Protein Alignment KCNT1 and SLO2

DIOPT Version :10

• Sequence 1: XP_011517180.1
• Gene: KCNT1 / 57582
• HGNCID: 18865
• Length: 1283
• Species: Homo sapiens
• Sequence 2: NP_001097259.2
• Gene: SLO2 / 5740325
• FlyBaseID: FBgn0261698
• Length: 1878
• Species: Drosophila melanogaster
• Alignment Length: 1619
• Identity: 661/1619 - (40%)
• Similarity: 870/1619 - (53%)
• Gaps: 457/1619 - (28%)

Human    91 LLDTAGFKMSDLDSEVLPLPPRY-RFRDLLLGDP------------SFQNDDRVQVEFYVNENTF 142
            |.|.||:     ..:.||..|.. ||...:...|            |.:.|:||:||:|||||||
  Fly    47 LNDLAGY-----PPQQLPTAPAVRRFSKSIFQRPRSMSVWSDISRSSMRLDERVRVEYYVNENTF 106

Human   143 KERLKLFFIKNQRSSLRIRLFNFSLKLLTCLLYIVRVLLDDPALGIGCWGCP---KQNYSFNDSS 204
            ||||:|:||||||||||||:.:..||||:|:|||:||:||.....|.|:||.   |..:..:...
  Fly   107 KERLQLYFIKNQRSSLRIRIADLFLKLLSCVLYIIRVILDKNPTFITCYGCEVGNKTEFIISAKL 171

Human   205 SE--------INWAPILWVERKMTLWAIQVIVAIISFLETMLLIYLSYKGNIWEQIFRVSFVLEM 261
            :|        |||..||||.|...||.:|:::|::|..::::|.||.||||||:||....|:||:
  Fly   172 TEEEFQENPIINWDAILWVNRPTVLWVLQLLLAMVSLTQSLVLTYLGYKGNIWQQILSFHFILEL 236

Human   262 INTLPFIITIFWPPLRNLFIPVFLNCWLAKHALENMINDFHRAILRTQSAMFNQVLILFCTLLCL 326
            :.|:||.:||..|||||||||:||||||||.:||||.||.|||:.::|||:..|:.||..|||||
  Fly   237 VTTIPFALTIVHPPLRNLFIPIFLNCWLAKRSLENMFNDLHRAMQKSQSALSQQLTILSATLLCL 301

Human   327 VFTGGCRTCGIQHLERAG-ENLSLLTSFYFCIVTFSTVGYGDVTPKIWPSQLLVVIMICVALVVL 390
            |||.   .|||||.:||| .:|:|..|.|:.:||||||||||..|.||||||.:||||||||:||
  Fly   302 VFTS---VCGIQHFQRAGHRHLNLFQSTYYVVVTFSTVGYGDFVPDIWPSQLYMVIMICVALIVL 363

Human   391 PLQFEELVYLWMERQKSGGNYSRHRAQTEKHVVLCVSSLKIDLLMDFLNEFYAHPRLQDYYVVIL 455
            |.|||:|.:.||||||.||:||.||||:|||||:|.::|..|.:|||||||||||.|||:|||:|
  Fly   364 PTQFEQLAFTWMERQKLGGSYSSHRAQSEKHVVVCSTTLHADTIMDFLNEFYAHPLLQDFYVVLL 428

Human   456 CPTEMDVQVRRVLQIPLWSQRVIYLQGSALKDQDLMRAKMDNGEACFILSSRNEVDRTAADHQTI 520
            .|.|:|..:|.:||:|:|:|||||:|||.|||.||.||:|:..||||||::||..|:||||..||
  Fly   429 SPMELDTTMRMILQVPIWAQRVIYIQGSCLKDGDLARARMNEAEACFILAARNYADKTAADEHTI 493

Human   521 LRAWAVKDFAPNCPLYVQILKPENKFHVKFADHVVCEEECKYAMLALNCICPATSTLITLLVHTS 585
            ||:|||||||||.|.||||.:||:|.|||||:|||||:|.|||:||.||.||..|||:|||:|||
  Fly   494 LRSWAVKDFAPNVPQYVQIFRPEHKLHVKFAEHVVCEDEFKYALLANNCTCPGASTLVTLLLHTS 558

Human   586 RGQEGQESPEQWQRMYGRCSGNEVYHIRMGDSKFFREYEGKSFTYAAFHAHKKYGVCLIGLKRED 650
            ||||||:|||:|.|:||:|||||:|||.:|||:||.||||||||||:||:|:||||.|:|::..:
  Fly   559 RGQEGQQSPEEWHRLYGKCSGNEIYHIVLGDSRFFGEYEGKSFTYASFHSHRKYGVALVGVRPAE 623

Human   651 -----NKSILLNPGPRHILAASDTCFYINITKEENSAFIFKQEEKRKKRAF----SGQGLHEGPA 706
                 .::||||||||||:...|||:|::|||||||||:..|.:.....|.    ||.|...|.:
  Fly   624 LPEFYEETILLNPGPRHIMKKDDTCYYMSITKEENSAFVVNQNQTSDPTAAAKEGSGTGGGGGAS 688

Human   707 RLPVH------------------------------SIIASMGTVAMDLQ---------------- 725
            ....|                              |.:.|..|....:.
  Fly   689 SSASHHHTAATANPTTTITTTVQATTTTISTTFTSSTLLSASTTTATINATSTAAAAPPPVPSVC 753

Human   726 ----------------GTEH--------------------------------------------- 729
                            ||.|
  Fly   754 VRVPHSPSYDSGGGTTGTTHLQPYPYPQSYPQPHPPMQTPDSGEFASLFVPSENPTAVIISDSRQ 818

