DRSC/TRiP Functional Genomics Resources

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Protein Alignment STIM2 and Stim

DIOPT Version :10

Sequence 1:NP_001162589.1 Gene:STIM2 / 57620 HGNCID:19205 Length:754 Species:Homo sapiens
Sequence 2:NP_523357.2 Gene:Stim / 32556 FlyBaseID:FBgn0045073 Length:570 Species:Drosophila melanogaster


Alignment Length:475 Identity:188/475 - (39%)
Similarity:278/475 - (58%) Gaps:44/475 - (9%)


- Green bases have known domain annotations that are detailed below.


Human    30 SAATAASSPAAAAGDSPALMTDPCMSLSPPCFTEEDRFSLEALQTIHKQMDDDKDGGIEVEESDE 94
            |..:.::..|.||.|.      .|.|.|     .:|||.:||:.::|:|:|||.:|.|::.|||:
  Fly   116 SMGSGSADGACAADDF------DCYSGS-----VQDRFGMEAIASLHRQLDDDDNGNIDLSESDD 169

Human    95 FIREDMKYKDATNKHS---HLHREDKHITIEDLWKRWKTSEVHNWTLEDTLQWLIEFVELPQYEK 156
            |:||::||.....|..   |.: :|.||::::||:.|..|||||||:|.|..||.:.|:||||..
  Fly   170 FLREELKYDSGYEKRQKAFHFN-DDMHISVKELWEAWLRSEVHNWTIEQTTDWLAQSVQLPQYVD 233

Human   157 NFRDNNVKGTTLPRIAVHEPSFMISQLKISDRSHRQKLQLKALDVVLFGPLTRPPHNWMKDFILT 221
            .|:.:.|.|..|||:||:...::.:.|.|.|..|:||:.|||:|||||||.......| ||:||.
  Fly   234 LFKLHKVTGAALPRLAVNNLQYVGNVLGIKDPIHKQKISLKAMDVVLFGPPRETGTRW-KDYILV 297

Human   222 VSIVIGVGGCWFAYTQNKTSKEHVAKMMKDLESLQTAEQSLMDLQERLEKAQEENRNVAVEKQNL 286
            ..::..:.|||:||.|||.:|.|:.:|.:|:|.||.|||||.::|:.||:|:.|..|||.||.:|
  Fly   298 TLLLSAIIGCWYAYQQNKNAKRHLRRMAQDMEGLQRAEQSLQEMQKELERARMEQENVATEKLDL 362

Human   287 ERKMMDEINYAKEEACRLRELREGAECELSRRQYAEQELEQVRMALKKAEKEFEL-RSSWSVPDA 350
            ||::        :||..|.......|.     |..::|:|.:|..|.:|  |||| .:.||.|..
  Fly   363 ERRL--------KEAPTLSSSNSDLEV-----QQLKKEIEMLRNELSRA--EFELVDNCWSPPPQ 412

Human   351 LQKWLQLTHEVEVQYYNIKRQNAEMQLAIAKDEVAASYLIQAEKIKKKRSTVFGTLHVAHSSSLD 415
            ||.|||.|:|:|.:.:..||.:||.||..|::        ..||::||||::.|.....|..|:|
  Fly   413 LQSWLQYTYELESKNHQKKRTSAEKQLQSARE--------ACEKLRKKRSSLVGAFVSTHGKSID 469

Human   416 EVDHKILEAKKALSELTTCLRERLFRWQQIEKICGFQIAHNSGLPSLTSSLYSDH----SWVVMP 476
            :||..|:||:.||.::|..|:|||.||:|||...|..|.:|:|||.|.:.||..:    |.:.|.
  Fly   470 DVDRSIVEARNALGDVTNELQERLHRWKQIETCLGLNIVNNNGLPYLENVLYGRNGGLQSSMGMS 534

Human   477 RVSIPPYPIAGGVDDLDEDT 496
            ........|....:|||:::
  Fly   535 STKGSRARITNSTEDLDDES 554

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
STIM2NP_001162589.1 SAM_STIM2 132..205 CDD:188973 36/72 (50%)
PRK00409 <250..430 CDD:234750 71/180 (39%)
SOAR 346..453 CDD:465164 45/106 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 491..570 3/6 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 693..754
StimNP_523357.2 SAM_STIM-1,2-like 209..282 CDD:188903 36/72 (50%)
YhaN 312..>501 CDD:443752 86/211 (41%)
SOAR 408..507 CDD:465164 45/106 (42%)
Blue background indicates that the domain is not in the aligned region.

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