|
Human 2 HHGTGPQNVQHQLQRSRACP----GSEGEEQPAHPNPPPSPAAPF---APSASPSAP-------- 51
||....|..|.|.|:.::.| .|:.::..|..|..|...||| :|..||..|
Fly 357 HHQQQQQQQQTQQQQQQSAPPYMSSSKHQQAAAQLNSSPQYRAPFPQLSPQMSPRPPTMSPHPQM 421
Human 52 --------------------QSPSYQIQQLMNRSPA----------------------------- 67
|:.:.|.||:::..|:
Fly 422 SPRPVGVSPAKPPPPQQQQQQTQAQQPQQVVSNQPSQHSIQGMVGLPSPRPQPPTSGAGGAGAKG 486
Human 68 ---TGQNVNITLQSVGPVVGGNQQITLAPLPLPSP--TSPGFQFSAQPRRFE---------HGSP 118
....|| |||::..:|..:|.:.|.|:..||. ::.|.:..|.|::.: ||:.
Fly 487 PAPVAAPVN-TLQALEQMVMPSQALGLPPMDYPSAYRSAVGPRMPASPQQQQQQHQQWGAAHGAQ 550
Human 119 SYIQVTSPLSQQVQTQSPTQPSPGPGQALQNVRAGAP-----------GPGLG------------ 160
....:....:||.|.|...|....|.|..|.....|. |..:|
Fly 551 HLAALQQQQAQQQQQQVQQQQQAPPQQQQQAAMLQAQQQHHQQQLSMYGQPMGQQPQTAQQQVVP 615
Human 161 -LCSSSPTGGFVDASVLVR-------------QISLSPSSGGHFVFQDGSGLTQIAQG---AQVQ 208
:.|..|. |.||...: |.|::...|| .:.||.|..||. .|.|
Fly 616 PVTSQPPV---VAASQQQQQQQHQQQSLNDQLQHSINDIVGG----GNSSGATGGAQNQHQQQPQ 673
Human 209 LQHPGTPI----------------------------TVRERRPSQPHT----------------- 228
|....:|: :.::::|.||..
Fly 674 LAAMSSPLHQQNLPNMHHLIQPTMETTQPTQQQQQTSQQQQQPQQPQATLTSPHHQQMQHQSPIH 738
Human 229 QSGGTIHH--------------------LGPQSPAAAGGAGLQPLASPSHITTANLPPQISSIIQ 273
|...:.|| ||...|||: |...||:| :||.:.
Fly 739 QQQQSPHHQQHLPSYNQSQQQFDPFANILGDNQPAAS-----QQTMSPAH---------VSSPVP 789
Human 274 GQLVQQQQVLQGPP---LPRPLGFERTPGVLLPGAGGAAGFGMTSPPPPTSPS--------RTAV 327
.|:.|||...|..| :|: .:...|..|.. .|....|::|| .||.
Fly 790 AQMQQQQHQTQQQPSQQVPQ----SQQQQVSQPQQ-------QTQQQQPSTPSHHLSSILNETAN 843
Human 328 PPGLSSLPL----------TSVGNTGMKKVPKKLEE------IPPASPEMAQMRKQCLDYHYQEM 376
....|:|.: .|..|:.:...|..:.: |..:|....|:.....:.|....
Fly 844 SNDSSTLAVAANDSNNSSSNSSTNSIVNNQPTSVHDSNSQSSINSSSNNQQQLLMDNTNSHGGNS 908
Human 377 QALKEVFKEYLIELFFLQHFQGNMMDFLAFKKKHYAPLQAYLRQNDLDIEEEEEEEEEEEE---- 437
::.:....: :.||.......|.....|......:...|.|..|......|.|:.:.|.|
Fly 909 ESAQNAGVD--VGLFDNNSMSSNSAAVAAVASNAASAAAALLDSNSQSSNAEFEKNQSEGEGLGV 971
Human 438 -------KSEVINDEQQ-------ALAGSLVAGAGSTVETDLFKR-----QQAMPSTGMAEQSK- 482
::::..||.. .|:..| .|::.||.:: :|......:.:.||
Fly 972 VEGVIANETDLPQDENSVSKTQDITLSTEL-----PTIQDDLQEKPTAEMEQTQLGQSLGDLSKS 1031
Human 483 ---RPRL--EVGHQ------GVVFQHPGADAGVPL----QQLMPTAQGGMPPTPQAAQLAGQRQS 532
.|:. |.|.. ||. |.||..:|: ||.||.. |||..|.|.....|.|.
