Protein Alignment STIM2 and stim2b

DIOPT Version :10

• Sequence 1: NP_001162589.1
• Gene: STIM2 / 57620
• HGNCID: 19205
• Length: 754
• Species: Homo sapiens
• Sequence 2: NP_001422880.1
• Gene: stim2b / 563901
• ZFINID: ZDB-GENE-120404-3
• Length: 727
• Species: Danio rerio
• Alignment Length: 782
• Identity: 458/782 - (58%)
• Similarity: 551/782 - (70%)
• Gaps: 92/782 - (11%)

Human     1 MLVLGLLVAGAADGCE-LVPRHLRGRRATGSAATAASSPAAAAGDSPALMTDPCMSLSPPCFTEE 64
            :|:|..||..|..|.| .:..||..|        ....|||.|      .||||.::.|||..|.
Zfish     9 VLLLRGLVISAVLGLESSLTSHLANR--------VTPDPAAVA------PTDPCSAVMPPCTNEA 59

Human    65 DRFSLEALQTIHKQMDDDKDGGIEVEESDEFIREDMKYKDATNKHSHLHREDKHITIEDLWKRWK 129
            ||||||||:.||||:|||.||.|||.||.|||.|||| :..|||||:|||||:|||:|:||:.||
Zfish    60 DRFSLEALRHIHKQLDDDNDGAIEVNESVEFIIEDMK-QHQTNKHSNLHREDQHITVEELWRGWK 123

Human   130 TSEVHNWTLEDTLQWLIEFVELPQYEKNFRDNNVKGTTLPRIAVHEPSFMISQLKISDRSHRQKL 194
            .||||||||||.::||.|.|||||||:|||:..|.|.||||||.:||:||..||||.|:.|:|||
Zfish   124 ISEVHNWTLEDVVEWLKESVELPQYERNFREFKVDGNTLPRIAANEPAFMSMQLKILDQRHKQKL 188

Human   195 QLKALDVVLFGPLTRPPHNWMKDFILTVSIVIGVGGCWFAYTQNKTSKEHVAKMMKDLESLQTAE 259
            .|||||.|||||..|..::|:|||||.:||:||||||||||.|||:||.|:::|||||||||.||
Zfish   189 NLKALDAVLFGPPLRHHYHWLKDFILMISIIIGVGGCWFAYIQNKSSKIHISQMMKDLESLQHAE 253

Human   260 QSLMDLQERLEKAQEENRNVAVEKQNLERKMMDEINYAKEEACRLRELREGAECELSRRQYAEQE 324
            :||.:||.||||||||||.|||||||||:||.|||..||:||.|||||||||||||||.:|||:|
Zfish   254 ESLTELQSRLEKAQEENRTVAVEKQNLEQKMRDEITGAKKEASRLRELREGAECELSRLKYAEEE 318

Human   325 LEQVRMALKKAEKEFELRSSWSVPDALQKWLQLTHEVEVQYYNIKRQNAEMQLAIAKDEVAASYL 389
            |.|||||||:|||  :::|.||:|:|||.||||||||||||||||:||||:||.:||||
Zfish   319 LVQVRMALKRAEK--QMQSDWSLPEALQMWLQLTHEVEVQYYNIKKQNAELQLTVAKDE------ 375

Human   390 IQAEKIKKKRSTVFGTLHVAHSSSLDEVDHKILEAKKALSELTTCLRERLFRWQQIEKICGFQIA 454
              |||||||||:|||||||||||||||||||||||||||||:|.||||||.||||||::|||.:.
Zfish   376 --AEKIKKKRSSVFGTLHVAHSSSLDEVDHKILEAKKALSEVTACLRERLHRWQQIERLCGFPVV 438

Human   455 HNSGLPSLTSSLYSDHSWVVMPRVSIPPYPIAGGVDDLDEDTPPIVSQFPGTMAKPPGSLARSSS 519
            :||||||||:|||:|||||||||:|:|||||||||||||||||||:.||...:.:||  |.|:||
Zfish   439 NNSGLPSLTASLYADHSWVVMPRMSVPPYPIAGGVDDLDEDTPPIIPQFTSPLIRPP--LTRNSS 501

Human   520 LCRSRRSIVPSSPQPQRAQLAPHAPHPSHPRHPHHPQHTPHSLPSPDPDILSVSSCPALYRNEEE 584
            :||||||::..                            |.:| |.|||:||::|.|.:||.|.|
Zfish   502 VCRSRRSLMSQ----------------------------PTTL-SADPDLLSMASAPLVYRPEGE 537

Human   585 EEAIYFSAEKQWEVPDTASECDSLNSSIGRKQ-SPPLSLEIYQT---LSPRKISRDE-------- 637
            ||.|:|:.|::.:..||.|:.|||:||:|||| |.|.......|   ..||||||:|
Zfish   538 EEHIFFTVERKGDPQDTCSDSDSLSSSLGRKQFSGPAVQSTCVTGTETPPRKISREEFYPLEAQA 602

Human   638 VSLE---------DSSRGDSPVTVDVSWGSPDCV---GLTETKSMIFSPASKV--YNGILEKSCS 688
            ::||         .||..||.   .|..||||..   ...|.:::.|.|:::|  ||||||||.|
Zfish   603 LALETIMPPSTSSPSSFHDSS---SVHKGSPDLTRSSDFPEYQNLTFHPSTRVVAYNGILEKSYS 664

Human   689 MNQL-SSGIPVPKPRHTSCSSAGNDSKPVQEAPSVARISSIPHDLCHNGEKSKKPSKIKSLFKKK 752
            |.|| :||.|: :..:.|.||...:||.::|:..:...|  |.|.|.|||  ||.|||||||||.
Zfish   665 MGQLPASGTPL-EGHYPSISSLDIESKAIKESKQLQTTS--PQDSCDNGE--KKRSKIKSLFKKS 724

Human   753 SK 754
            .|
Zfish   725 KK 726

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
STIM2	NP_001162589.1	SAM_STIM2	132..205	CDD:188973	50/72 (69%)
		PRK00409	<250..430	CDD:234750	140/179 (78%)
		SOAR	346..453	CDD:465164	85/106 (80%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	491..570		29/78 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	693..754		27/60 (45%)
stim2b	NP_001422880.1	SAM_superfamily	126..199	CDD:472832	50/72 (69%)
		PRK03918	<234..>430	CDD:235175	158/205 (77%)
		SOAR	338..437	CDD:465164	85/106 (80%)