Protein Alignment KCNT1 and kcnt1b

DIOPT Version :10

• Sequence 1: XP_011517180.1
• Gene: KCNT1 / 57582
• HGNCID: 18865
• Length: 1283
• Species: Homo sapiens
• Sequence 2: XP_073807699.1
• Gene: kcnt1b / 563670
• ZFINID: ZDB-GENE-141210-6
• Length: 1252
• Species: Danio rerio
• Alignment Length: 1245
• Identity: 970/1245 - (77%)
• Similarity: 1058/1245 - (84%)
• Gaps: 67/1245 - (5%)

Human    81 QRRPCAGDGALLDTAGFKMSDLDSEVLPLPPRYRFRDLLLGDPSFQNDDRVQVEFYVNENTFKER 145
            ||...:..|.:||.:..|::|:||||.|||||||||||||||.||||||||||||||||||||||
Zfish    33 QRNNSSNTGVILDISTLKLADVDSEVPPLPPRYRFRDLLLGDQSFQNDDRVQVEFYVNENTFKER 97

Human   146 LKLFFIKNQRSSLRIRLFNFSLKLLTCLLYIVRVLLDDPALGIGCWG----------CPK--QNY 198
            |||||||||||||||||||.|||||||||||:||.||||...:.|..          |.|  .||
Zfish    98 LKLFFIKNQRSSLRIRLFNLSLKLLTCLLYIIRVSLDDPTNQVTCARKHCANITDALCSKACANY 162

Human   199 SFNDSS--SEINWAPILWVERKMTLWAIQVIVAIISFLETMLLIYLSYKGNIWEQIFRVSFVLEM 261
            :.|.::  ::|||..|.||.|::.:|||||.||:||||:.|||:|||||||||||||::||::||
Zfish   163 TANLTADPTQINWELIFWVNRRVPVWAIQVTVALISFLQAMLLVYLSYKGNIWEQIFQISFIIEM 227

Human   262 INTLPFIITIFWPPLRNLFIPVFLNCWLAKHALENMINDFHRAILRTQSAMFNQVLILFCTLLCL 326
            |||:|||||||||||||:|:||||||||||.||||||||.||||.||.||||||||||.||||||
Zfish   228 INTVPFIITIFWPPLRNIFVPVFLNCWLAKSALENMINDLHRAIQRTHSAMFNQVLILICTLLCL 292

Human   327 VFTGGCRTCGIQHLERAGENLSLLTSFYFCIVTFSTVGYGDVTPKIWPSQLLVVIMICVALVVLP 391
            ||||   .||||||||||:||:|..:.|||||||||||||||||:||||||||||||||||||||
Zfish   293 VFTG---ACGIQHLERAGKNLTLFDALYFCIVTFSTVGYGDVTPRIWPSQLLVVIMICVALVVLP 354

Human   392 LQFEELVYLWMERQKSGGNYSRHRAQTEKHVVLCVSSLKIDLLMDFLNEFYAHPRLQDYYVVILC 456
            ||||||.||||||||||||||||||||||||||||:|||||||||||||||||||||||||||||
Zfish   355 LQFEELAYLWMERQKSGGNYSRHRAQTEKHVVLCVTSLKIDLLMDFLNEFYAHPRLQDYYVVILC 419

Human   457 PTEMDVQVRRVLQIPLWSQRVIYLQGSALKDQDLMRAKMDNGEACFILSSRNEVDRTAADHQTIL 521
            |||||:||||:|||||||||||||||||||||||||||||:.|||||||||||||||||||||||
Zfish   420 PTEMDIQVRRILQIPLWSQRVIYLQGSALKDQDLMRAKMDDAEACFILSSRNEVDRTAADHQTIL 484

Human   522 RAWAVKDFAPNCPLYVQILKPENKFHVKFADHVVCEEECKYAMLALNCICPATSTLITLLVHTSR 586
            ||||||||||||||||||||||||||||||||||||||.|||||||||:|||||||:||||||||
Zfish   485 RAWAVKDFAPNCPLYVQILKPENKFHVKFADHVVCEEEFKYAMLALNCVCPATSTLVTLLVHTSR 549

Human   587 GQEGQESPEQWQRMYGRCSGNEVYHIRMGDSKFFREYEGKSFTYAAFHAHKKYGVCLIGLKREDN 651
            |||||.|||||||.|||||||||||||:.|||||.||:|||||||:|||||||||||||.|||||
Zfish   550 GQEGQTSPEQWQRTYGRCSGNEVYHIRLMDSKFFGEYDGKSFTYASFHAHKKYGVCLIGTKREDN 614

