DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KIF17 and Kif17

DIOPT Version :9

Sequence 1:	NP_065867.2	Gene:	KIF17 / 57576	HGNCID:	19167	Length:	1029	Species:	Homo sapiens
Sequence 2:	XP_038967234.1	Gene:	Kif17 / 500571	RGDID:	1562511	Length:	1075	Species:	Rattus norvegicus

Alignment Length:	1079	Identity:	834/1079 - (77%)
Similarity:	906/1079 - (83%)	Gaps:	54/1079 - (5%)

- Green bases have known domain annotations that are detailed below.

Human     1 MASEAVKVVVRCRPMNQRERELRCQPVVTVDCARAQCCIQNPGAADEPPKQFTFDGAYHVDHVTE 65
            ||||:|||||||||||:|||||.||.||||||||.||.||||||||||||||||||||:::|.||
  Rat     1 MASESVKVVVRCRPMNKRERELNCQSVVTVDCARGQCFIQNPGAADEPPKQFTFDGAYYIEHFTE 65

Human    66 QIYNEIAYPLVEGVTEGYNGTIFAYGQTGSGKSFTMQGLPDPPSQRGIIPRAFEHVFESVQCAEN 130
            |||||||||||||||||||||||||||||||||||||||||||.|||||||||||||||||||||
  Rat    66 QIYNEIAYPLVEGVTEGYNGTIFAYGQTGSGKSFTMQGLPDPPCQRGIIPRAFEHVFESVQCAEN 130

Human   131 TKFLVRASYLEIYNEDVRDLLGADTKQKLELKEHPEKGVYVKGLSMHTVHSVAQCEHIMETGWKN 195
            |||||||||||||||||||||||||||:||||||||||||||||||||||:|||||.:|||||||
  Rat   131 TKFLVRASYLEIYNEDVRDLLGADTKQRLELKEHPEKGVYVKGLSMHTVHNVAQCERVMETGWKN 195

Human   196 RSVGYTLMNKDSSRSHSIFTISIEMSAVDERGKDHLRAGKLNLVDLAGSERQSKTGATGERLKEA 260
            |:|||||||||||||||||||:||:.|||||||||||||||||||||||||||||||||||||||
  Rat   196 RAVGYTLMNKDSSRSHSIFTINIEIYAVDERGKDHLRAGKLNLVDLAGSERQSKTGATGERLKEA 260

Human   261 TKINLSLSALGNVISALVDGRCKHVPYRDSKLTRLLQDSLGGNTKTLMVACLSPADNNYDETLST 325
            ||||||||||||||||||||||||:||||||||||||||||||||||||||||||||||||||||
  Rat   261 TKINLSLSALGNVISALVDGRCKHIPYRDSKLTRLLQDSLGGNTKTLMVACLSPADNNYDETLST 325

Human   326 LRYANRAKNIRNKPRINEDPKDALLREYQEEIKKLKAILTQQMSPSSLSALLSRQVPPDPVQVEE 390
            ||||||||||:||||||||||||||||||||||:|||||.|||.|.:||||||.|.|..||..||
  Rat   326 LRYANRAKNIKNKPRINEDPKDALLREYQEEIKRLKAILAQQMGPGNLSALLSTQTPSGPVHPEE 390

Human   391 KLLPQPVIQHDVEAEKQLIREEYEERLARLKADYKAEQESRARLEEDITAMRNSYDVRLSTLEEN 455
            ||.....:|.|.|||||:||||||||||||||||:||||||.||:||||||||||||:||||:||
  Rat   391 KLPSPTTVQQDTEAEKQMIREEYEERLARLKADYEAEQESRVRLQEDITAMRNSYDVKLSTLQEN 455

Human   456 LRKET---------------------------EAVLQVGVLYKAEVMSRAEFASSAEYPPAFQYE 493
            ||||.                           ||||:..||.|.|||||||..|..||.|..|||
  Rat   456 LRKEKETGALCPGAAWEPTSCVPYTWAKGPLHEAVLKAEVLCKTEVMSRAEVTSGPEYSPPLQYE 520

Human   494 TVVKPKVFSTTDTLPSDDVSKTQVSSRFAELPKVEPSKSEISLGSSESSSLEETSVSEAFPGPEE 558
            |.|||.|.|..|.||..:|:::| :...:|.|.:|||:||: ..|:|||:||::|:|||:|||||
  Rat   521 TAVKPTVLSMPDMLPRGEVTRSQ-APLTSEEPNMEPSRSEV-FESNESSNLEDSSMSEAYPGPEE 583

