DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LRCH2 and Lrch

DIOPT Version :10

Sequence 1:NP_065922.3 Gene:LRCH2 / 57631 HGNCID:29292 Length:765 Species:Homo sapiens
Sequence 2:NP_609834.2 Gene:Lrch / 35041 FlyBaseID:FBgn0032633 Length:1135 Species:Drosophila melanogaster


Alignment Length:823 Identity:274/823 - (33%)
Similarity:391/823 - (47%) Gaps:186/823 - (22%)


- Green bases have known domain annotations that are detailed below.


Human     7 GGGNSGGGGCGGGGSS-GGCGTAGGGGGGAGGGGGGGGGTLVVPIPVPTLFGQPFPNGPPWNPGS 70
            |.|::.|...|.|.:| .|.||  |.|.|.|..|.....|                     :...
  Fly    15 GVGSAAGSAIGSGSASLPGSGT--GSGSGIGHAGNTSSST---------------------SSAL 56

Human    71 LQPQHTVRSLDRALEEAGSSGILSLSGRKLRDFP--GSGYDLTDTTQADLSRNRFTEIPSDVWLF 133
            |......|||:|.||||..||.|.|:.|||:|||  |:.|.||||..||||||||.|:|.:|..|
  Fly    57 LSHSQLTRSLERILEEAHFSGELILTNRKLKDFPRTGTKYSLTDTVIADLSRNRFAELPEEVTTF 121

Human   134 APLETLNLYHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLFDLPLKVLVVSNNKLVSIPEEI 198
            |.||||.||||.|::|||::|.|..||||::..|.||:||:.:..|||:||:||||:|.|:|:|:
  Fly   122 AFLETLLLYHNTIRSIPESVKQLSSLTYLDLRSNQLSSLPREICFLPLQVLLVSNNRLTSLPDEL 186

Human   199 GKL-KDLMELDISCNEIQVLPQQMGKLHSLRELNIRRNNLHVLPDELGDLPLVKLDFSCNKVTEI 262
            |:| :.|.:||.|.|::..||.::|:|.|||.|::|.|:|..||.||..|.|:.||.|.||:..:
  Fly   187 GRLDQTLTDLDASYNQLANLPARLGELRSLRSLSLRSNHLLYLPRELTCLSLISLDVSNNKIASL 251

Human   263 PVCYRKLHHLQVIILDNNPLQVPPAQICLKGKVHIFKYLNIQACCRMDKKPD----SLDLPSLSK 323
            |:..|.:..|..:.|:||||..|||.:|::|.||:||:|..||  ..|:|..    :.|..:..:
  Fly   252 PLEIRHMSTLVELQLENNPLTSPPASLCMRGLVHVFKFLETQA--TKDEKGSRSGGNYDGYTTLR 314

Human   324 RMP---------SQPLTDSMEDFYPNKNHGPDSGIGSDNG-EKRLSTTEPSDDDTVS-------- 370
            |.|         ....|.|..:   .:.|..|||..:.:| :||.|...|:...|.|        
  Fly   315 RAPRHNSSGNVLEASTTGSTNN---QRRHQVDSGYNTSDGLDKRWSHDAPTKSKTDSPLHCVSNS 376

Human   371 ------------LHSQVSESNREQTSRND--------------------SHIIGSKTDSQKDQEV 403
                        :|||....:...||...                    :|...|...|..||: 
  Fly   377 TAATLPRTLPSAVHSQADLMDASLTSSTSTIVDESLTLSPTASPCKLSYAHSNSSSNGSSPDQD- 440

Human   404 YDFVDPNTEDVAVPEQ----------GNAHIGSFVSFFKGKEKCSEKSRKNEELGDEKRLEKEQL 458
                    :|:.:..|          ....:|:..::.:.||  :.|.::|:|:...|:......
  Fly   441 --------DDIMLDHQERTVHHANGRSGKGLGNIQTYKEYKE--ALKQQRNQEISVYKQKHPNAN 495

