeast 1518 SIIEKLKTQNKQKEKLIWERE----------------MERNDSDMQLQETLLELKRVQ----DVK 1562
Human 1663 AEVDRKLAEKDEECANLRRNHQ------RAVESLQASLDAETRARNEALRLKKKMEGDLNDLELQ 1721
..:...||...|..:.:....| |..|.|..||.|||..:.|...||.|:|...||.|.:
Yeast 1563 KILSDDLAHLKERLSAVEDRSQYTDEINRLKEELNCSLKAETNLKKEFATLKYKLETSTNDSEAK 1627
Human 1722 LGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLAAELEELRAALE 1786
:....:|. |...::...|:.:..|:.
Yeast 1628 ISDLLKQL---------------------DHYTKVVEMLNNEKDAIS------------------ 1653
Human 1787 QGERSRRLAEQELLEATERLNL----LHSQNTGLLNQKKKLEADLAQLSG--EVEEAA-----QE 1840
|||:||.:..|.||. |..:...|...|::||:||.|.:. ::..|| |:
Yeast 1654 -------LAEKELYQKYEALNTECESLKGKIVSLTKIKQELESDLNQKTDALQISNAALSSSTQK 1711
Human 1841 RREAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQTVRELQARLEEAEQ--AALRGGKK 1903
.:|..||.| .:.|.|:.:.:.::....:.|||:.:....:.:.::.:| ..|....:
Yeast 1712 NKEITEKIK-------YLEETLQLQMEQNSRNGELVKTLQASCNGYKDKFDDEKQKNIDLYEENQ 1769
Human 1904 QVQK----LEAKVRELEAELDAEQKKHAEALKGVRKHERRVK---ELAYQAEEDRKNLARMQDLV 1961
.:|| |:.:::.|...|....:|:| .|..:.:.|..|. :|.|:..:..|:|.| .|
Yeast 1770 TLQKLNTDLQLQLKNLHERLSDTTEKNA-WLSKIHELENMVSLETDLKYEEMKKNKSLER---AV 1830
Human 1962 DKLQSKVKSYKRQFEEAEQQANTNLAKYRKA----QHELDDAEERADMAETQANK 2012
::||:| ..|..:..:.||.|.:::.:| :.::.|.|:.....|.:..|
Yeast 1831 EELQTK----NSQQTDVIELANKNRSEFEEATLKYEAQISDLEKYISQQELEMKK 1881
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