Protein Alignment KIF17 and sub

DIOPT Version :10

• Sequence 1: XP_047282102.1
• Gene: KIF17 / 57576
• HGNCID: 19167
• Length: 1063
• Species: Homo sapiens
• Sequence 2: NP_611260.1
• Gene: sub / 44870
• FlyBaseID: FBgn0003545
• Length: 628
• Species: Drosophila melanogaster
• Alignment Length: 660
• Identity: 164/660 - (24%)
• Similarity: 244/660 - (36%)
• Gaps: 221/660 - (33%)

Human     7 KVVVRCRPMNQRERE--LRCQPVVTVDCARAQCCIQNPGAADEPPKQFTFDGAYHVDHVTEQIYN 69
            :|.:|.||:....:.  :..:..|.:...:......|   .:...|.|.|...:........||:
  Fly    89 QVFLRLRPVKDASKAYIVSEEANVLITSCKVDSTSNN---VNRMEKHFGFTSIFDSTVGQRDIYD 150

Human    70 EIAYPLVEGVTEGYNGTIFAYGQTGSGKSFTMQGLPDPPSQRGIIPRAFE--------------- 119
            ....|   .:.|....||..||.:||||::|:.|   ...:.||||||.|
  Fly   151 TCVGP---KIMEEECVTIMTYGTSGSGKTYTLLG---DDVRAGIIPRALENIFTIYQDTVFRSPK 209

Human   120 -----------------------------------------------HVFESVQCAENTKFLVRA 137
                                                           |:||: :.:.:...||..
  Fly   210 LKLINGSIVFLQDDASLKELQIRKKLLDLCPDISAHHQRLKQVIDGDHMFET-KASTDVSVLVWV 273

Human   138 SYLEIYNEDVRDLLGADTKQKLELKEHPEKG---------VYVKGLSMHTVHSVAQCEHIMETGW 193
            |::|||||.|.|||....||. :|.|.|.|.         |::|||:...|.|..:...::..|.
  Fly   274 SFVEIYNELVYDLLAIPPKQD-KLGEVPRKNLKIVGNKGHVFIKGLTSVFVTSSEEALRLLRLGQ 337

Human   194 KNRSVGYTLMNKDSSRSHSIFTISIEMSAVDERGKDHLRAG-----KLNLVDLAGSERQSKTGAT 253
            :..:...|.:|.:|||||.:||:.|         ..:.|:|     .....|||||||.:.||.:
  Fly   338 QRSTYASTSVNANSSRSHCVFTVDI---------LKYNRSGITTQSSYKFCDLAGSERVNNTGTS 393

Human   254 GERLKEATKINLSLSALGNVISALVDGRCKH----VPYRDSKLTRLLQDSLGGNTKTLMVACLSP 314
            |.|||||..||.||..||..:.|....:.|.    :||||||||.|||.:|.|..|..|:..::|
  Fly   394 GLRLKEAKNINTSLMVLGRCLDAASTVQKKKNADIIPYRDSKLTMLLQAALLGKEKLAMIVTVTP 458

Human   315 ADNNYDETLSTLRYANRAKNIRNKPRINEDPKDALLREYQEEIKKLKAILTQQMSPSSLSALLSR 379
            .|..|:|.|:.|.:|:.||||
  Fly   459 LDKYYEENLNVLNFASIAKNI-------------------------------------------- 479

Human   380 QVPPDPVQVEEKLLPQPVI-QHDV------EAEKQLIREEYEERLARLKADYKAE-QESRARLEE 436
                        :..:||| ||.|      |..|....|         ..||..| ::...||:.
  Fly   480 ------------IFKEPVIKQHRVSYCGFMEFSKMSTCE---------GGDYTKELEDENVRLQL 523

Human   437 DITAMRNSYDVRLSTLEENLRKETEAVLQVGVLYKAEVMSRAEFASSAEYPPAFQYETVVKPKVF 501
            :|..::..:.:::..|||.||:|..|..|       |::...:          .|||...:.|:
  Fly   524 EIEQLKYDHVLQMQLLEEKLRRELTATYQ-------EIIQNNK----------KQYEDECEKKL- 570

Human   502 STTDTLPSDDVSKTQVSS---RFAELPKVEPSKSEISLGSSESSSLEETSVSEAFPGPEEPSNVE 563
                 |.:...|:..:||   |:.|  ::|..|.||                |....|  .|:.:
  Fly   571 -----LIAQRESEFMLSSQRRRYEE--QIEDLKDEI----------------EELKNP--ASDTD 610

Human   564 VSMPTEESRS 573
            :|....||:|
  Fly   611 ISDDPNESKS 620

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KIF17	XP_047282102.1	Motor_domain	4..335	CDD:473979	117/409 (29%)
sub	NP_611260.1	KISc	89..477	CDD:276812	115/407 (28%)
		GBP_C	<512..603	CDD:293879	28/131 (21%)
		coiled coil	576..586	CDD:293879	3/9 (33%)
		coiled coil	592..603	CDD:293879	5/26 (19%)