Protein Alignment KIF17 and cmet

DIOPT Version :10

• Sequence 1: XP_047282102.1
• Gene: KIF17 / 57576
• HGNCID: 19167
• Length: 1063
• Species: Homo sapiens
• Sequence 2: NP_524993.3
• Gene: cmet / 53561
• FlyBaseID: FBgn0040232
• Length: 2189
• Species: Drosophila melanogaster
• Alignment Length: 1231
• Identity: 290/1231 - (23%)
• Similarity: 466/1231 - (37%)
• Gaps: 374/1231 - (30%)

Human     3 SEAVKVVVRCRPMNQRERELRCQPVVT----VDCARAQCCIQNPGAADEPPKQFTFDGAYHVDHV 63
            :.:::|.::.||         |:|.:|    |...|      :...||...:.:.||..:.....
  Fly     6 ASSIQVCIKVRP---------CEPGLTSLWQVKERR------SIHLADSHAEPYVFDYVFDEGAS 55

Human    64 TEQIYNEIAYPLVEGVTEGYNGTIFAYGQTGSGKSFTMQGLPDPPSQRGIIPRAFEHVFESVQCA 128
            .:::::.:|..:|....:|:||||||||||.|||::||.|....|   |::..|.:.:|:.:...
  Fly    56 NQEVFDRMAKHIVHACMQGFNGTIFAYGQTSSGKTYTMMGDEQNP---GVMVLAAKEIFQQISSE 117

Human   129 ENTKFLVRASYLEIYNEDVRDLLGADTKQKLELKEHPEKGVYVKGLSMHTVHSVAQCEHIMET-- 191
            ....||:|..|:|||||.:.|||   .|:..:||.| |.|..:..::         ||..:.|
  Fly   118 TERDFLLRVGYIEIYNEKIYDLL---NKKNQDLKIH-ESGNGIVNVN---------CEECIITSE 169

Human   192 ---------GWKNRSVGYTLMNKDSSRSHSIFTISIEMSAVDERGKDHLRAGKLNLVDLAGSERQ 247
                     |.|.|:||.|.||:.|||||:||.|.||....|....|.:....|||||||||||.
  Fly   170 VDLLRLLCLGNKERTVGETNMNERSSRSHAIFKIIIESRKSDHSDDDAVIQSVLNLVDLAGSERA 234

Human   248 SKTGATGERLKEATKINLSLSALGNVISAL---VDGRCKHVPYRDSKLTRLLQDSLGGNTKTLMV 309
            .:|||.|.||||...||.||..|.|||.:|   .|.|..:  ||||||||:||.|||||..|.::
  Fly   235 DQTGARGARLKEGGHINKSLLFLSNVIKSLSENADNRFTN--YRDSKLTRILQASLGGNAFTSII 297

Human   310 ACLSPADNNYDETLSTLRYANRAKNIRNKPRINEDPKDA-LLREYQEEIKKLKAILTQQMSPSSL 373
            ..:.|  :..:|:.|||.:|.|||.||.||::||...|| :::..:.|||.||..|.::...:..
  Fly   298 CTIKP--SIMEESQSTLSFATRAKKIRIKPQVNEMVSDATMMKRLEREIKVLKDKLAEEERKNEN 360

Human   374 SAL---LSRQVPPDPVQV-----------------------------------EEKL-------- 392
            ...   |.||:..|..::                                   |:::
  Fly   361 QQKVEHLERQIKHDMHKIICGHSLSDKGQQKRRRTWCPTASGSHLELAETGTTEDRIDQFPKVSH 425

Human   393 LPQPVIQH---------------------DVEAEKQLIREEY----------------------- 413
            ||:||..|                     |:..|...|.||:
  Fly   426 LPKPVFFHTSNAGKRWDNIPKTINILGSLDIGTESNSISEEFLPAECIDFGSPRPDVLKPMLTIR 490

Human   414 ---------------------------------------------EERLARLKADY-KAEQESRA 432
                                                         :|:||.:.|.. ..||||.|
  Fly   491 QLPDLPLTPKGPLTTDKIKKEIQDLQMFTSLEKHFEVECEEVQGLKEKLAEVTAQRDNLEQESLA 555

