Protein Alignment STIM2 and stim-1

DIOPT Version :10

• Sequence 1: NP_001162589.1
• Gene: STIM2 / 57620
• HGNCID: 19205
• Length: 754
• Species: Homo sapiens
• Sequence 2: NP_741074.1
• Gene: stim-1 / 175201
• WormBaseID: WBGene00021910
• Length: 530
• Species: Caenorhabditis elegans
• Alignment Length: 516
• Identity: 144/516 - (27%)
• Similarity: 232/516 - (44%)
• Gaps: 110/516 - (21%)

Human    65 DRFSLEALQTIHKQMDDDKDGGIEVEESDEFIREDMKYK--DATNKHSHLHREDKHITIEDLWKR 127
            |:...||::.||:.||||..|.|:..||..|::|||:.:  :.|.:.:..|.:|..||::|||:.
 Worm    40 DKLGYEAIRDIHRDMDDDHSGSIDRNESTGFMKEDMQMRGSERTRRENKFHGDDDAITVDDLWEA 104

Human   128 WKTSEVHNWTLEDTLQWLIEFVELPQYEKNFRDNNVKGTTLPRIAVHEPSFMISQLKISDRSHRQ 192
            |..|....||.|..::|||..|.||...:..:...:.|..|||.|.....|:..:|.|....:||
 Worm   105 WFESIERTWTNERLVEWLINDVNLPSIVEAVKAKKIDGKILPRFASPNSDFLNKELGIKSSVYRQ 169

Human   193 KLQLKALDVVLFGPLTRPPHNWMKDFILTVSIVIGVGGCWFAYTQNKTSKEHVAKMMKDLESLQT 257
            ||:|.:|||||||  .:..:|..|| ||...:.:.:....|.|.:.|                |.
 Worm   170 KLRLNSLDVVLFG--YKDNNNRTKD-ILLAFLALLLTSLIFLYVRQK----------------QK 215

Human   258 AEQSLMDLQERLEKAQEENRNVAVEKQNLERKMMDEINYAKEEACRLRELREGAECELSRRQYAE 322
            |:|.:.:|..:|    .|.:.:..|.:::::.:.||.:        .|.:.:|.        ...
 Worm   216 AQQKVNELSNKL----TELKCMETEFEDVQKMLNDERS--------KRSISDGV--------VNH 260

Human   323 QELEQVRMALKKAEKEFELRSSWS-VPDALQKWLQLTHEVEVQYYNIKRQNA--EMQLAIAKDEV 384
            .|:|.:|:.|::||:..|..|:.| .|.|||..|:.|.|.|:.:...:||:.  ||:.||.
 Worm   261 TEMENLRVQLEEAERRLEANSNGSQAPLALQPLLRRTCENEMAFLEKQRQDCFKEMKEAIE---- 321

Human   385 AASYLIQAEKIKKKRSTVFGTLHVA--HSSSLDEVDHKILEAKKALSELTTCLRERLFRWQQIEK 447
                  ..::::||:.:|..:|.:|  .:|:.|:||.||...|..:.::.|..||...||.|||.
 Worm   322 ------MVDRLQKKQGSVLSSLKLATGAASTSDQVDSKIFALKSRMEKIHTLTRETQERWLQIES 380

Human   448 ICGFQIAHNSGLPSLTSSLYSDHSW-------------------------VVMPRVSIPPYPIAG 487
            :|||.:.:.:....:..|:.|.|.:                         ..:.:|| ||.|.:.
 Worm   381 LCGFPLLYLNETEHINRSIASSHFYNKSHEGSSSSGSISNAHSNPNAVNSNFVKKVS-PPIPPSQ 444

Human   488 GVDDL------------DEDTPPIVSQFPGTMAKPPGSLARSSSLCR-----SRRSIVPSS 531
            ...:|            .|||.|||.           .:|.|.||.:     ..:|||..|
 Worm   445 QTANLRFVPTEQSDSIHSEDTSPIVE-----------DVAISRSLTQDLAEADMQSIVSGS 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
STIM2	NP_001162589.1	SAM_STIM2	132..205	CDD:188973	27/72 (38%)
		PRK00409	<250..430	CDD:234750	46/184 (25%)
		SOAR	346..453	CDD:465164	38/111 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	491..570		15/58 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	693..754
stim-1	NP_741074.1	SAM_superfamily	109..182	CDD:472832	27/72 (38%)
		SOAR	285..386	CDD:465164	37/110 (34%)