Human   459 LAEEEDDDLKEVTDLRKIAAQLLQQEQKNRILNHST------SVMRNKPKQTVE------CEKSV 511
            .:..:|:||               ......|.|.|:      |:|:....|...      .....
  Fly   496 HSPNDDEDL---------------SPSPPSISNGSSSNTLPKSIMKQNSNQIGHNGNGNGSANGN 545

Human   512 SADEVNSPLSPLTWQPLENQK---DQIDEQPWPESHPIIWQSEERRRSKQIRKEYFKYKSMRKSS 573
            ..|:|..|..|:       ||   .:|.|.. |.|     .|:.|..:......|.|.:|..|:.
  Fly   546 GVDDVVIPKKPI-------QKVIPSRITEIK-PAS-----TSDIRSANSSDCLGYVKPQSPMKNG 597

Human   574 SGNENDEQDSDNANMST----------QSPVSSE------EYDRTDGFSHSPFGLKPRSAFSRSS 622
            :...|   .|:...:.|          :|||||.      :..|:..::|               
  Fly   598 TSKFN---TSNGGGVQTTVGIVSSTTIKSPVSSTTKLGTVKTHRSVTWNH--------------- 644

Human   623 RQEYGAADPGFTMRRKMEHLREEREQIRQLRNNLESRLKVILPDDIGAALMDGVVLCHLANHIRP 687
              :..|....|||||:.:..|||.|.:.|||..:|:|||:.||.||.:||.|||:||||||::||
  Fly   645 --DIPAEKLSFTMRREFDRQREETELMSQLRTIIETRLKMTLPVDIASALTDGVILCHLANYVRP 707

Human   688 RSVASIHVPSPAVPKLSMAKCRRNVENFLDACKKLGVSQERLC 730
            |||||||||||.|.||:||:|||||:|||:||:::||.:|.:|
  Fly   708 RSVASIHVPSPGVNKLTMARCRRNVDNFLEACRRIGVDEELIC 750

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRCH2NP_065922.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..39 13/32 (41%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 55..76 1/20 (5%)
LRR 1 89..110 12/22 (55%)
leucine-rich repeat 92..112 CDD:275380 11/21 (52%)
LRR <108..>282 CDD:443914 89/174 (51%)
LRR 2 112..133 13/20 (65%)
leucine-rich repeat 113..135 CDD:275380 13/21 (62%)
LRR 3 135..156 13/20 (65%)
leucine-rich repeat 136..158 CDD:275380 14/21 (67%)
LRR 4 158..179 9/20 (45%)
leucine-rich repeat 159..174 CDD:275380 8/14 (57%)
LRR 5 180..201 13/20 (65%)
leucine-rich repeat 181..203 CDD:275380 13/22 (59%)
LRR 6 203..224 8/20 (40%)
leucine-rich repeat 204..226 CDD:275380 9/21 (43%)
LRR 7 226..248 11/21 (52%)
leucine-rich repeat 227..247 CDD:275380 10/19 (53%)
leucine-rich repeat 249..271 CDD:275380 8/21 (38%)
LRR 8 249..269 8/19 (42%)
LRR 9 271..292 10/20 (50%)
leucine-rich repeat 272..290 CDD:275380 9/17 (53%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 316..401 24/134 (18%)
DUF5401 <434..539 CDD:375164 23/119 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 498..552 12/62 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 565..628 13/78 (17%)
CH_LRCH2 643..753 CDD:409120 58/88 (66%)
LrchNP_609834.2 LRR <81..>286 CDD:443914 105/204 (51%)
leucine-rich repeat 124..146 CDD:275380 14/21 (67%)
leucine-rich repeat 147..167 CDD:275380 9/19 (47%)
leucine-rich repeat 169..192 CDD:275380 13/22 (59%)
leucine-rich repeat 193..215 CDD:275380 9/21 (43%)
leucine-rich repeat 216..237 CDD:275380 10/20 (50%)
leucine-rich repeat 238..260 CDD:275380 8/21 (38%)
leucine-rich repeat 261..279 CDD:275380 9/17 (53%)
CH_LRCH 667..755 CDD:409054 55/84 (65%)
CH_SF <1075..1099 CDD:469584
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.