Fly 1032 LLEEPKTVEESGEDKSQSAPGVA---PPADPIIPVTQPPQQQMPPI--GMPMHPIAPGYEAQAQG 1091
Human 533 QQQYDPSTGPPVQNAASLHTPLPQLPGR--------------LPP-------------------- 563
|....|.. ||...|..::.|.|.|..: :||
Fly 1092 QGHMPPMM-PPYGGAPGMYPPYPMLHQQEIAALQQQIQELYCMPPGHELQHQDKLMRMQERLNLL 1155
Human 564 ---------AGVPTAALSSAL--------------QFAQQPQV---------------------- 583
||.|...|...: |..:.|||
Fly 1156 TQHEVNDQCAGGPQCLLFQNVPPMYGPPGNPLLNQQMVESPQVSSTTGRGRGKSANKPRKPRAKK 1220
Human 584 -VEAQTQLQIPVKTQQPNVPIPAP------PSSQLPIPPSQPAQLALHVPTPGKVQVQ------A 635
.:||...|..:.....||.:.|. |::|||:......|.|......|.::.. :
Fly 1221 GEKAQVGQQQDLMDISGNVAMGAANAVSSIPTTQLPVSEDCVTQGAGDTSVVGMLEYSEGMGDLS 1285
Human 636 SQLSSLPQMVAST------------RLPVDPAPPCPR-----------PLPTSSTSS-------- 669
..:.|..::..|| |.|.||..| || |...:||.:
Fly 1286 QDVHSANELDTSTDGSGKKKKPRKPRTPKDPNKP-PRDRTPKAKKPKDPNDPNSTETPAAVKKRA 1349
Human 670 ----------------------------LAPVSGSGPGPSPARSS--------------PVNR-- 690
|.|.:||..|.:...|. ||::
Fly 1350 GASKRRKQYGEDGAEQTGEGSEVEDNKPLVPKAGSADGEAETTSGGTGVDGESPDYDDIPVSKIP 1414
Human 691 --------------------PSSATNKALSP---------------------------------- 701
|.||.:.|.:|
Fly 1415 RGSNEDEKEAEAGDETVDSVPDSAGDPASTPSRRDRKRSTARSRRNANSEEGGSARKNRGSLSAK 1479
Human 702 --------------------VTSRTPG-------------------------------------- 708
...|||.
Fly 1480 ALKKRRNRGRIVPESDGEDDTLDRTPPPSPPPDSEMDSNKRRSSRNTQRKKYIDDVMLRFSDDEN 1544
Human 709 --VVASAPTKPQSPAQNATSSQ----------------DSSQDT--------LTEQITLE----- 742
:|||...|.:.|:.||::|. |::|:. |.|...||
Fly 1545 SLLVASPVKKDKKPSANASNSNAGSDVEKTEPQSGAEGDAAQEVGEEKSNLPLDESSQLEASSST 1609
Human 743 -----------------------NQVH-------QRIAELRKAGLWSQRRL----PKLQEAPRPK 773
|.|: ..:.:|..|....:|.| || ::||.||
Fly 1610 SAVAEKERQISTDAANAAMSSKPNYVYINTGDEDSMVVQLVLAMRMGKRELILDKPK-EKAPEPK 1673
Human 774 SHWDYLLEEMQWMATDFAQERRWKVAAAKKLVRTVVRHHEEKQLREERGKKE----EQSRLRRIA 834
. |....|:....||..: .:||...|...||: |:::|.
Fly 1674 Q--DEEKSELDEATTDKPE-------------------GDEKFKTEGESKKDLTDSEETKLE--- 1714
Human 835 ASTAREIECFWSNIEQVVEIKLRVELEEKRKKALNL-QKVSRRGKELRPKGFDALQESSL----D 894
|:|.|:: |..|...:...:.:.:.|.|..:.: .:|.:..||.:|: ::|.. :
Fly 1715 -SSAMEVD---SKEESEPDDSKKSDEDNKDKDKMEVDDEVGKSDKESKPE-----EQSETVKTEE 1770
Human 895 SGMSGRKRKASISLTDDEVDDEEETIEEEEANEGVVDHQTELSNLAKEAELPLLDLMKLYEGAFL 959
:..:..:.|:|..||.|...:.|..:|:.|.:|...|.|:.:|.. ||:..
