DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment EP400 and Chd1

DIOPT Version :10

Sequence 1:NP_056224.3 Gene:EP400 / 57634 HGNCID:11958 Length:3123 Species:Homo sapiens
Sequence 2:NP_001245851.1 Gene:Chd1 / 33505 FlyBaseID:FBgn0250786 Length:1900 Species:Drosophila melanogaster


Alignment Length:2286 Identity:400/2286 - (17%)
Similarity:664/2286 - (29%) Gaps:959/2286 - (41%)


- Green bases have known domain annotations that are detailed below.


Human   392 FLQHFQGNMMDFLAFKKKHYAPLQAYLRQNDLDIEEEEEEEEEEEEKSEVINDEQQALAGSLVAG 456
            ||.|.:.:       |.|.:.|....|.::...|..:|:::..||     .|....:.:||....
  Fly     3 FLYHLKPD-------KSKQFDPGCRALNESANSIGSDEQDDTREE-----ANGTDHSGSGSGSGS 55

Human   457 AGSTVETDLFKRQQAMPSTGMAEQSKRPRLEVGHQGVVFQHPGADAGVPLQQLMPTAQGGMPPTP 521
            :||..::|        .|:|.:..                  |..:..|..:.:..|  |.|||.
  Fly    56 SGSDSDSD--------SSSGNSSD------------------GRSSPEPEDKSLSVA--GFPPTA 92

Human   522 QAAQLAGQR------QSQQQYDPSTGPPVQNAASLHTPLPQLPGRLPPAGVPTAALSSALQFAQQ 580
            .|||...:.      |.....|.|:|....:.|       :.|.......:..|..||:|...:|
  Fly    93 AAAQADSKTNGFTDDQEDSSSDGSSGSDSDSDA-------EGPSDQRNQSINNANTSSSLPKPEQ 150

Human   581 PQVVEAQTQLQIPVKTQQPNVPIPAPPSSQLPIPPSQPAQLALHVPTPGKVQVQASQLSSLPQMV 645
            .:..:.:|:    ...|||.....|..||......|         ||......:..:....|:..
  Fly   151 NEEEDNETE----AGQQQPASDASADESSDSSANVS---------PTSSSSSSEEEEEDYRPKRT 202

Human   646 ASTRLPVDPAPPCPRPLPTSSTSSLAPVSGSGPGPSPAR---SSPVNRPSSATNKALSPVTSRTP 707
            ...|.|           ||:     |..|...|.|...:   .|..:..|..::..:|....|.|
  Fly   203 RQARKP-----------PTA-----AEKSKKAPAPKNKKKTWDSDESDESEDSDDEVSTAQKRKP 251

Human   708 GVVASAPTKPQSPAQNAT---SSQDSSQDTLTEQITLENQVHQRIAELRKAGLWSQRRLPKLQEA 769
            ....|.....|...:...   ||:||..|          ...:|.|..||....|.:...: .||
  Fly   252 AATTSRSKLAQQQQRRRVKPFSSEDSDDD----------DASKRCATRRKGAAVSYKEASE-DEA 305

Human   770 PRPKSHWDYLLEEMQWMATDFAQERRWKVAAAKKLV------------RTVVRHHEEKQLREERG 822
            ...:...::..:|.|...|....|...|....::::            :|.:...||.......|
  Fly   306 TDSEDLLEFEYDESQAATTAATAEEEEKCETIERILAQRAGKRGCTGNQTTIYAIEENGFDPHAG 370

Human   823 KKEEQSRLRRIAASTAREIECF-----WSNIEQVVEIKLRVELEEKRKKALNLQKVSRRGKELRP 882
            ..|:|:      .....|.:..     ||.|....|.:..:                   ::::.
  Fly   371 FDEKQT------PDAETEAQFLIKWKGWSYIHNTWESEATL-------------------RDMKA 410

