|
Human 30 AHPNPPPSPAAPFAPSA-SPSAPQSPSYQIQQLMNRSPATGQNVNITLQSVGPVVGGNQQITLAP 93
|.|:|..||..| |.| ||.||.|.|
Fly 2 ASPSPANSPMPP--PQAPSPMAPPSQS-------------------------------------- 26
Human 94 LPLPSPTSPGFQFSAQPRRFEHGSPSYIQVTSPLSQQVQTQSPTQPSPG-PGQALQNVRAGAPGP 157
|.|||.|| :.|..| .|| |.| |.|| ||.....::.|.||.
Fly 27 -PAPSPHSP----------YPHQQP------GPL------QGP--PPPGHPGAYGHPMQHGPPGQ 66
Human 158 GLGLCSSSPTGGFVDASVLVRQISLSPSSGGHFVFQDGSGLTQIAQGAQVQLQHPGTPITVRERR 222
| ..||.:
Fly 67 G---------------------------PPGHHM------------------------------- 73
Human 223 PSQPHTQSGGTIH----HLGPQSPAAAGGAGLQPLASPSHITTANLPPQISSIIQGQLVQQQQVL 283
.||.| |.|. |:|.|.|.. |..:.|. .:|....|.|.|...:..|
Fly 74 --PPHHQ--GMIFSKGPHMGMQMPPT--GPNMSPY--QTHGMPPNAPTQPCIVSPG--------- 121
Human 284 QGPPLPRPLGFERTPGVLLPGAGGAAGFGMTSPPPPTSPSRTAVPPGLSSL--PLTSVGNTGMKK 346
||| || ||||...|: ..|.:| .:.|:...|:::
Fly 122 -GPP------------------GG--------PPPPERSSQ----ENLHALQRAIDSMEEKGLQE 155
Human 347 VPKKLEEIPPASPEMAQMRKQCLDYHYQEMQALKEVFKEYLIELFFLQHFQGNMMDFLAFKKKHY 411
.|: |.::.|::...|. ||..||.::.|..:...|
Fly 156 DPR-----------------------YSQLLAMRATSKH--------QHLNGNQVNLLRTQITAY 189
Human 412 APLQAYLRQNDLDIEEEEEEEEEEEEKSEVINDEQQALAGSLVAGAGSTVETDLFKRQQAMPSTG 476
..| .|...:.:: .|||| ||
Fly 190 RLL---ARNKPISMQ------------------MQQAL--------------------QA----- 208
Human 477 MAEQSKRPRLEVGHQGVVFQHPGADAGVPLQQLMPTAQ-GGMPPTPQAAQLAGQRQSQQQYDPST 540
|:|...|...:| .|||..|.| |.:| .|.||.|. |.|||..||.
Fly 209 -AQQQPPPGPPIG-------PPGAPGGPP-----PGSQHAGQPPVPP--------QQQQQPPPSA 252
Human 541 G-PPVQNAASLHTPL-PQLPGRLPPAGVPTAALSSALQFAQQPQVVEAQTQLQIPVKTQQPNVPI 603
| ||..:......|. |.:||:......|...:........||..|.... |::.|||
Fly 253 GTPPQCSTPPASNPYGPPVPGQKMQVAPPPPHMQQGQPLPPQPPQVGGPP----PIQQQQP---- 309
Human 604 PAPPSSQLPIPPSQPAQLALHVPTPGKVQVQASQLSSLPQMVASTRLPVDPAPPCPR-PLPTSST 667
|.....|...||.:|.|..| |..|| .||..|. .....:|..|..|..| .||....
Fly 310 PQQQQQQSQPPPPEPHQHQL--PNGGK------PLSMGPS-GGQPLIPSSPMQPQVRGTLPGMPP 365
Human 668 SSLAPVSGSGPGPS-PARSSPVNRPSSATNKA----LSPVT---SRTPGVVASAPTKPQSPAQ-N 723
.|..|..|.||... |....|:.:|:..|..| |.|:| .|...:.|....:.|...: .
Fly 366 GSQVPQPGGGPQRQVPPAGMPMPKPNRITTVAKPVGLDPITLLQERENRIAARISLRMQELQRLP 430
Human 724 ATSSQD----------------------------SSQDTLTEQITLENQVHQRI-AELRKAGLWS 759
||.|:| :.:|| |||..::.:: ...::.||..