Human   730 ---------------------------RPTQSGGGGG---------------------------- 739
                                       .|:.:||.||
  Fly   819 NLKDTTVTQTAATITTTTLPPPPQTMGSPSMAGGSGGCGGGGLGLGSAHSMGTSLSITPATLTTT 883

Human   740 GSKLALPTENG------------SGSRRPSIAPVLELADSSAL---------------------- 770
            |:.|.:|..|.            .|||||||.||.::..||:.
  Fly   884 GNHLDVPFANNPNLLSPDVLNQRRGSRRPSILPVPDMFTSSSFSIAGNDDGEEGDESDDEIDDEM 948

Human   771 --------LPC-----------DLLSDQSEDE--------------------------------- 783
                    :.|           .|:...|||.
  Fly   949 PWRSPSEKIACLGGHFPQSRTYSLIMSSSEDSYQRGCSFCSATASASAAAVAVAVAAAPAPAPAP 1013

Human   784 VTPSDDEGLS------------------------------------------------------- 793
            ..|||..|.|
  Fly  1014 AYPSDSAGESGTNADSAAMPSEEYLPQLRRRVMKKSYSCDSECRSVPGMGMGMAMGVGLGGGTLA 1078

Human   794 -----------------------------------------------------------VVEY-- 797
                                                                       |.:|
  Fly  1079 RLAARRRQLQRCSSCSCSTATTTTTPAVAATTAMAAGSGATAFTSSSSVETRRPVRPVWVYDYSC 1143

Human   798 -VKGYPPNSPYIGSSPTLCHLLPVKAPFCCLRLDKGCKHNSYEDAKAYGFKNKLIIVSAETAGNG 861
             |||:||.||:||.|||||:||..|.|.|||:|.:.|:|.||.:||.|.::||.||::|:.|.||
  Fly  1144 IVKGFPPVSPFIGVSPTLCYLLKEKKPLCCLQLAQVCEHCSYRNAKEYQWQNKTIILAADYASNG 1208

Human   862 LYNFIVPLRAYYRSRKELNPIVLLLDNKPDHHFLEAICCFPMVYYMEGSVDNLDSLLQCGIIYAD 926
            :||||:||||::||:..||||:|||:.:||..||:|:..||:||:|.||:|.||.||:.||..|:
  Fly  1209 IYNFIIPLRAHFRSKTSLNPIILLLERRPDVAFLDALSYFPLVYWMLGSIDCLDDLLRAGITLAE 1273

Human   927 NLVVVDKESTMSAEEDYMADAKTIVNVQTMFRLFPSLSITTELTHPSNMRFMQFRAKDSYSLALS 991
            ::|||:||.:.|||||.::|..|||.||.||:.|||:...|||:..||||||||||.|.|:|.||
  Fly  1274 SVVVVNKELSNSAEEDSLSDCNTIVAVQNMFKFFPSIKSITELSQSSNMRFMQFRAHDKYALHLS 1338

Human   992 KLEKRERENGSNLAFMFRLPFAAGRVFSISMLDTLLYQSFVKDYMITITRLLLGLDTTPGSGYLC 1056
            |:||||:|.||::::|||||||||.|||.|||||||||:|||||:||..|||||:|..||||:|.
  Fly  1339 KMEKREKERGSHISYMFRLPFAAGAVFSASMLDTLLYQAFVKDYVITFVRLLLGIDQAPGSGFLT 1403

Human  1057 AMKITEGDLWIRTYGRLFQKLCSSSAEIPIGIYRTE-------SHV----------FSTSEPHDL 1104
            :|:||:.|:||||||||:|||||::.|||||||||:       |||          ||....|.:
  Fly  1404 SMRITKDDMWIRTYGRLYQKLCSTTCEIPIGIYRTQDTSNADTSHVSNSPVERWGPFSAFSRHCV 1468

Human  1105 RAQSQISVNVEDCEDTRE----VKG----PWGSRAGTGGSSQGRHTGGGDPAEHPLLRRKSLQWA 1161
            |.:..........:.|::    ::|    |.||  .|||:|..|      |...   |::|:...
  Fly  1469 RLRPSYDEETGTPDSTKDSTEMLRGVTYRPPGS--ATGGASSFR------PQPQ---RQRSVNCL 1522

Human  1162 RRLSRKAPKQAGRAAAAEWISQQRLSLYRRSERQELSELVKNRMKHLGLPTTGYDEMNDHQNTLS 1226
            ...|    ::.|.:.:.....:.|.:..::.||.|::.||::||:.|.|||..||::::.:|.||
  Fly  1523 GGCS----ERKGSSYSINLADEARDNHAQQIERAEIANLVRSRMESLNLPTIDYDDVSEKRNHLS 1583

Human  1227 YVLINPPPDTRLEPSDIVYLIRSDPLA-------HVASSSQSRKSSCSH-KL-SSCNPE 1276
            ||:|||..|.:||..|::||:|..|.:       | .|..:|..|.||: .| ::|.|:
  Fly  1584 YVIINPSCDLKLEEGDLIYLVRPSPFSAQKTFERH-NSRRKSNISFCSNINLGATCGPQ 1641

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNT1	XP_011517180.1	Ion_trans	207..390	CDD:459842	109/183 (60%)
		Ion_trans_2	322..398	CDD:462301	51/76 (67%)
		BK_channel_a	552..646	CDD:460947	68/93 (73%)
SLO2	NP_001097259.2	Ion_trans_2	<319..363	CDD:462301	29/43 (67%)
		BK_channel_a	525..619	CDD:460947	68/93 (73%)