Fly 1771 NSKAIEEDKSSTVLTADHAKEPETVLEKMEVDEKANDDQSAVSKA---------------EGSDE 1820
Human 960 PSSQWPRPK--------------------PDGEDTSGEEDADDCPGDRESRKDLVLID--SLFI- 1001
.|:....|: .:||::..:|:.:....|.|::.:.|.|| ..|:
Fly 1821 KSTDDSNPEEATTEKNKESLEIEGEKERVKEGEESVKKENDEKTEADMENKPEPVFIDVEEYFVK 1885
Human 1002 -----------------------------MDQFKAAERMNI-----GKPNAKDIADVTAVAE--- 1029
..|.|.::::|| .:|..:|..:|..|.:
Fly 1886 YRNFSYLHCEWRTEEELLKGDRRVAAKIRRFQQKQSQQLNIFENIEDEPFNQDFTEVDRVLDMSV 1950
Human 1030 -----------------AILP-----------KGSARVTTSVKFNA--------------PSL-- 1050
..|| ..:.::...::||. |.|
Fly 1951 HTDETSGETTKHYLVKWKSLPYEDCTWELEEDVDNDKIEQYLRFNKIPQRSEWKSKKRPHPELWK 2015
Human 1051 ------LY---GALRDYQKIGLDWLAKLYRKNLNGILADEAGLGKTVQIIAFFAHLACNEGNWGP 1106
:| .:||.||..||:||...:....|.|||||.|||||:|.:. |.|.....|..||
Fly 2016 KLEKTPVYKGGNSLRPYQLEGLNWLKFSWYNTHNCILADEMGLGKTIQSLT-FVHSVYEYGIRGP 2079
Human 1107 HLVVVRSCNILKWELELKRWCPGLKILSYIGSHRELKAKRQEW------------AEPNSFHVCI 1159
.||:.....|..|:.|.:.| ..:.::.|.||... |...|:: .||..|:|.|
Fly 2080 FLVIAPLSTIPNWQREFEGW-TDMNVVVYHGSVTS-KQMIQDYEYYYKTESGKVLKEPIKFNVLI 2142
Human 1160 TSYTQF---FRGLTAFTRVRWKCLVIDEMQRVKGMTERHWEAVFTLQSQQRLLLIDSPLHNTFLE 1221
|::... :..|.|| .|:..||||..|:|....:..|.:..|..:.|:||..:||.|...|
Fly 2143 TTFEMIVTDYMDLKAF---NWRLCVIDEAHRLKNRNCKLLEGLRQLNLEHRVLLSGTPLQNNISE 2204
Human 1222 LWTMVHFLVPGISRPYLSSPLRAPSEESQDYYHKVVIRLHRVTQPFILRRTKRDVEKQLTKKYEH 1286
|:::::||.|. ..||.....||.......:.|.:|..:.:|.:|||.|.||||.|..|.|.
Fly 2205 LFSLLNFLEPS----QFSSQEEFMSEFGSLRTEEEVNKLQALLKPMMLRRLKDDVEKSLAPKEET 2265
Human 1287 VLKCRLSNRQKALYEDVI------LQPGTQEALKSGHFVNVLSILVRLQRICNHPGLVEPRHPGS 1345
:::..|:|.||..|..:: |:.|| .|.:..|:::.::.|::.|.||.|
Fly 2266 IIEVELTNIQKKYYRGILEQNFSFLKKGT----TSANIPNLMNTMMELRKCCIHPYL-------- 2318
Human 1346 SYVAGPLEYPSASLILKALERDFWKEADLSMFDLIGLENKITRHEAELLSKKKIPRKLMEEISTS 1410
|.|.|.:|
Fly 2319 ---------------------------------LNGAEEQI------------------------ 2326
Human 1411 AAPAARPAAAKLKASRLFQPVQYGQKPEGRTVAFPSTHPPRTAAPTTASAAPQGPLRGRPPIATF 1475
||. |.|.|
Fly 2327 ---------------------QYD---------FKSQH--------------------------- 2334
Human 1476 SANPEAKAAAAPFQTSQASASAPRHQPASASSTAASPAHPAKLRAQTTAQASTPGQPPPQPQAPS 1540
Fly 2335 ----------------------------------------------------------------- 2334
Human 1541 HAAGQSALPQRLVLPSQAQARLPSGEVVKIAQLASITGPQSRVAQPETPVTLQFQGSKFTLSHSQ 1605
|| .||:
Fly 2335 ------------------------GE------------------DPES----------------- 2340
Human 1606 LRQLTAGQPLQLQGSVLQIVSAPGQPYLRAPGPVVMQTVSQAGAVHGALGSKPPAGGPSPAPLTP 1670
Fly 2341 ----------------------------------------------------------------- 2340
Human 1671 QVGVPGRVAVNALAVGEPGTASKPASPIGGPTQEEKTRLLKERLDQIYLVNERRCSQAPVYGRDL 1735
|.::|
Fly 2341 ------------------------------------------------------------YYKNL 2345
Human 1736 LRICALPSHGRVQWRGSLDGRRGKEAGPAHSYTSSSESPSELMLTLCRCGESLQDVIDRVAFVIP 1800
:
Fly 2346 I---------------------------------------------------------------- 2346
Human 1801 PVVAAPPSLRVPRPPPLYSHRMRILRQGLREHAAPYFQQLRQTTAPRLLQFPELRLVQFDSGKLE 1865
..:||:.