Fly 431 ATMSEDLRLQAAIELRALRVLNFQRQLRMEFVQCTRRDT-----TLETALNIKLYKRTKRQGLRE 490
Human 760 QRRLPKLQ-------EAPRPKSHWDYLLEEMQWMATDFAQERRWKVAAAKKLVRTVVRHHEEKQL 817
.|...||: |..|.:.|.::|...:| ...|..:..|...|...::.:.|:.||...:
Fly 491 ARATEKLEKQQKLEAERKRRQKHLEFLAAVLQ-HGKDLREFHRNNKAQLARMNKAVMNHHANAE- 553
Human 818 REERGKKE--EQSRLRRIAASTAR-------------------EIECFWSNIEQVVEIKLRVELE 861
||::.::| |:.|:||:.|.... :.:.:.||:.|:|:.....:::
Fly 554 REQKKEQERIEKERMRRLMAEDEEGYRKLIDQKKDKRLAFLLSQTDEYISNLTQMVKQHKDDQMK 618
Human 862 EKRKKALNLQKVSRRGKELRPKG-FDALQESSLDSGM--------SGRKRKASISLTDDE----- 912
:|.::...|.:.. |||...| :..:.|.|:.:.| :|:| ||.|:
Fly 619 KKEEEGKRLIQFK---KELLMSGEYIGIDEGSIVADMRVHVVEQCTGKK------LTGDDAPMLK 674
Human 913 --------------VDDEEETIEEEEANEGVVDHQTELSNLAKEAELPLLDLMKLYEGAFLPSSQ 963
:||||::....: ||
Fly 675 HLHRWLNMHPGWDWIDDEEDSCGSND------DH------------------------------- 702
Human 964 WPRPKPDGEDTSGEEDAD--DCPGDRESRKDLVL---IDSLFIMDQFKAAERMNIGKPNAKDIAD 1023
:||.:.:.|:.|:..| ...|:.|..|||:. ::. |:::..|: .
Fly 703 --KPKVEEQPTATEDATDKAQATGNDEDAKDLITKAKVED----DEYRTEEQ------------T 749
Human 1024 VTAVAEAILPKGSARVTTSVKFNAPSLLYGALRDYQKIGLDWLAKLYRKNLNGILADEAGLGKTV 1088
..::|..|..| |...|..::.|.|::||..||:||..||..|||||||||.|||||:
Fly 750 YYSIAHTIHEK--------VVEQASIMVNGTLKEYQIKGLEWLVSLYNNNLNGILADEMGLGKTI 806
Human 1089 QIIAFFAHLACNEGNWGPHLVVVRSCNILKWELELKRWCPGLKILSYIGSHRELKAKR--QEWAE 1151
|.|:...:|...:...||:|::|....:..|.||.::|.|.:.::||.||. :.:| |....
Fly 807 QTISLVTYLMDRKKVMGPYLIIVPLSTLPNWVLEFEKWAPAVGVVSYKGSP---QGRRLLQNQMR 868
Human 1152 PNSFHVCITSYTQFFRGLTAFTRVRWKCLVIDEMQRVKG-------MTERHWEAVFTLQSQQRLL 1209
...|:|.:|:|....:......:::||.::|||..|:|. :...|:.|.: |||
Fly 869 ATKFNVLLTTYEYVIKDKAVLAKIQWKYMIIDEGHRMKNHHCKLTQVLNTHYIAPY------RLL 927
Human 1210 LIDSPLHNTFLELWTMVHFLVPGISR------PYLSSPLRAPSEE---SQDYYHKVVIRLHRVTQ 1265
|..:||.|...|||.:::||:|.|.: .:.::|.....|: :::....::.|||:|.:
Fly 928 LTGTPLQNKLPELWALLNFLLPSIFKSCSTFEQWFNAPFATTGEKVELNEEETILIIRRLHKVLR 992
Human 1266 PFILRRTKRDVEKQLTKKYEHVLKCRLSNRQKALY-----EDVILQPGTQEALK-SGHFVNVLSI 1324
||:|||.|::||.||..|.|:::||.:|..|:.|| :.|:|..|:::... .|....:::.
