Protein Alignment KIF17 and kif17

DIOPT Version :9

• Sequence 1: NP_065867.2
• Gene: KIF17 / 57576
• HGNCID: 19167
• Length: 1029
• Species: Homo sapiens
• Sequence 2: NP_001373250.1
• Gene: kif17 / 557863
• ZFINID: ZDB-GENE-080724-12
• Length: 823
• Species: Danio rerio
• Alignment Length: 1037
• Identity: 510/1037 - (49%)
• Similarity: 645/1037 - (62%)
• Gaps: 235/1037 - (22%)

Human     1 MASEAVKVVVRCRPMNQRERELRCQPVVTVDCARAQCCIQNPGAADEPPKQFTFDGAYHVDHVTE 65
            ||||:|||||||||:|.||:.:.|:.||:||....||.|:.||..:||||||||||.|:::|.||
Zfish     1 MASESVKVVVRCRPLNNREKAMNCKIVVSVDSTHCQCFIKKPGDTEEPPKQFTFDGTYYINHSTE 65

Human    66 QIYNEIAYPLVEGVTEGYNGTIFAYGQTGSGKSFTMQGLPDPPSQRGIIPRAFEHVFESVQCAEN 130
            ::||||||||||||||||||||||||||||||||||||:||||||||||||||||:||::|||||
Zfish    66 EVYNEIAYPLVEGVTEGYNGTIFAYGQTGSGKSFTMQGVPDPPSQRGIIPRAFEHIFETIQCAEN 130

Human   131 TKFLVRASYLEIYNEDVRDLLGADTKQKLELKEHPEKGVYVKGLSMHTVHSVAQCEHIMETGWKN 195
            |||||||||||||.|::|||||.|.|||:|||||||:||||:.|:|.|||||.:||.:|:.||:|
Zfish   131 TKFLVRASYLEIYKEEIRDLLGKDIKQKMELKEHPERGVYVRDLTMQTVHSVGECERVMDLGWRN 195

Human   196 RSVGYTLMNKDSSRSHSIFTISIEMSAVDERGKDHLRAGKLNLVDLAGSERQSKTGATGERLKEA 260
            |||||||||||||||||||||.:|:.::|..|.:|||||||||||||||||||||||||:||:||
Zfish   196 RSVGYTLMNKDSSRSHSIFTIHLEICSIDTAGDEHLRAGKLNLVDLAGSERQSKTGATGDRLQEA 260

Human   261 TKINLSLSALGNVISALVDGRCKHVPYRDSKLTRLLQDSLGGNTKTLMVACLSPADNNYDETLST 325
            |||||||||||||||||||||.|::|||||||||||||||||||:||||||||||||||:|::||
Zfish   261 TKINLSLSALGNVISALVDGRSKYIPYRDSKLTRLLQDSLGGNTRTLMVACLSPADNNYEESIST 325

Human   326 LRYANRAKNIRNKPRINEDPKDALLREYQEEIKKLKAILTQQMSPSSLSALLSRQVPPDPVQVEE 390
            ||||||||:|:|:||||||||||||||||||||||:|:::.|:...:||:.|:.|...:...|..
Zfish   326 LRYANRAKSIQNRPRINEDPKDALLREYQEEIKKLRALISGQLGSGNLSSFLAGQKSGEASAVVS 390

Human   391 KLLPQPVIQHDVEAEKQLIREEYEERLARLKADYKAEQESRARLEEDITAMRNSYDVRLSTLEEN 455
            :  ||.... :.||||..|:||||::||||:|:|.|||||:.:|:|||.|:|.||:.|||:||.:
Zfish   391 R--PQSNTS-ESEAEKDKIKEEYEKKLARLQAEYDAEQESKVKLQEDIAALRTSYETRLSSLERS 452

Human   456 LRKETEAVLQVGVLYKAEVMSRAEFASSAEYPPAFQYETVVKPKVFSTTDTLPSDDVSKTQVSSR 520
            ....|.....|.:....|....|..||.
Zfish   453 RGSRTHTTGGVHLQQHKEEPITASAASQ------------------------------------- 480

