Protein Alignment WDFY1 and Wdfy2

DIOPT Version :10

• Sequence 1: NP_065881.1
• Gene: WDFY1 / 57590
• HGNCID: 20451
• Length: 410
• Species: Homo sapiens
• Sequence 2: NP_609400.1
• Gene: Wdfy2 / 34425
• FlyBaseID: FBgn0032246
• Length: 408
• Species: Drosophila melanogaster
• Alignment Length: 406
• Identity: 192/406 - (47%)
• Similarity: 278/406 - (68%)
• Gaps: 8/406 - (1%)

Human     1 MAAEIHSRPQ--------SSRPVLLSKIEGHQDAVTAALLIPKEDGVITASEDRTIRVWLKRDSG 57
            |||||....:        |.:|.||||:||..|.|.||:|||.|:|||:.|:|:|:|||||||||
  Fly     1 MAAEIKPAQRTNNDRFNTSKKPELLSKLEGSSDDVNAAILIPGENGVISVSDDKTVRVWLKRDSG 65

Human    58 QYWPSIYHTMASPCSAMAYHHDSRRIFVGQDNGAVMEFHVSEDFNKMNFIKTYPAHQNRVSAIIF 122
            ||||||...|.|.|:|:.|..:||.::|||:||.|.::.:|||.|:::|::.|.:||.||.|::|
  Fly    66 QYWPSICQYMPSGCTAIEYVSESRHLYVGQENGTVTQYALSEDCNRLSFLRDYLSHQARVMAVVF 130

Human   123 SLATEWVISTGHDKCVSWMCTRSGNMLGRHFFTSWASCLQYDFDTQYAFVGDYSGQITLLKLEQN 187
            |...:|::|.|.||..::.||.||..:|.:.|.:..:.||:|...:||||||::||||:|:.:..
  Fly   131 SKTHKWILSAGKDKQFAYHCTESGKRVGGYNFETPCTALQFDALAKYAFVGDHAGQITMLRCDVQ 195

Human   188 TCSVITTLKGHEGSVACLWWDPIQRLLFSGASDNSIIMWDIGGRKGRTLLLQGHHDKVQSLCYLQ 252
            ...:|||..||...:.||.|....:||||||.|.|:::||:||::|....||||.:||.:|.|..
  Fly   196 GVQLITTFNGHSAEIRCLKWVEGPQLLFSGACDQSVLVWDVGGKRGTIYELQGHSNKVSALSYAN 260

Human   253 LTRQLVSCSSDGGIAVWNMDVSREEAPQWLESDSCQKCEQPFFWNIKQMWDTKTLGLRQHHCRKC 317
            .|:||:||..|..:..|.|:..|:|.|.|:::::||.|.:|||||.:.|.|.|.||:||||||.|
  Fly   261 HTQQLISCGEDSVVVFWEMNAMRKEVPGWVDTNNCQLCSRPFFWNFRSMMDQKQLGIRQHHCRHC 325

Human   318 GQAVCGKCSSKRSSYPVMGFEFQVRVCDSCYDSIKDEDRTSLATFHEGKHNISHMSMDIARGLMV 382
            |:|||..||:.|.:.|:|||||.||.||.||..::..:|.|||:|::.||:|.:|.:|..|..::
  Fly   326 GKAVCDNCSTNRINIPIMGFEFDVRTCDPCYKQLQTVERPSLASFNDAKHSIVYMDLDEDRKRLL 390

Human   383 TCGTDRIVKIWDMTPV 398
            |.|.||::||||::.:
  Fly   391 TVGQDRLIKIWDLSNI 406

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
WDFY1	NP_065881.1	WD40	16..272	CDD:475233	122/255 (48%)
		WD 1	22..61		26/38 (68%)
		WD40 repeat	28..67	CDD:293791	27/38 (71%)
		WD 2	66..105		17/38 (45%)
		WD40 repeat	71..111	CDD:293791	16/39 (41%)
		WD 3	112..150		16/37 (43%)
		WD40 repeat	117..154	CDD:293791	14/36 (39%)
		WD 4	153..192		15/38 (39%)
		WD40 repeat	159..197	CDD:293791	17/37 (46%)
		WD 5	197..236		18/38 (47%)
		WD40 repeat	202..239	CDD:293791	16/36 (44%)
		WD 6	240..279		16/38 (42%)
		WD40 repeat	246..314	CDD:293791	30/67 (45%)
		FYVE_WDFY1	279..354	CDD:277295	41/74 (55%)
		WD40 repeat	321..363	CDD:293791	21/41 (51%)
		WD 7	364..403		14/35 (40%)
Wdfy2	NP_609400.1	WD40	24..279	CDD:475233	122/254 (48%)
		WD40 repeat	35..72	CDD:293791	27/36 (75%)
		WD40 repeat	80..117	CDD:293791	15/36 (42%)
		WD40 repeat	125..161	CDD:293791	14/35 (40%)
		WD40 repeat	166..205	CDD:293791	17/38 (45%)
		WD40 repeat	211..248	CDD:293791	17/36 (47%)
		WD40 repeat	253..283	CDD:293791	11/29 (38%)
		FYVE_WDFY1_like	287..356	CDD:277258	39/68 (57%)
		WD40 repeat	324..371	CDD:293791	24/46 (52%)