DRSC/TRiP Functional Genomics Resources

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Protein Alignment LRCH2 and scrib

DIOPT Version :10

Sequence 1:NP_065922.3 Gene:LRCH2 / 57631 HGNCID:29292 Length:765 Species:Homo sapiens
Sequence 2:NP_001163746.1 Gene:scrib / 44448 FlyBaseID:FBgn0263289 Length:2585 Species:Drosophila melanogaster


Alignment Length:768 Identity:164/768 - (21%)
Similarity:254/768 - (33%) Gaps:273/768 - (35%)


- Green bases have known domain annotations that are detailed below.


Human    69 GSLQPQHTVRSLDRALEEAGSSGILSLSGRKLRDFPGSGYDLTDTTQADLSRN------------ 121
            |.|.|.  :::.:..:|       |.:|...:.|.|.....|.....||.|.|            
  Fly    73 GRLPPD--IQNFENLVE-------LDVSRNDIPDIPDDIKHLQSLQVADFSSNPIPKLPSGFSQL 128

Human   122 -----------RFTEIPSDVWLFAPLETLNLYHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPKY 175
                       ..|.:|:|......||:|.|..|.:|.:||.|..|..|..|::..|.:..||.|
  Fly   129 KNLTVLGLNDMSLTTLPADFGSLTQLESLELRENLLKHLPETISQLTKLKRLDLGDNEIEDLPPY 193

Human   176 LFDLP-LKVLVVSNNKLVSIPEEIGKLKDLMELDISCNEIQVLPQQMGKLHSLRELNIRRNNLHV 239
            |..|| |..|.:.:|:|..:|.|:|.|..|..||:|.|.::.||.::..|.||.:|::.:|.|..
  Fly   194 LGYLPGLHELWLDHNQLQRLPPELGLLTKLTYLDVSENRLEELPNEISGLVSLTDLDLAQNLLEA 258

Human   240 LPD---ELGDLPLVKLDFSCNKVTEIPVCYRKLHHLQVIILDNNPLQVPPAQICLKGKV------ 295
            |||   :|..|.::|||  .|::..:........::|.:||..|.|...||.|....|:      
  Fly   259 LPDGIAKLSRLTILKLD--QNRLQRLNDTLGNCENMQELILTENFLSELPASIGQMTKLNNLNVD 321

Human   296 -HIFKY--LNIQACC----------RMDKKPDSLD-----------------LPS---------- 320
             :..:|  |.|..|.          ::.|.|..|.                 ||.          
  Fly   322 RNALEYLPLEIGQCANLGVLSLRDNKLKKLPPELGNCTVLHVLDVSGNQLLYLPYSLVNLQLKAV 386

Human   321 -LSKRMPSQPLTDSMED-------------FYPNKNHGP-----DSGIGSDNGEKRLSTTEPSDD 366
             ||:.. ||||.....|             ..|.:.:.|     |....|:..|:|    |||  
  Fly   387 WLSENQ-SQPLLTFQPDTDAETGEQVLSCYLLPQQEYQPITPARDLESDSEPFEER----EPS-- 444

Human   367 DTVSLHSQVSESNRE-----------------------QTSRNDSH------------------- 389
            .||...|:.:...:|                       :.|||:.|                   
  Fly   445 RTVVKFSEEATQEKETPFVRQNTPHPKDLKAKAQKLKVERSRNEEHANLVTLPEENGTKLAETPT 509

Human   390 -------------------IIGSKTDSQKDQEVYDFVDPNTEDVA-VPEQGN------------- 421
                               |:|.   :.|...|...|.|.|..|| ...||.             
  Fly   510 ETRTIANNHQQQPHPVQQPIVGV---NSKQPVVVGVVTPTTTTVAPTGVQGGSEGASSTANNVKA 571

Human   422 ---AHIGSFVSFFKGKEKCSEKSRKNEELGDEKRLEKEQLLAEEEDDD----------------- 466
               |.:....:...|.::..:...:.:|...::|:..:   .|.||||                 
  Fly   572 ATAAVVAELAATVGGSDEVQDDDEQEDEFESDRRVGFQ---VEGEDDDFYKRPPKLHRRDTPHHL 633