Human   559 PSNVEVSMPTEESRSRYFLDECLGQEAAGHLLGEQNYLPQEEPQEVPLQGLLGLQDPFAEVEAKL 623
            .||||.|||...:.||||.||.|..||||..| |..:..|:||...||:.|..||||||||||||
  Rat   584 LSNVEFSMPGVLAESRYFPDEYLNPEAAGCPL-EAEHSVQDEPTLEPLRILASLQDPFAEVEAKL 647

Human   624 ARLSSTVARTDAPQADVPKVPVQVPAPTDLLEPSDARPEAEAADDFPPRPEVDLASEVALEVVRT 688
            ||||||||.||..|..||:||.|.|:.||||||||.:.|.:.||:...|.|.||:.:||.|||..
  Rat   648 ARLSSTVAMTDLSQTVVPQVPQQQPSSTDLLEPSDTKSEVDVADNVLLRTEPDLSMKVAEEVVSE 712

Human   689 AEPGVWLEAQAPVALV------AQPEPLPATAGVKRESVGMEVAVLTDDPLPVVDQQQVLARLQL 747
            ||.|||:|::|.||.|      |||:||.|.|.|:|||:|:||||||::..| ||||||||||||
  Rat   713 AETGVWMESEAHVAHVAQVSEEAQPQPLLAMASVRRESIGVEVAVLTEELQP-VDQQQVLARLQL 776

Human   748 LEQQVVGGEQAKNKDLKEKHKRRKRYADERRKQLVAALQNSDEDSGDWVLLNVYDSIQEEVRAKS 812
            ||||||||||||||||||||:|||||||||:||||||||||||||||||||||||||||||||||
  Rat   777 LEQQVVGGEQAKNKDLKEKHRRRKRYADERKKQLVAALQNSDEDSGDWVLLNVYDSIQEEVRAKS 841

Human   813 KLLEKMQRKLRAAEVEIKDLQSEFQLEKIDYLATIRRQERDSMLLQQLLEQVQPLIRRDCNYSNL 877
            |||||||:||||||||||||||||||||||||||||||||||||.||||||||||||||||||||
  Rat   842 KLLEKMQKKLRAAEVEIKDLQSEFQLEKIDYLATIRRQERDSMLFQQLLEQVQPLIRRDCNYSNL 906

Human   878 EKILRESCWDEDNGFWKIPHPVITKTSLPVAVSTGPQNKPARKTSAADNGEPNM-EDDRYRLMLS 941
            |||.|||.|||||||||||.|:|.||||||||.||.||||||||||.|:|||:| |:|||:||||
  Rat   907 EKIRRESSWDEDNGFWKIPEPIILKTSLPVAVPTGTQNKPARKTSAVDSGEPHMQEEDRYKLMLS 971

Human   942 RSNSENIASNYFRSKRASQILSTDARKSL-------TH---------HNSPPGLSCPLSNNSAIP 990
            ||:|||||||||||||||||||||..|||       ||         |||||||:..|||:||:|
  Rat   972 RSDSENIASNYFRSKRASQILSTDPMKSLNCSTLEPTHPPRRSRRSYHNSPPGLNSSLSNSSALP 1036

Human   991 PTQAPEMPQPRPFRLESLDIPFTKAKRKKSKSNFGSEPL 1029
            |.|.||:|||||||||||||||:|||||||||:|..|||
  Rat  1037 PAQTPEIPQPRPFRLESLDIPFSKAKRKKSKSSFSGEPL 1075

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KIF17	NP_065867.2	Motor_domain	4..335	CDD:277568	310/330 (94%)
		Kinesin	11..335	CDD:278646	304/323 (94%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	523..569		29/45 (64%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	647..673		12/25 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	908..931		18/22 (82%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	968..1029		48/76 (63%)
Kif17	XP_038967234.1	Motor_domain	4..335	CDD:419868	310/330 (94%)
Kif17	XP_038967234.1	Smc	<631..>899	CDD:224117	208/268 (78%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83680139
Domainoid	1	1.000	955	1.000	Domainoid score	I1750
eggNOG	0	0.000	Not matched by this tool.
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5883
Inparanoid	1	1.050	1593	1.000	Inparanoid score	I2420
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG41791
OrthoDB	1	1.010	-	-		D145782at33208
OrthoFinder	1	1.000	-	-		FOG0006941
OrthoInspector	1	1.000	-	-		oto128636
orthoMCL	1	0.900	-	-		OOG6_107365
Panther	1	1.100	-	-	LDO	PTHR24115
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5033
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	16.410