Protein Alignment KIF17 and Kif3C

DIOPT Version :10

• Sequence 1: XP_047282102.1
• Gene: KIF17 / 57576
• HGNCID: 19167
• Length: 1063
• Species: Homo sapiens
• Sequence 2: NP_651939.4
• Gene: Kif3C / 43820
• FlyBaseID: FBgn0039925
• Length: 649
• Species: Drosophila melanogaster
• Alignment Length: 923
• Identity: 294/923 - (31%)
• Similarity: 398/923 - (43%)
• Gaps: 340/923 - (36%)

Human     3 SEAVKVVVRCRPMNQRERELRCQPVVTVDCARAQCCIQNPGAADEPPKQFTFDGAYHVDHVTEQI 67
            ||.:|||||||||||.|:|..||.:|.::  .....:.||.|.....|:|.||..|::...||.|
  Fly     2 SENIKVVVRCRPMNQTEKERNCQNIVEIN--EFAVSVTNPSARISQQKKFIFDSVYNMKTDTEVI 64

Human    68 YNEIAYPLVEGVTEGYNGTIFAYGQTGSGKSFTMQGLPDPPSQRGIIPRAFEHVFESVQCAENTK 132
            |:|:.|.|||...||||||||||||||.||:.||||..:..:..||||:.|:|:||.:....|.:
  Fly    65 YDEMCYSLVESTIEGYNGTIFAYGQTGCGKTHTMQGDENFSNSTGIIPKCFDHIFERISMTTNVR 129

Human   133 FLVRASYLEIYNEDVRDLLGADTKQKL---ELKEHPEKGVYVKGLSMHTVHSVAQCEHIMETGWK 194
            :|...:|||||||.:||||..:....:   .|||.|..||.|..|:...|.:..||...:..|.|
  Fly   130 YLALVTYLEIYNERIRDLLNKNENTNVINHFLKELPGIGVSVPTLTTQPVVNANQCYDWLHFGNK 194

Human   195 NRSVGYTLMNKDSSRSHSIFTISIEMSA-VDERGKD---HLRAGKLNLVDLAGSERQSKTGATGE 255
            ||....|||||:|||||:||||::|.|. ::..|.|   .:..|||:||||||||||.||||.|:
  Fly   195 NRVTAATLMNKNSSRSHTIFTITLEQSPFLNSIGSDAFGGICRGKLSLVDLAGSERQRKTGAQGD 259

Human   256 RLKEATKINLSLSALGNVISALVDGRCKHVPYRDSKLTRLLQDSLGGNTKTLMVACLSPADNNYD 320
            |||||::|||||||||||||:||||:.||||:|||||||||||||||||||||::|:||.|.:||
  Fly   260 RLKEASQINLSLSALGNVISSLVDGKAKHVPFRDSKLTRLLQDSLGGNTKTLMISCISPTDIHYD 324

Human   321 ETLSTLRYANRAKNIRNKPRINEDPKDALLREYQEEIKKLKAILTQQMSPSSLSALLSRQVPPDP 385
            ||:||||||:|||||.|||:||||||||.||:||.||..||.:|.:...      ::::...|:
  Fly   325 ETISTLRYASRAKNISNKPKINEDPKDARLRQYQNEILYLKRMLQESQQ------IINKNNDPN- 382

Human   386 VQVEEKLLPQP--VIQHDVEAEKQLIREEYEERLARLKADYKAEQESRARLEEDITAMRNSYDVR 448
                 |::..|  :|||                                      |.|.::.:|:
  Fly   383 -----KIIKSPLKIIQH--------------------------------------TNMNSTKNVQ 404

Human   449 LSTLEENLRKETEAVLQVGVLYKAEVMSRAEFASSAEYPPAFQYETVVKPKVFSTTDTLPSDDVS 513
            :
  Fly   405 I---------------------------------------------------------------- 405

Human   514 KTQVSSRFAELPKVEPSKSEISLGSSESSSLEETSVSEAFPGPEEPSNVEVSMPTEESRSRYFLD 578
                                |.||                      .|.:.|..|..|
  Fly   406 --------------------IDLG----------------------RNCKASFKTNNS------- 421

Human   579 ECLGQEAAGHLLGEQNYLPQEEPQEVPLQGLLGLQDPFAEVEAKLARLSSTVARTDAPQADVPKV 643
                      :|.:.|:...:..:||.||
  Fly   422 ----------ILTKPNFPLIQSKEEVQLQ------------------------------------ 440

Human   644 PVQVPAPTDLLEPSDARPEAEAADDFPPRPEVDLASEVALEVVRTAEPGVWLEAQAPVALVAQPE 708
                           ||
  Fly   441 ---------------AR------------------------------------------------ 442

Human   709 PLPATAGVKRESVGMEVAVLTDDPLPVVDQQQVLARLQLLEQQVVGGEQAKNKDLKEKHKRRKRY 773
                                              :|:.|:::.::|||:..:.:|||||..|| |
  Fly   443 ----------------------------------SRIDLIKRSLIGGERIHDFELKEKHMARK-Y 472

Human   774 ADERRKQLVA-ALQN---SDEDSGDWVLLNVYDSIQEEVRAKSKLLEKMQRKLRAAEVEIKDLQS 834
            |.:|....:| ||..   .|.|    :|...|.:|.:|:..|:..:.|.:.|::..|:|:.||.|
  Fly   473 AAQRHLSAIAIALSRVKCEDRD----LLQGHYATITQEIDIKNDYIRKCKEKIKMLEMEVSDLNS 533

Human   835 EFQLEKIDYLATIRRQERDSMLLQQLLEQVQPLIRRDCNYSNLEK------ILRESCWDEDNGFW 893
            ||||::.|||..||...|.....|||      .::...|....::      ||:.|.|::|...|
  Fly   534 EFQLDREDYLDEIRNLGRQVKFHQQL------FLKFSSNPGKFDRNWTPDTILQNSLWNDDLKMW 592

Human   894 KIPHPVITKTSLP 906
            :||...:.|  ||
  Fly   593 RIPESDLIK--LP 603

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KIF17	XP_047282102.1	Motor_domain	4..335	CDD:473979	190/337 (56%)
Kif3C	NP_651939.4	Motor_domain	3..339	CDD:473979	190/337 (56%)