Human   521 FAELPKVEPSKSEISLGSSESSSLEETSVSEAFPGPEEPSNVEVSMPTEESRSRYFLDECLGQEA 585
              |..|::.|:||                       |.||:|:.::
Zfish   481 --EQAKIDHSESE-----------------------ERPSSVDATV------------------- 501

Human   586 AGHLLGEQNYLPQEEPQEVPLQGLLGLQDPFAEVEAKLARLSSTVARTDAPQADVPKVPVQVPAP 650
            .|...||...|                                     |:...|:|
Zfish   502 KGAASGESQIL-------------------------------------DSVVVDIP--------- 520

Human   651 TDLLEPSDARPEAEAADDFPPRPEVDLASEVALEVVRTAEPGVWLEAQAPVALVAQPEPLPATAG 715
                                                                             
Zfish   521 ----------------------------------------------------------------- 520

Human   716 VKRESVGMEVAVLTDDPLPVVDQQQVLARLQLLEQQVVGGEQAKNKDLKEKHKRRKRYADERRKQ 780
                  |.            :||:..|.|||.|||:.|||||.:|::||::||:||..||:|:||
Zfish   521 ------GQ------------LDQKLALERLQQLEQEFVGGEQVRNEELKQRHKQRKTLADQRKKQ 567

Human   781 LVAALQNSDEDSGDWVLLNVYDSIQEEVRAKSKLLEKMQRKLRAAEVEIKDLQSEFQLEKIDYLA 845
            |:.||..|.|| ||.|||||||||||||.|||:.||..|:||:||::||:|||:||::|:.||||
Zfish   568 LIEALNQSSED-GDSVLLNVYDSIQEEVHAKSRHLENTQKKLKAAKLEIRDLQAEFEMERNDYLA 631

Human   846 TIRRQERDSMLLQQLLEQVQPLIRRDCNYSNLEKILRESCWDEDNGFWKIPHPVITKTSLPVAVS 910
            ||||.||:..|||.:||::..|:|||||||||:::.:|:.|||:.|.|::|..::.||:||....
Zfish   632 TIRRLEREGQLLQGILERMVSLVRRDCNYSNLDRLRKEAVWDEEGGTWRLPDVLVQKTTLPAVPP 696

Human   911 TG---PQNKPARKTSAADNGEP---NMEDDRYRLMLSRSNSENIASNYFRSKRASQILSTDARKS 969
            :|   |....||:.||:|..:|   ..|.|||:.||:||:||:||:||||.||:||:|:||:.|:
Zfish   697 SGVIAPGRLSARRNSASDLADPFVQEEEQDRYKEMLNRSDSEHIATNYFRPKRSSQLLATDSVKN 761

Human   970 LTHHNSPPGLSCPLSNNSAIPPTQAP-------EMPQPRPFRLESLDIPFT--KAKRKKSKS 1022
            ..:.:|      .:||.||...:...       |...|||||||||.:|.:  |.||||||:
Zfish   762 SMNFSS------SVSNGSAHQSSSGSGLSALTVESILPRPFRLESLGVPASHGKVKRKKSKT 817

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KIF17	NP_065867.2	Motor_domain	4..335	CDD:277568	262/330 (79%)
		Kinesin	11..335	CDD:278646	256/323 (79%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	523..569		9/45 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	647..673		0/25 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	908..931		8/28 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	968..1029		24/64 (38%)
kif17	NP_001373250.1	Motor_domain	4..335	CDD:419868	262/330 (79%)
		Smc	395..>650	CDD:224117	136/466 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194327488
Domainoid	1	1.000	547	1.000	Domainoid score	I2174
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5883
Inparanoid	1	1.050	682	1.000	Inparanoid score	I4447
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG41791
OrthoDB	1	1.010	-	-		D145782at33208
OrthoFinder	1	1.000	-	-		FOG0006941
OrthoInspector	1	1.000	-	-		oto43332
orthoMCL	1	0.900	-	-		OOG6_107365
Panther	1	1.100	-	-	LDO	PTHR24115
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2703
SonicParanoid	1	1.000	-	-		X5033
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	18	18.400