Human   883 KGFDALQESSLDSGMSGRKRKA---------SISLTDDEVDDEEETIEEEEANEGVV------DH 932
            ||.     ..||:.:...|.:|         .|...:.:::.:.|.::.....:.::      |.
  Fly   411 KGM-----KKLDNFIKKEKEQAYWRRYAGPEDIDYFECQLELQHELLKSYNNVDRIIAKGSKPDD 470

Human   933 QTELSNLAKEAELPLLDLMKLYEGAFLPSSQWPRPKPDGEDTSGEEDADDCP---GDRESRKDLV 994
            .|| ..|.|...||..:  ..:|.|.|...:|.|                |.   .||||.|   
  Fly   471 GTE-EYLCKWQSLPYAE--STWEDAALVLRKWQR----------------CAEQFNDRESSK--- 513

Human   995 LIDSLFIMDQFKAAERMNIGKPNAKDIADVTAVAEAILPKGSARVTTSVKF--------NAPSLL 1051
                                                ..|....||   :|:        |.|..|
  Fly   514 ------------------------------------CTPSRHCRV---IKYRPKFSRIKNQPEFL 539

Human  1052 YG--ALRDYQKIGLDWLAKLYRKNLNGILADEAGLGKTVQIIAFFAHLACNEGNWGPHLVVVRSC 1114
            ..  .|||||..||:||...:.|..:.|||||.|||||:|.|.|...|......:||.|.||...
  Fly   540 SSGLTLRDYQMDGLNWLLHSWCKENSVILADEMGLGKTIQTICFLYSLFKIHHLYGPFLCVVPLS 604

Human  1115 NILKWELELKRWCPGLKILSYIG--SHRELKAKRQEWAEPNS----FHVCITSYTQFFRGLTAFT 1173
            .:..|:.|...|.|.:.:::|:|  ..||| .::.||...:|    |:..:|:|....:......
  Fly   605 TMTAWQREFDLWAPDMNVVTYLGDIKSREL-IQQYEWQFESSKRLKFNCILTTYEIVLKDKQFLG 668

Human  1174 RVRWKCLVIDEMQRVKGMTERHWEAVFTLQSQQRLLLIDSPLHNTFLELWTMVHFLVPGISRPYL 1238
            .::|..|::||..|:|......::::....:..|||:..:||.|:..|||.::||::|.....:.
  Fly   669 TLQWAALLVDEAHRLKNDDSLLYKSLKEFDTNHRLLITGTPLQNSLKELWALLHFIMPDKFDTWE 733

Human  1239 SSPLRAPSEESQDYYHKVVIRLHRVTQPFILRRTKRDVEKQLTKKYEHVLKCRLSNRQKALYEDV 1303
            :..::..:.|.:.|     .|||:..:|:||||.|:||||.|..|.|.:|:..:::.||..|:.:
  Fly   734 NFEVQHGNAEDKGY-----TRLHQQLEPYILRRVKKDVEKSLPAKVEQILRVEMTSLQKQYYKWI 793

Human  1304 ILQPGTQEAL---KSGHFVNVLSILVRLQRICNHPGLVEPRHPGSSYVAGPLEYPSASLILKALE 1365
            :.:  ..:||   |.|.....|:|::.|::.|||..|:.|                         
  Fly   794 LTK--NFDALRKGKRGSTSTFLNIVIELKKCCNHAALIRP------------------------- 831

Human  1366 RDFWKEADLSMFDLIGLENKITRHEAELLSKKKIPRKLMEEISTSAAPAARPAAAKLKASRLFQP 1430
                     |.|:|:||:                                               
  Fly   832 ---------SEFELMGLQ----------------------------------------------- 840

Human  1431 VQYGQKPEGRTVAFPSTHPPRTAAPTTASAAPQGPLRGRPPIATFSANPEAKAAAAPFQTSQASA 1495
                                                                             
  Fly   841 ----------------------------------------------------------------- 840

Human  1496 SAPRHQPASASSTAASPAHPAKLRAQTTAQASTPGQPPPQPQAPSHAAGQSALPQRLVLPSQAQA 1560
                                                   |.:|                      
  Fly   841 ---------------------------------------QDEA---------------------- 844