Fly 993 PFLLRRLKKEVEHQLPDKVEYIIKCDMSALQRVLYKHMQSKGVLLTDGSEKGKHGKGGAKALMNT 1057
Human 1325 LVRLQRICNHPGLVEPRHPGSSYVAGPLEYPSASLILKALERDFWKEADLSMFDLIGLENKITRH 1389
:|:|:::||||
Fly 1058 IVQLRKLCNHP------------------------------------------------------ 1068
Human 1390 EAELLSKKKIPRKLMEEISTSAAPAARPAAAKLKASRLFQPVQYGQKPEGRTVAFPSTHPPRTAA 1454
Fly 1069 ----------------------------------------------------------------- 1068
Human 1455 PTTASAAPQGPLRGRPPIATFSANPEAKAAAAPFQTSQASASAPRHQPASASSTAASPAHPAKLR 1519
Fly 1069 ----------------------------------------------------------------- 1068
Human 1520 AQTTAQASTPGQPPPQPQAPSHAAGQSALPQRLVLPSQAQARLPSGEVVKIAQLASITGPQSRVA 1584
Fly 1069 ----------------------------------------------------------------- 1068
Human 1585 QPETPVTLQFQGSKFTLSHSQLRQLTAGQPLQLQGSVLQIVSAPGQPYLRAPGPVVMQTVSQAGA 1649
|...|
Fly 1069 --------------FMFQH---------------------------------------------- 1073
Human 1650 VHGALGSKPPAGGPSPAPLTPQVGVPGRVAVNALAVGEPGTASKPASPIGGPTQEEKTRLLKERL 1714
Fly 1074 ----------------------------------------------------------------- 1073
Human 1715 DQIYLVNERRCSQAPVYGRDLLRICALPSHGRVQWRGSLDGRRGKEAGPAHSYTSSSESPSELML 1779
:.|:.|.....:|
Fly 1074 -----IEEKYCDHTGGHG----------------------------------------------- 1086
Human 1780 TLCRCGESLQDVIDRVAFVIPPVVAAPPSLRVPRPPPLYSHRMRILRQGLREHAAPYFQQLRQTT 1844
||:.|...||
Fly 1087 ----------------------VVSGPDLYRV--------------------------------- 1096
Human 1845 APRLLQFPELRLVQFDSGKLEALAILLQKLKSEGRRVLILSQMILMLDILEMFLNFHYLTYVRID 1909
|||.|.|..:|.|||:...|||:..||...:.|:|.:|.:....|:|:|
Fly 1097 ----------------SGKFELLDRILPKLKATNHRVLLFCQMTQCMTIIEDYLGWRQFGYLRLD 1145
Human 1910 ENASSEQRQELMRSFN-RDRRIFCAILSTHSRTTGINLVEADTVVFYDNDLNPVMDAKAQEWCDR 1973
....:|.|.||:|.|| :...:|..:|||.:...|:||..|||||.:|:|.||..|.:||:...|
Fly 1146 GTTKAEDRGELLRKFNAKGSDVFVFLLSTRAGGLGLNLQTADTVVIFDSDWNPHQDLQAQDRAHR 1210
Human 1974 IGRCKDIHIYRLVSGNSIEEKLLKNGTKDL-IREVAAQGNDYSMAFLTQRTIQELFEVYSPMDDA 2037
||:..::.:.||::.||:||::|......| :.|...|...:... .|....|:..:.....||.
Fly 1211 IGQRNEVRVLRLMTVNSVEERILAAARYKLNMDEKVIQAGMFDQK-STGSERQQFLQTILHQDDN 1274
Human 2038 GFPVKAEEFVVLSQEPSVTETIAPKIARPFIEALKSIEYLEE-DAQKSAQEGVLGPHTDALSSDS 2101
:.|| ..|....|.|...||| :.:.||..:. ||::..::..:.|..:.|..:|
Fly 1275 ----EEEE----ENEVPDDEMINMMIAR----SEEEIEIFKRMDAERKKEDEEIHPGRERLIDES 1327
Human 2102 E---------------NMPCDEEP-----SQLEELADFMEQLTPIEKYALNYLELFHTSIEQEKE 2146
| :...||:. |:..:..|:.:.||..| :|:......|.::|
Fly 1328 ELPDWLTKDDDEVERFHYQYDEDTILGRGSRQRKEVDYTDSLTEKE-----WLKAIDDGAEFDEE 1387
Human 2147 RNSEDAVMTAVRAWEFWNLKTLQEREARLRLEQEEAELLTYTREDAYSME-------------YV 2198
...:|: ..:.|:.:.|.|:.:.:.|...|....::: .:
Fly 1388 EEEDDS--------------KRKRRKRKNRKEESDDDSLILKRRRRQNLDKRSKKQMHKIMSAVI 1438
Human 2199 YEDVDGQTEVMPLWTPPTPP--------------------------------------------- 2218
..:.||:|...|....|:..
Fly 1439 KHNQDGRTLSEPFMKLPSRQRLPDYYEIIKRPVDIKKILQRIEDCKYADLNELEKDFMQLCQNAQ 1503
Human 2219 ---QDDSDIYLDSVMCLMYEATPIPEAKLPPVYV-RKERKRHKTDPS--AAGRKKKQRHGEAVVP 2277
::.|.|||||: .|..|:| .::|.....|.: |||....:.||..
Fly 1504 IYNEEASLIYLDSI-------------ALQKVFVGARQRITAAADAAAVAAGDNTGEAHGNG--- 1552
Human 2278 PRSLFDRATPGLLKIRREGKEQKKNILLKQQVPFAKPLPTFAKPTAEPGQDNPEWLISEDWALLQ 2342
|.:...| ...:.|.|..: .|:.|...
Fly 1553 ------------------GSDNSDN------------------DDDDGGDDGSD---DEEIATTS 1578
Human 2343 AVKQLLELPLNLTIVSPAHTPNWDLVSDVVNSCSRIYRSSKQCRNR 2388
|....::|.||.::.|...||. ...|:| |......|.||.|.:
Fly 1579 AAAVKMKLKLNKSLASAPATPT-QSSSNV--SSGAATTSKKQTRRK 1621
| 