Human   652 KSILLNPGPRHILAASDTCFYINITKEENSAFIFKQEEKRKKRAFSGQGLHEGPARLPVHSIIAS 716
            ||||||||||||::|:|||:|||||||||||||||||||..| ..|..|:::.|:||||.|||||
Zfish   615 KSILLNPGPRHIMSATDTCYYINITKEENSAFIFKQEEKHSK-GLSAAGVYDAPSRLPVQSIIAS 678

Human   717 M-------GTVAMDLQGTEHRPTQSGGGGGGSKLALPTENGSGSRRPSIAPVLELADSSALLPCD 774
            |       ||||:|||..: .|..|      :|||||||||:||||||||||||:|||||:||||
Zfish   679 MVDQSTSYGTVAIDLQNPD-PPADS------NKLALPTENGAGSRRPSIAPVLEIADSSAILPCD 736

Human   775 LLSDQSEDEVTPSDDEGLSVVEYVKGYPPNSPYIGSSPTLCHLLPVKAPFCCLRLDKGCKHNSYE 839
            ||:|.||||...||::|...::.|||||||||||||||||||||..|||||||||||||:|||:|
Zfish   737 LLNDPSEDETNQSDEDGAPAIDCVKGYPPNSPYIGSSPTLCHLLQQKAPFCCLRLDKGCRHNSFE 801

Human   840 DAKAYGFKNKLIIVSAETAGNGLYNFIVPLRAYYRSRKELNPIVLLLDNKPDHHFLEAICCFPMV 904
            |||||||||||||||||||||||||||||||||||.|||||||||||||.||:||||||||||||
Zfish   802 DAKAYGFKNKLIIVSAETAGNGLYNFIVPLRAYYRPRKELNPIVLLLDNPPDNHFLEAICCFPMV 866

Human   905 YYMEGSVDNLDSLLQCGIIYADNLVVVDKESTMSAEEDYMADAKTIVNVQTMFRLFPSLSITTEL 969
            |||.|::||||:|||||||||||||||||||||||||||||||||||||||||||||||||.|||
Zfish   867 YYMAGTIDNLDNLLQCGIIYADNLVVVDKESTMSAEEDYMADAKTIVNVQTMFRLFPSLSIITEL 931

Human   970 THPSNMRFMQFRAKDSYSLALSKLEKRERENGSNLAFMFRLPFAAGRVFSISMLDTLLYQSFVKD 1034
            |||||||||||||||.||||||||||.||:.||||||||||||||||||||||||||||||||||
Zfish   932 THPSNMRFMQFRAKDCYSLALSKLEKIERDKGSNLAFMFRLPFAAGRVFSISMLDTLLYQSFVKD 996

Human  1035 YMITITRLLLGLDTTPGSGYLCAMKITEGDLWIRTYGRLFQKLCSSSAEIPIGIYRTESHVFSTS 1099
            |||.|.|||||||||||||||||||:||.|||||||||||||||||||||||||||||||:||:|
Zfish   997 YMILIARLLLGLDTTPGSGYLCAMKVTEEDLWIRTYGRLFQKLCSSSAEIPIGIYRTESHMFSSS 1061

Human  1100 EPHDLRAQSQISVNVEDCEDTREVKGPWGSRAGTGGSSQGRHTGGGDPAEHPLLRRKSLQWARRL 1164
            |..::..|    |:||||||.|:.:..|..:      :..|::.|.|.:||||||:||:||||||
Zfish  1062 EFKEICKQ----VSVEDCEDQRDHRESWKEK------TAHRNSTGSDQSEHPLLRKKSMQWARRL 1116

Human  1165 SRKAPKQAGRAAAAEWISQQRLSLYRRSERQELSELVKNRMKHLGLPTTGY-------------- 1215
            |||..|...|   ||.|:||||:|||||||||||||||||||||||||.||
Zfish  1117 SRKNTKPPSR---AERINQQRLNLYRRSERQELSELVKNRMKHLGLPTVGYEDVANLTASDVMNR 1178

Human  1216 -------DEMNDHQNTLSYVLINPPPDTRLEPSDIVYLIRSDPLAHVASSSQSRKSSCSHKLSSC 1273
                   |||||:|||||||||||||||.||.:||||:|||||||||..:.....:....: ...
Zfish  1179 VNLGYLQDEMNDNQNTLSYVLINPPPDTILELNDIVYIIRSDPLAHVPENLPGAPAGAKIR-QDY 1242

Human  1274 NPETRDETQL 1283
            .|||||||.|
Zfish  1243 RPETRDETHL 1252

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNT1	XP_011517180.1	Ion_trans	207..390	CDD:459842	146/182 (80%)
		Ion_trans_2	322..398	CDD:462301	64/75 (85%)
		BK_channel_a	552..646	CDD:460947	83/93 (89%)
kcnt1b	XP_073807699.1	None