Human  1561 RLPSGEVVKIAQLASITGPQSRVAQPETPVTLQFQGSKFTLSHSQLRQLTAGQPLQLQGSVLQIV 1625
                                                                             
  Fly   845 ----------------------------------------------------------------- 844

Human  1626 SAPGQPYLRAPGPVVMQTVSQAGAVHGALGSKPPAGGPSPAPLTPQVGVPGRVAVNALAVGEPGT 1690
                           :||                                               
  Fly   845 ---------------LQT----------------------------------------------- 847

Human  1691 ASKPASPIGGPTQEEKTRLLKERLDQIYLVNERRCSQAPVYGRDLLRICALPSHGRVQWRGSLDG 1755
                              |||                                            
  Fly   848 ------------------LLK-------------------------------------------- 850

Human  1756 RRGKEAGPAHSYTSSSESPSELMLTLCRCGESLQDVIDRVAFVIPPVVAAPPSLRVPRPPPLYSH 1820
                                                                             
  Fly   851 ----------------------------------------------------------------- 850

Human  1821 RMRILRQGLREHAAPYFQQLRQTTAPRLLQFPELRLVQFDSGKLEALAILLQKLKSEGRRVLILS 1885
                                                   .||||..|..||.:||..|.||||.|
  Fly   851 ---------------------------------------GSGKLVLLDKLLCRLKETGHRVLIFS 876

Human  1886 QMILMLDILEMFLNFHYLTYVRIDENASSEQRQELMRSFNRD-RRIFCAILSTHSRTTGINLVEA 1949
            ||:.|||:|..:|...:..:.|:|.:...|.|::.:..||.: .:.||.:|||.:...||||..|
  Fly   877 QMVRMLDVLADYLQKRHFPFQRLDGSIKGEMRRQALDHFNAEGSQDFCFLLSTRAGGLGINLATA 941

Human  1950 DTVVFYDNDLNPVMDAKAQEWCDRIGRCKDIHIYRLVSGNSIEEKLLKNGTKDLIRE-------- 2006
            |||:.:|:|.||..|.:||....|||:...::|||||:..|:||::::...:.::.:        
  Fly   942 DTVIIFDSDWNPQNDLQAQARAHRIGQKNQVNIYRLVTARSVEEQIVERAKQKMVLDHLVIQRMD 1006

Human  2007 ------VAAQGNDYS----------MAFLTQRTIQELFEVYSPMDDAGFPVKAEEFVVLSQEPSV 2055
                  :...||.:|          ::.:.:...:|||:.....|| ......:|.:..::    
  Fly  1007 TTGRTVLDKSGNGHSSNSNPFNKDDLSAILKFGAEELFKDEQEHDD-DLVCDIDEILRRAE---- 1066

Human  2056 TETIAPKI-ARPFIEALK--SIEYLEEDAQKSAQEGVLGPHTDALSSDSENMPCDEEPSQLEELA 2117
            |....|:: |...:.|.|  ||...||:.            :|::|...:|...:|:.|:     
  Fly  1067 TRNEDPEMPADDLLSAFKVASIAAFEEEP------------SDSVSKQDQNAAGEEDDSK----- 1114

Human  2118 DFMEQLTPIEKYALNYLELFHTSI-EQEKERNSEDAVMTAVRAWEFWNLKTL------------- 2168
            |: :.:.|         |.|..:| :||:.:..||..:...|       ||.             
  Fly  1115 DW-DDIIP---------EGFRKAIDDQERAKEMEDLYLPPRR-------KTAANQNEGKRGAGKG 1162

Human  2169 ----------------------------QEREARLRLEQE-----EAELLTYTRE------DAYS 2194
                                        ..:..|..::::     :|||..:.|.      ..:.
  Fly  1163 GKGKQQADDSGGDSDYELGSDGSGDDGRPRKRGRPTMKEKITGFTDAELRRFIRSYKKFPAPLHR 1227

