DRSC/TRiP Functional Genomics Resources

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Protein Alignment EP400 and Iswi

DIOPT Version :10

Sequence 1:NP_056224.3 Gene:EP400 / 57634 HGNCID:11958 Length:3123 Species:Homo sapiens
Sequence 2:NP_523719.1 Gene:Iswi / 36390 FlyBaseID:FBgn0011604 Length:1027 Species:Drosophila melanogaster


Alignment Length:1366 Identity:256/1366 - (18%)
Similarity:405/1366 - (29%) Gaps:660/1366 - (48%)


- Green bases have known domain annotations that are detailed below.


Human   974 TSGEEDAD---DCPGDRESRKDLVL----IDSLFIMDQFKAAERMNIGKP-------NAKDIAD- 1023
            :|||::|:   ....||..|.|.:|    |.:.|:.:..|:..:.. |:|       ..||:|| 
  Fly    27 SSGEKEAEFDNKIEADRSRRFDFLLKQTEIFTHFMTNSAKSPTKPK-GRPKKIKDKDKEKDVADH 90

Human  1024 -----VTAVAEAILPKGSARVTTSV-KFNA-PSLL-YGALRDYQKIGLDWLAKLYRKNLNGILAD 1080
                 .....|.:|.:.||  |..: :|:| |:.: .|.:||||..||:|:..||...:||||||
  Fly    91 RHRKTEQEEDEELLAEDSA--TKEIFRFDASPAYIKSGEMRDYQIRGLNWMISLYENGINGILAD 153

Human  1081 EAGLGKTVQIIAFFAHLACNEGNWGPHLVVVRSCNILKWELELKRWCPGLKILSYIGSHRELKAK 1145
            |.|||||:|.|:...:|...:...|||:|:|....:..|..|.|:|||.|:.:..||........
  Fly   154 EMGLGKTLQTISLLGYLKHFKNQAGPHIVIVPKSTLQNWVNEFKKWCPSLRAVCLIGDQDTRNTF 218

Human  1146 RQEWAEPNSFHVCITSYTQFFRGLTAFTRVRWKCLVIDEMQRVKGMTERHWEAVFTLQSQQRLLL 1210
            .::...|..:.||:|||....|..:.|.:..|:.|||||..|:|....:..|.:...::..|||:
  Fly   219 IRDVLMPGEWDVCVTSYEMCIREKSVFKKFNWRYLVIDEAHRIKNEKSKLSEILREFKTANRLLI 283

Human  1211 IDSPLHNTFLELWTMVHFLVPGISRPYLSSPLRAPSEESQDYYH--------KVVIRLHRVTQPF 1267
            ..:||.|...|||.:::||:|.:..         .||:..::::        .::.|||.|.:||
  Fly   284 TGTPLQNNLHELWALLNFLLPDVFN---------SSEDFDEWFNTNTCLGDDALITRLHAVLKPF 339

Human  1268 ILRRTKRDVEKQLTKKYEHVLKCRLSNRQKALYEDVILQPGTQEALKSGHFVNVLSILVRLQRIC 1332
            :|||.|.:|||:|..|.|..:...||..|:..|..|:|                           
  Fly   340 LLRRLKAEVEKRLKPKKEMKIFVGLSKMQRDWYTKVLL--------------------------- 377

Human  1333 NHPGLVEPRHPGSSYVAGPLEYPSASLILKALERDFWKEADLSMFDLIGLENKITRHEAELLSKK 1397
                                                 |:.|:                       
  Fly   378 -------------------------------------KDIDV----------------------- 382

Human  1398 KIPRKLMEEISTSAAPAARPAAAKLKASRLFQPVQYGQKPEGRTVAFPSTHPPRTAAPTTASAAP 1462
                                                                             
  Fly   383 ----------------------------------------------------------------- 382

Human  1463 QGPLRGRPPIATFSANPEAKAAAAPFQTSQASASAPRHQPASASSTAASPAHPAKLRAQTTAQAS 1527
                                                                             
  Fly   383 ----------------------------------------------------------------- 382

Human  1528 TPGQPPPQPQAPSHAAGQSALPQRLVLPSQAQARLPSGEVVKIAQLASITGPQSRVAQPETPVTL 1592
                                                                             
  Fly   383 ----------------------------------------------------------------- 382

Human  1593 QFQGSKFTLSHSQLRQLTAGQPLQLQGSVLQIVSAPGQPYLRAPGPVVMQTVSQAGAVHGALGSK 1657
                                                                     |:||    
  Fly   383 ---------------------------------------------------------VNGA---- 386

Human  1658 PPAGGPSPAPLTPQVGVPGRVAVNALAVGEPGTASKPASPIGGPTQEEKTRLLKERLDQIYLVNE 1722
                              |:|                          ||.||      |..|:..
  Fly   387 ------------------GKV--------------------------EKMRL------QNILMQL 401