Fly 2347 ----------------------------------------------------------LSAGKMV 2353
Human 1866 ALAILLQKLKSEGRRVLILSQMILMLDILEMFLNFHYLTYVRIDENASSEQRQELMRSFNR---D 1927
.:..||.|||:.|.||||.|||:..|||||.:|.:....:.|||.......|||.:..::: |
Fly 2354 LIDKLLPKLKANGHRVLIFSQMVRCLDILEDYLVYRKYPFERIDGRIRGNLRQEAIDRYSKPGSD 2418
Human 1928 RRIFCAILSTHSRTTGINLVEADTVVFYDNDLNPVMDAKAQEWCDRIGRCKDIHIYRLVSGNSIE 1992
|.:| :|.|.:...||||..||||:.||:|.||..|.:||..|.|||:.|.:.||||:..|:.|
Fly 2419 RFVF--LLCTKAGGLGINLTAADTVIIYDSDWNPQNDLQAQARCHRIGQRKMVKIYRLLCRNTYE 2481
Human 1993 EKLLKNGT------KDLIREVAAQGN-DYSMAFLTQRTIQELFE--VYSPM---DDAGFPVKAEE 2045
.::....: |.:::.:..||: |.:...|:::.|::|.: .|..: |:||
Fly 2482 REMFDKASMKLGLDKAVLQSMNTQGSKDGNNKQLSKKEIEDLLKKGAYGAVMDDDNAG------- 2539
Human 2046 FVVLSQEPSVTETIAPKIARPFIEALKSIEYLEEDAQKSAQEGVLGPHTDALSSDSENMPCDEEP 2110
.::.|||. :.:|...|..::.:||......:.
Fly 2540 ----------------------------DKFCEEDI-----DSILKRRTQVITMESEKGSTFSKA 2571
Human 2111 SQLEELADFMEQLTPIEKYALNYLELFHTSIEQEKERNSEDAVMTAVRAWEFWNLKTLQEREARL 2175
| |..| .|..|..:.....|..|..|...:.:|
Fly 2572 S-------------------------FAAS------GNRSDITIDDPDFWTKWAKKVDIDPDA-- 2603
Human 2176 RLEQEEAE--LLTYTREDAYSMEYVYEDVDGQTEVMPLWTPPTPPQDDSDIYLDSVMCLMYEATP 2238
.|::|.| :|:..|.......|.:|| ||.| .......::||
Fly 2604 -CERDETEDLVLSEPRRRTQIKRYGHED------VMEL-NSEESSNENSD--------------- 2645
Human 2239 IPEAKLPPVYVRKERKRHKTDPSAAGRKKKQRHGEAVVPPRSLFDRATPGLLKIRREGKEQKKNI 2303
:...:.:|..|::.|.| :.:::.|.....||.....|..||.:| :.|...|...
Fly 2646 ----EEGGIGLRSRRRKEKRD------RAREKKGNDEYIPRERDALAALGLEEI-QYGNWAKSEC 2699
Human 2304 LLKQQVPFAKPLPTFAKPTAEPGQDNPEWLISEDWALLQAVKQLLELPLNLTIVSPAHTPNW--- 2365
. ..|.| |:|..|. ...:|||| ......|
Fly 2700 F-----------------KVEKG------LLSFGWG---RWSELLEL--------GQFKRGWRDV 2730
Human 2366 ---DLVSDVVNSCSRIYRSSKQCRNRYENVIIPREEGKSKNNRPLRTSQIYAQDENATHTQLYTS 2427
|....::..|.::|:..::.:....::|.|.|:|: .|..::|.:..|
Fly 2731 DVEDCARIILLYCLQVYKGDEKIKTFIWDLITPTEDGE---------VQKISRDHSGLH------ 2780
Human 2428 HFDLM----------KMTAGKRSPPIKPLLGMNPFQKNPKHASVLAESGINYDKPLPPIQVASLR 2482
:|: |.:.|..:|......|.|.....|.|.|...:.. ||....|..:::.
