DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment EP400 and Chd3

DIOPT Version :10

Sequence 1:NP_056224.3 Gene:EP400 / 57634 HGNCID:11958 Length:3123 Species:Homo sapiens
Sequence 2:NP_649111.1 Gene:Chd3 / 40111 FlyBaseID:FBgn0023395 Length:892 Species:Drosophila melanogaster


Alignment Length:1412 Identity:234/1412 - (16%)
Similarity:400/1412 - (28%) Gaps:701/1412 - (49%)


- Green bases have known domain annotations that are detailed below.


Human   854 IKLRVELEEKRKK-ALNLQKVSRRGKELRPKGFDALQESSLDSGMSGRKRKASISLTDDEVDDEE 917
            ::||....|||:: .:....:|....|..|:|...|..:|:.:....|......||  :|:||::
  Fly   100 VELRTSKGEKRREYFIKWHGMSYWHCEWIPEGQMLLHHASMVASFQRRSDMEEPSL--EELDDQD 162

Human   918 ETIEEEEANEGVVDHQTELSNLAKEAELP---LLDLMKLYEGAFLPSSQWPRPKPDGEDTSGEED 979
            ..:.|.....|:......:..:...:|.|   .:.|:|..|.::             .|:|.|.:
  Fly   163 GNLHERFYRYGIKPEWLLVQRVINHSEEPNGGTMYLVKWRELSY-------------NDSSWERE 214

Human   980 ADDCPGDRESRKDLVLIDSLFIMDQFKAAERMNIGKPNAKDIADVTAVAEAILPKGSARVTTSVK 1044
            :|..||..::            :..:|.....|.|:..               .:.:..:..:.|
  Fly   215 SDSIPGLNQA------------IALYKKLRSSNKGRQR---------------DRPAPTIDLNKK 252

Human  1045 F-NAPSLLYGA---LRDYQKIGLDWLAKLYRKNLNGILADEAGLGKTVQIIAFFAHLACNEGNW- 1104
            : :.|..|..|   |..:|..|:.||...:.:.:..|||||.|||||:|.:.|...| ..||:. 
  Fly   253 YEDQPVFLKEAGLKLHPFQIEGVSWLRYSWGQGIPTILADEMGLGKTIQTVVFLYSL-FKEGHCR 316

Human  1105 GPHLVVVRSCNILKWELELKRWCPGLKILSYIG-------------SHRELKAK-RQEWAEPNSF 1155
            ||.|:.|....:..||.||:.|.|.|..::|:|             |..|:..| .:|......|
  Fly   317 GPFLISVPLSTLTNWERELELWAPELYCVTYVGGKTARAVIRKHEISFEEVTTKTMRENQTQYKF 381

Human  1156 HVCITSYTQFFRGLTAFTR-VRWKCLVIDEMQRVKGMTERHWEAVFTLQSQQRLLLIDSPLHNTF 1219
            :|.:||| :|.....||.. :.|..||:||..|::....:.:..:...:...:|||..:||.|..
  Fly   382 NVMLTSY-EFISVDAAFLGCIDWAALVVDEAHRLRSNQSKFFRILSKYRIGYKLLLTGTPLQNNL 445

Human  1220 LELWTMVHFLVPGISRPY--LSSPLRAPSEESQDYYHKVVIRLHRVTQPFILRRTKRDVEKQLTK 1282
            .||:.:::||..|.....  ..:.....|:|.|      |.|||.:.:|.:|||.|.||.|.:..
  Fly   446 EELFHLLNFLSSGKFNDLQTFQAEFTDVSKEEQ------VKRLHEILEPHMLRRLKADVLKSMPP 504

Human  1283 KYEHVLKCRLSNRQKALYEDVILQPGTQEALK---SGHFVNVLSILVRLQRICNHPGLVEPRHPG 1344
            |.|.:::..||:.||..|:.::.:  ..:||.   .|...::|:|::.|::.||||.|       
  Fly   505 KSEFIVRVELSSMQKKFYKHILTK--NFKALNQKGGGRVCSLLNIMMDLRKCCNHPYL------- 560

Human  1345 SSYVAGPLEYPSASLILKALERDFWKEADLSMFDLIGLENKITRHEAELLSKKKIPRKLMEEIST 1409
                     :|||:           :||.:|                                  
  Fly   561 ---------FPSAA-----------EEATIS---------------------------------- 571

Human  1410 SAAPAARPAAAKLKASRLFQPVQYGQKPEGRTVAFPSTHPPRTAAPTTASAAPQGPLRGRPPIAT 1474
                                                                             
  Fly   572 ----------------------------------------------------------------- 571

Human  1475 FSANPEAKAAAAPFQTSQASASAPRHQPASASSTAASPAHPAKLRAQTTAQASTPGQPPPQPQAP 1539
                                                                             
  Fly   572 ----------------------------------------------------------------- 571

Human  1540 SHAAGQSALPQRLVLPSQAQARLPSGEVVKIAQLASITGPQSRVAQPETPVTLQFQGSKFTLSHS 1604
                                   |||    :.:::|:|..                         
  Fly   572 -----------------------PSG----LYEMSSLTKA------------------------- 584