Human  1723 RRCSQAPVYGRDLLRICALPSHGRVQWRGSLDGRRGKEAGPAHSYTSSSESPSELMLTLCRCGES 1787
            |:|:..| |..|                       |.|.||                        
  Fly   402 RKCTNHP-YLFD-----------------------GAEPGP------------------------ 418

Human  1788 LQDVIDRVAFVIPPVVAAPPSLRVPRPPPLYSHRMRILRQGLREHAAPYFQQLRQTTAPRLLQFP 1852
                                                           ||      ||...|:   
  Fly   419 -----------------------------------------------PY------TTDTHLV--- 427

Human  1853 ELRLVQFDSGKLEALAILLQKLKSEGRRVLILSQMILMLDILEMFLNFHYLTYVRIDENASSEQR 1917
                  ::|||:..|..||.||:.:|.||||.|||..||||||.:.::....|.|:|.....|.|
  Fly   428 ------YNSGKMAILDKLLPKLQEQGSRVLIFSQMTRMLDILEDYCHWRNYNYCRLDGQTPHEDR 486

Human  1918 QELMRSFNRDRRI-FCAILSTHSRTTGINLVEADTVVFYDNDLNPVMDAKAQEWCDRIGRCKDIH 1981
            ...::.||.|... |..:|||.:...||||..||.|:.||:|.||.||.:|.:...|||:.|.:.
  Fly   487 NRQIQEFNMDNSAKFLFMLSTRAGGLGINLATADVVIIYDSDWNPQMDLQAMDRAHRIGQKKQVR 551

Human  1982 IYRLVSGNSIEEKLLKNGTKDL-IREVAAQGNDYSMAFLTQRTIQELF--------EVYSPMDDA 2037
            ::||::.:::|||:::.....| :.::..||.........|....|:.        :|:|..:. 
  Fly   552 VFRLITESTVEEKIVERAEVKLRLDKMVIQGGRLVDNRSNQLNKDEMLNIIRFGANQVFSSKET- 615

Human  2038 GFPVKAEEFVVL--------SQEPSVTETIAPKIARPFI-----EA-LKSIEYLE-EDAQKSAQE 2087
              .:..|:..|:        :::.:..:::.....|.|.     || ..|:...| ||.::..:.
  Fly   616 --DITDEDIDVILERGEAKTAEQKAALDSLGESSLRTFTMDTNGEAGTSSVYQFEGEDWREKQKL 678

Human  2088 GVLGP------------------HTDALSSDSENMPCDEEPSQLEELADFMEQLTPIEKYALNYL 2134
            ..||.                  ..:||.......|....|.:...:.||  |..|...:.|...
  Fly   679 NALGNWIEPPKRERKANYAVDAYFREALRVSEPKAPKAPRPPKQPIVQDF--QFFPPRLFELLDQ 741

Human  2135 ELFH-------------------TSIEQEKERNSEDAVMTAVRAWEFWNLKTLQEREARLRLEQE 2180
            |:::                   |.:::|::|..::|             :.|.|.|.     ||
  Fly   742 EIYYFRKTVGYKVPKNTELGSDATKVQREEQRKIDEA-------------EPLTEEEI-----QE 788

Human  2181 EAELLT--------------------YTREDAYSMEYVYEDVDGQT--EVMP----LWTPPTPPQ 2219
            :..||:                    |.|:|   ::.:.:||:|:|  ||:.    .|...|..|
  Fly   789 KENLLSQGFTAWTKRDFNQFIKANEKYGRDD---IDNIAKDVEGKTPEEVIEYNAVFWERCTELQ 850

Human  2220 D 2220
            |
  Fly   851 D 851

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EP400NP_056224.3 EP400_N 1..469 CDD:434938
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..65
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 125..154
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 212..261
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 282..359
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 509..558
PAT1 518..>780 CDD:401645
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 597..622
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 648..734
HSA 764..835 CDD:214727
HepA 849..>1338 CDD:440319 118/394 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 879..931
Interactions with RUVBL1 and RUVBL2 915..1329 118/385 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 961..988 5/16 (31%)
DEAD-like_helicase_N 1055..1271 CDD:475120 76/223 (34%)
DEAH box-like 1183..1186 2/2 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1431..1546 0/114 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1751..1771 4/19 (21%)
SF2_C_SNF 1861..1986 CDD:350180 54/125 (43%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2083..2108 5/42 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2251..2275
Interaction with ZNF42. /evidence=ECO:0000250 2488..2753
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2488..2566
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2629..2652
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2785..2833
SP1-4_N <2840..3065 CDD:425404
PRK12323 <3004..>3123 CDD:481241
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3079..3123
IswiNP_523719.1 PLN03142 46..967 CDD:215601 250/1347 (19%)
Blue background indicates that the domain is not in the aligned region.

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