Human   433 R------LEEDITAMR----------NSYDVRLSTLEENLR-KETEAVLQVGVLYKAEVMS---- 476
            .      ||:::|::|          :..:.:||||::.:| .|.|..:.||:.::.|...
  Fly   556 EKERYDALEKEVTSLRADNEAANSKISELEEKLSTLKQTMRIMEVENQVAVGLEFEFEAHKKSSK 620

Human   477 -RAEFASSAEYPPAFQYETVVKPKVFSTTDTL-------------PSDDVSKTQVSSRFAELPK- 526
             |.:...||........|::.|.....|.|.|             ..:|::...:.::..||.|
  Fly   621 LRVDDLLSALLEKESTIESLQKSLDNLTRDVLRNSKEGHMLSIAPEQEDIAGDSICNKCEELEKL 685

Human   527 VEPSKSEISLGSSESSSLEETSVSEAFPGPEEPSNVEVSMPTEESR--SRYFLDECLGQEAAGHL 589
            :...:|:.:....:...||..||.:.....|...|:..|...:::.  .|...:....|.|.|.|
  Fly   686 IADLESKKNSCECDQLRLEIVSVRDKLESVESAFNLASSEIIQKATDCERLSKELSTSQNAFGQL 750

Human   590 LGEQNYLPQEEPQEVPLQGLLGLQDPFAEVEAKLARL------------SSTVARTDAPQADVPK 642
              ::.|...::..:....|:..|.:....|:.|..:|            |::.|.....|.|..|
  Fly   751 --QERYDALDQQWQAQQAGITTLHEKHEHVQEKYQKLQEEYEQLESRARSASSAEFQRLQNDNTK 813

Human   643 VPVQVPAPTDLLEP----------SDARPE-------------AEAADDFPP-RPEVDLASEVAL 683
            ....:.:..:.||.          |::..|             .|...:|.. :.|.|..|...:
  Fly   814 FQADIASLNERLEEAQNMLTEVQNSESTVEKLRIQNHELTAKIKELETNFEEMQREYDCLSNQLM 878

Human   684 EVVRTAEPGVWLEAQAPVALVAQPEPLPATAGVKRESVGMEVAVLTDDPLPVVDQQQVLARLQLL 748
            |.|:..:           ||..:.:..| |:.|:.   .|..:.::.|    .|:|:  ..:.||
  Fly   879 ESVQEND-----------ALREEIKQRP-TSHVEE---SMRSSGISSD----FDEQK--QDINLL 922

Human   749 EQQVVGGEQAKNKDLKEKHKRRKR------------------------YADERRKQ--------- 780
            .|.|...|..:..:| :.|....|                        |.:|..:|
  Fly   923 HQFVQLSESVQQIEL-QHHSGISRLFRANQMKLDQSEPGLKLCLESAEYIEEDNRQSDATEPICL 986

Human   781 ---------LVAALQNSDEDSGDWV-LLNVYDSIQEEVRAKSKLLEKMQRKLRAAEVEIKDLQSE 835
                     .:..|.....|.|:.. ||::...:::|:..||.|:|..:..:.....::.:|:|.
  Fly   987 KGFLKRHRFQIKRLSQEHVDMGEEKRLLDIISQLEQEIEEKSALMEATEATINEMREQMTNLESA 1051

Human   836 FQLEKI-------DYLATIRRQERDSMLLQQLLEQVQPLIRRDCNYSNLEKILRESCWDEDNGFW 893
            . |||.       ||...|...|:.:..:..:.|::|..:.|:.:.|  |.:||... |||
  Fly  1052 L-LEKSVIINKVEDYQRQIESLEKQNAEMTMVYEELQDRVTRESSMS--ESLLRVPP-DED---- 1108

Human   894 KIPHPVITKTSLPQFQLGHRTNQPAKPLQQTMASRTWRTTATGSCSVGATVKTLPATTSDL 954
                      :||        ..|..|.::.....|.:|:.|          .|.:..|||
  Fly  1109 ----------TLP--------GCPTSPSRREQEVATLKTSIT----------ELQSQVSDL 1141

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KIF17	XP_047282102.1	Motor_domain	4..335	CDD:473979	131/348 (38%)
cmet	NP_524993.3	Motor_domain	8..321	CDD:473979	131/347 (38%)
		SMC_prok_B	539..1431	CDD:274008	129/663 (19%)
		SMC_prok_B	1137..1926	CDD:274008	3/5 (60%)
		YhaN	1717..2182	CDD:443752