Human  1605 QLRQLTAGQPLQLQGSVLQIVSAPGQPYLRAPGPVVMQTVSQAGAVHGALGSKPPAGGPSPAPLT 1669
                                                                             
  Fly   585 ----------------------------------------------------------------- 584

Human  1670 PQVGVPGRVAVNALAVGEPGTASKPASPIGGPTQEEKTRLLKERLDQIYLVNERRCSQAPVYGRD 1734
                                                                             
  Fly   585 ----------------------------------------------------------------- 584

Human  1735 LLRICALPSHGRVQWRGSLDGRRGKEAGPAHSYTSSSESPSELMLTLCRCGESLQDVIDRVAFVI 1799
                                                                             
  Fly   585 ----------------------------------------------------------------- 584

Human  1800 PPVVAAPPSLRVPRPPPLYSHRMRILRQGLREHAAPYFQQLRQTTAPRLLQFPELRLVQFDSGKL 1864
                                                                         ||||
  Fly   585 -------------------------------------------------------------SGKL 588

Human  1865 EALAILLQKLKSEGRRVLILSQMILMLDILEMFLNFHYLTYVRIDENASSEQRQELMRSFNRD-R 1928
            :.|:.:|::||::..|||:.|||..||::||.||......|.|||.:...:.||:.:..||.. .
  Fly   589 DLLSKMLKQLKADNHRVLLFSQMTKMLNVLEHFLEGEGYQYDRIDGSIKGDLRQKAIDRFNDPVS 653

Human  1929 RIFCAILSTHSRTTGINLVEADTVVFYDNDLNPVMDAKAQEWCDRIGRCKDIHIYRLVSGNSIEE 1993
            ..|..:|||.:...||||..||||:.:|:|.||..|.:|.....|:|:.|.:.|||.|:.||:||
  Fly   654 EHFVFLLSTRAGGLGINLATADTVIIFDSDWNPHNDVQAFSRAHRMGQKKKVMIYRFVTHNSVEE 718

Human  1994 K----------------------------------LLKNGTKDLIREVAAQG---NDYSMAFLTQ 2021
            :                                  :|:.||:||.::..::.   :|.::|.|..
  Fly   719 RIMQVAKHKMMLTHLVVRPGMGGMTTNFSKDELEDILRFGTEDLFKDGKSEAIHYDDKAVADLLD 783

Human  2022 RTIQELFEVYSPMDDAGFPVKAEEFVVLSQEPSVTETIAPKIARPFIEALKSIEY-LEEDAQKSA 2085
            ||.:.:.|..|                              .|..::.:.|...| .:||.::  
  Fly   784 RTNRGIEEKES------------------------------WANEYLSSFKVASYATKEDHEE-- 816

Human  2086 QEGVLGPHTDALSSDSENMPCDEEPSQLEELADFMEQLTPIEKYALNYLELFHTSIEQEKERNSE 2150
                   |.| .::|:||    .:|...|.|....:...|                :::|:::.:
  Fly   817 -------HDD-YNNDAEN----TDPFYWENLMGKSQPKLP----------------KKQKKQSQQ 853

Human  2151 DAVMTAVRAWEFWNLKTLQEREARLRLEQEEAELLTYTREDAYSMEY 2197
            ..|          :::::..:..|:|            :|..||.:|
  Fly   854 SQV----------DVESIMGKGKRIR------------KEIDYSNQY 878

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EP400NP_056224.3 EP400_N 1..469 CDD:434938
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..65
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 125..154
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 212..261
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 282..359
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 509..558
PAT1 518..>780 CDD:401645
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 597..622
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 648..734
HSA 764..835 CDD:214727
HepA 849..>1338 CDD:440319 131/512 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 879..931 13/51 (25%)
Interactions with RUVBL1 and RUVBL2 915..1329 110/441 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 961..988 6/26 (23%)
DEAD-like_helicase_N 1055..1271 CDD:475120 71/233 (30%)
DEAH box-like 1183..1186 2/2 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1431..1546 0/114 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1751..1771 0/19 (0%)
SF2_C_SNF 1861..1986 CDD:350180 52/125 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2083..2108 5/24 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2251..2275
Interaction with ZNF42. /evidence=ECO:0000250 2488..2753
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2488..2566
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2629..2652
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2785..2833
SP1-4_N <2840..3065 CDD:425404
PRK12323 <3004..>3123 CDD:481241
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3079..3123
Chd3NP_649111.1 PHD2_CHD_II 37..79 CDD:277007
CD_CSD 82..146 CDD:475127 11/45 (24%)
CD2_tandem_CHD3-4_like 176..230 CDD:349309 11/78 (14%)
PLN03142 266..>768 CDD:215601 168/1010 (17%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.