Fly 2781 --NLVPRGRNGGKSNKESTGVSTPAPGSASGSNSGNTTPAHKSSALDGS---DKDSGGINASAVA 2840
Human 2483 A--------ERIAKEKKALAD-------------------------------------QQKAQQP 2502
| ...:|::|..|| ||.....
Fly 2841 AAVTSIHDPNHWSKKEKYDADAYLEGAYKKHLGRHANKVLLRVRMLYYIQHEVIGDFVQQIKDNT 2905
Human 2503 AVAQPPPPQPQPPPPPQQPP-------------------------------PPLPQPQAAGSQPP 2536
.:::.| .:|||.|.|.| |.|......|:...
Fly 2906 PISELP---IRPPPTPDQVPSSWWNPICCDKSLLVGTYKHGCEMYRQMRADPNLCFVTHVGAGAA 2967
Human 2537 AGPPAVQPQPQPQPQTQPQPVQAPAKAQPAITT---GGSAAVLAGTIKTSV--------TGTSMP 2590
....||...|..:.....:............|| ..|..:..|..|.|: :|.|..
Fly 2968 GDDLAVTSLPINEDDANSKHDDGDEVDDDGTTTTKDSDSTKLTGGDNKDSLLDPERPSSSGKSSS 3032
Human 2591 TGAVSGNVIVNTIAGVPAATFQSINKRLASPVAPGALTTPGGSAPAQVVHTQPPPRAVGSPATAT 2655
..|..|| ..|.:...|.|....:.: |.|.|| .|......| |.....:||
Fly 3033 ENASGGN--DKTESENDATTVSESSYK--SEVLPG----KGSDLDVSV--------AQQDALSAT 3081
Human 2656 PDLVSMATTQGVRAVTSVTASAVVTTNLTPVQTPARSLVPQV---SQATGVQLPGKTITPAHFQL 2717
|:|.:.:..:..:....|:||... .||.|..|:. :|.|||| |.......:
Fly 3082 PELANTSDPKMNKNDAQVSASVSC--------DPADSSSPEAAGKAQGTGVQ----TGDAGELDI 3134
Human 2718 LRQQQQQQQQQQQQQQQQQQQQQQQQQQQQQTTTTSQVQVPQIQGQAQSPAQIKAVGKLTPEHLI 2782
:.:::..::.|..|....|.::.:..|.|..:|.|..|
Fly 3135 ----------------------ESEKKDNEKETKESTGDAPAVEAKKDSAAIARAEGDKT----- 3172
Human 2783 KMQKQKLQMPPQPPPPQAQSAPPQPTAQVQVQTSQPPQQQSPQLTTVTAPRPGALLTGTTVANLQ 2847
:|.....|..:...|: .||:| ..||..|..
Fly 3173 ------------------ESCTNNATTNISTTTT---------TTTIT--------NTTTTTNNP 3202
Human 2848 VARLTRVPTSQLQAQGQMQTQAPQPAQVALAKPP-VVSVPAAVVSSPGVTTLPMNVAGISVAIGQ 2911
.::......:...|.........:...||.:.|| |.:|..|....|.:..|...:..:..|.
Fly 3203 SSKAANSNNTTDHANSNSHLGLDEEESVAGSYPPTVAAVEDATTMWPSMQDLNTRLRRVITAY-- 3265
Human 2912 PQKAAGQTVVAQPVHMQQLLKLKQQAVQQQKAIQPQAAQGPAAVQQKITAQQITTPGAQQKVAYA 2976
|..:.::.|||:|:| |:.|...:||
Fly 3266 -----------QRNYKKEELKLQQKA--------------------KLQALVSSTP--------- 3290
Human 2977 AQPALKTQFLTTPISQAQKLAGAQQVQTQIQVAK------LPQVVQQQTPVASIQQVASASQQAS 3035
.....|||. .|.:|.|:|... :....|......|:|.:.. ||.||
Fly 3291 -----PLSVPTTPT--------LQSMQMQLQSGSGSGGSGIGSSAQHDASGRSLQALMQ-SQGAS 3341
Human 3036 PQTVALTQATAAG------QQVQM-----IPAVTATAQV 3063
....|...|::|| .||.| :||:...|.:
Fly 3342 TSAAAAAAASSAGGSCSGSGQVGMGGAGVMPAMPTAADI 3380
| 