Human   467 ----LKEVTDLRK---IAAQLLQQEQKNRILNHSTSVMRNKPKQTVECEKSVSADEVNSPLSPLT 524
                ::.:||.:.   :|..|..||:.:....||.|                  .:|.||:.  .
  Fly   634 KNKRVQHLTDKQASEILANALASQERNDTTPQHSLS------------------GKVTSPIE--E 678

Human   525 WQPLENQKDQIDEQPWPESHPIIWQSEERRRSKQIRKEYFKYKSMRKSSSGNENDEQDSDNANMS 589
            .:.||.:::|..:|   :.||                    :.|.....|..:..|..:|..|:.
  Fly   679 EEQLEVEQEQQQQQ---QQHP--------------------FDSSLSPISAGKTAEASTDPDNLD 720

Human   590 TQSPVSSEEY----DRT-DGFSHSPFGLKPRSAFSR-------SSRQEYGAAD 630
            ..:.:..|:|    :|| .|...|..|.|..:.|..       |...|.|.||
  Fly   721 GVTELRLEQYEIHIERTAAGLGLSIAGGKGSTPFKGDDDGIFISRVTEAGPAD 773

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRCH2NP_065922.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..39
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 55..76 3/6 (50%)
LRR 1 89..110 4/20 (20%)
leucine-rich repeat 92..112 CDD:275380 5/19 (26%)
LRR <108..>282 CDD:443914 61/200 (31%)
LRR 2 112..133 7/43 (16%)
leucine-rich repeat 113..135 CDD:275380 7/44 (16%)
LRR 3 135..156 9/20 (45%)
leucine-rich repeat 136..158 CDD:275380 10/21 (48%)
LRR 4 158..179 7/20 (35%)
leucine-rich repeat 159..174 CDD:275380 4/14 (29%)
LRR 5 180..201 8/21 (38%)
leucine-rich repeat 181..203 CDD:275380 8/21 (38%)
LRR 6 203..224 7/20 (35%)
leucine-rich repeat 204..226 CDD:275380 8/21 (38%)
LRR 7 226..248 9/24 (38%)
leucine-rich repeat 227..247 CDD:275380 8/22 (36%)
leucine-rich repeat 249..271 CDD:275380 4/21 (19%)
LRR 8 249..269 4/19 (21%)
LRR 9 271..292 8/20 (40%)
leucine-rich repeat 272..290 CDD:275380 7/17 (41%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 316..401 30/191 (16%)
DUF5401 <434..539 CDD:375164 22/128 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 498..552 9/53 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 565..628 16/74 (22%)
CH_LRCH2 643..753 CDD:409120
scribNP_001163746.1 leucine-rich repeat 18..38 CDD:275380
LRR_8 37..95 CDD:404697 6/30 (20%)
leucine-rich repeat 39..61 CDD:275380
leucine-rich repeat 62..84 CDD:275380 3/12 (25%)
LRR 67..408 CDD:443914 90/346 (26%)
leucine-rich repeat 85..107 CDD:275380 6/28 (21%)
leucine-rich repeat 108..130 CDD:275380 4/21 (19%)
leucine-rich repeat 131..153 CDD:275380 3/21 (14%)
leucine-rich repeat 154..176 CDD:275380 10/21 (48%)
leucine-rich repeat 177..199 CDD:275380 8/21 (38%)
leucine-rich repeat 200..222 CDD:275380 8/21 (38%)
leucine-rich repeat 223..245 CDD:275380 8/21 (38%)
leucine-rich repeat 269..289 CDD:275380 5/21 (24%)
leucine-rich repeat 292..314 CDD:275380 8/21 (38%)
leucine-rich repeat 315..337 CDD:275380 4/21 (19%)
leucine-rich repeat 361..382 CDD:275380 2/20 (10%)
PDZ1_Scribble-like 730..816 CDD:467188 13/44 (30%)
PDZ2_Scribble-like 927..1019 CDD:467187
PDZ3_Scribble-like 1238..1327 CDD:467186
PDZ4_Scribble-like 1331..1428 CDD:467185
Blue background indicates that the domain is not in the aligned region.

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