Human  2195 MEYVYEDVDGQTEVMPLWTPPTPPQDDSDIYLDSVMCLMYEATPIPEAKLPPVYVRKERKRHKTD 2259
            ||.:..|.:.|.:      |....:...::..|..:..::|            :..:|.|...||
  Fly  1228 MEAIACDAELQEK------PLAELKRLGEMLHDRCVQFLHE------------HKEEESKTAATD 1274

Human  2260 --PSAAGRKKKQRHGEAVVPPRSLFDRATPGLLKIRREGKEQKKNILLKQQV-PFAKPLP----- 2316
              |.|     |||...|...            :|:.......||.:..:|:: |..:.:|     
  Fly  1275 ETPGA-----KQRRARATFS------------VKLGGVSFNAKKLLACEQELQPLNEIMPSMPEE 1322

Human  2317 ----TFAKPTAEPGQDNPEWLISEDWALLQAVKQL---------LELPLNLTIVSPAHTPNWDLV 2368
                :|...|..|..| .:|.|.||..||..:.|.         |:..|.||          |.:
  Fly  1323 RQQWSFNIKTRAPVFD-VDWGIEEDTKLLCGIYQYGIGSWEQMKLDPTLKLT----------DKI 1376

Human  2369 SDVVNSCSRIYRSSKQCRNRYENVIIPR-----EEGKSKNNRP--LRTSQIYAQDENATHTQLYT 2426
              ::|...:......|.|..|...||.:     :.|:.:..||  .|.:...|..::|:.|....
  Fly  1377 --LLNDTRKPQAKQLQTRAEYLLKIIKKNVELTKGGQRRQRRPRASRANDAKAASQSASSTIDAK 1439

Human  2427 SHFDLMKMTAGKRSPPIKPLLGMNPFQKNPKHASVLAESGINYDKPLPPIQVASLRAERIAKEKK 2491
            .| |........|:........::|...:|.:|....:.|       .|.:.|.   :..|:.||
  Fly  1440 PH-DGEDAAGDARTVAESSNSQVDPSTASPHNAPATEQHG-------DPAKKAK---KSKARSKK 1493

Human  2492 ALADQQKAQQP 2502
            ..|......:|
  Fly  1494 TSASDNNGNKP 1504

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EP400NP_056224.3 EP400_N 1..469 CDD:434938 17/76 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..65
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 125..154
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 212..261
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 282..359
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 509..558 13/54 (24%)
PAT1 518..>780 CDD:401645 55/273 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 597..622 7/24 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 648..734 19/91 (21%)
HSA 764..835 CDD:214727 13/82 (16%)
HepA 849..>1338 CDD:440319 128/525 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 879..931 8/66 (12%)
Interactions with RUVBL1 and RUVBL2 915..1329 116/441 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 961..988 4/29 (14%)
DEAD-like_helicase_N 1055..1271 CDD:475120 70/221 (32%)
DEAH box-like 1183..1186 2/2 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1431..1546 2/114 (2%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1751..1771 0/19 (0%)
SF2_C_SNF 1861..1986 CDD:350180 54/125 (43%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2083..2108 3/24 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2251..2275 9/25 (36%)
Interaction with ZNF42. /evidence=ECO:0000250 2488..2753 4/15 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2488..2566 4/15 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2629..2652
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2785..2833
SP1-4_N <2840..3065 CDD:425404
PRK12323 <3004..>3123 CDD:481241
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3079..3123
Chd1NP_001245851.1 CD1_tandem_CHD1-2_like 339..421 CDD:349313 15/111 (14%)
CD2_tandem 454..508 CDD:349306 13/72 (18%)
PLN03142 531..>1066 CDD:215601 179/1043 (17%)
CDH1_2_SANT_HL1 1205..1298 CDD:465731 22/127 (17%)
DUF4208 1521..1610 CDD:464035
Blue background indicates that the domain is not in the aligned region.

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