Protein Alignment KIF17 and cana

DIOPT Version :10

• Sequence 1: XP_047282102.1
• Gene: KIF17 / 57576
• HGNCID: 19167
• Length: 1063
• Species: Homo sapiens
• Sequence 2: NP_001027247.1
• Gene: cana / 3771934
• FlyBaseID: FBgn0040233
• Length: 1931
• Species: Drosophila melanogaster
• Alignment Length: 1052
• Identity: 238/1052 - (22%)
• Similarity: 414/1052 - (39%)
• Gaps: 294/1052 - (27%)

Human     3 SEAVKVVVRCRPMNQRERELRCQPVVT----VDCARAQCCIQNPGAADEPPKQFTFDGAYHVDHV 63
            :.:::|.::.||         |:|.:|    |...|:   ||   .||...:.:.||..:.....
  Fly     6 ASSIQVCIKVRP---------CEPGLTSLWQVKEGRS---IQ---LADSHAEPYVFDYVFDEGAS 55

Human    64 TEQIYNEIAYPLVEGVTEGYNGTIFAYGQTGSGKSFTMQGLPDPPSQRGIIPRAFEHVFESVQCA 128
            .:::::.:|..:|....:|.||||||||||.|||::||.|....|   |::..|.:.:|:.:...
  Fly    56 NQEVFDRMAKHIVHACMQGSNGTIFAYGQTSSGKTYTMMGDEQNP---GVMVLAAKEIFQQISSE 117

Human   129 ENTKFLVRASYLEIYNEDVRDLLGADTKQKLELKEHPEKGVYVKGLSMHTVHSVAQCE----HIM 189
            ....||:|..|:|||||.:.|||   .|:..:||.| |.|..:  ::::...|:...|    ..:
  Fly   118 TERDFLLRVGYIEIYNEKIYDLL---NKKNQDLKIH-ESGNGI--VNVNCKESIVTSEDDLLRQL 176

Human   190 ETGWKNRSVGYTLMNKDSSRSHSIFTISIEMSAVDERGKDHLRAGKLNLVDLAGSERQSKTGATG 254
            ..|.|.|.||.|.||:.|||||:||.|.||....|....|.::...|:||||||||:........
  Fly   177 YMGNKERVVGETNMNERSSRSHAIFRIIIESRKSDHSDNDTVKQSVLSLVDLAGSEQVDPADHAS 241

Human   255 ERLKEATKINLSLSALGNVISAL---VDGRCKHVPYRDSKLTRLLQDSLGGNTKTLMVACLSPAD 316
                       ||....|::.:|   ||.  |...:|||||.|::..|||||..|.::..::|
  Fly   242 -----------SLMIFRNLVKSLSESVDS--KPNSFRDSKLPRIMLPSLGGNVLTSIICTITP-- 291

Human   317 NNYDETLSTLRYANRAKNIRNKPRINE-DPKDALLREYQEEIKKLKAILTQQMSPSSLSALLSRQ 380
            :..:|:.||:.:...||.||.||::.: |.:..::|:....|..||..|.::
  Fly   292 SFVEESSSTISFGTCAKKIRCKPQVCKIDSETTMMRQLDRGISMLKDKLAKK------------- 343

Human   381 VPPDPVQVEEKLLPQPVIQHDVEAEKQLIREEYEERLAR--LKA-------DYKAEQESRARLEE 436
                                .::.|.||:.:|.|.|:.|  ||.       ||:.::..|.   .
  Fly   344 --------------------KIKNESQLVLQELEGRIKRDMLKIVSSASLDDYRLQKRRRT---W 385

Human   437 DITAMRNSYDVRLSTLEE-------------NLRKETEAVLQVGVLYKAEVMSRAEFASSAEYPP 488
            .:||..:..|..:..|.|             ||.|  ....:.|:..||:.:.:
  Fly   386 TLTASGSEGDAPVLALPEPEESRLPRPSKLTNLPK--PLFQRRGIAPKAKGICK----------- 437

Human   489 AFQYETVVKPKVFST--TDTLP----------SDDVSKTQVSSRFAE-LPKVEPSKSEISLGSSE 540
                  .:|.|...|  .||:|          :..:....:|.::.| :|..:..::|||..::.
  Fly   438 ------TLKEKRLQTDNMDTMPGRAKQLGRETASRIPSVMMSKKYQESVPNCDAPQTEISALTAS 496

Human   541 SSSLEET---------SVSEAFPGPEEPSNVEVSM----PTEESRSRYFLDECLGQEAAGHLLGE 592
            :...:||         .:.|.....|..:...|::    .|.:::|:...:|.|..      :.|
  Fly   497 NQVAKETIEKYEEQVKRLKETIERLEMENGKAVNLGEQFETHKAKSKQMEEELLSS------ISE 555

Human   593 QNYLPQEEPQEVPLQGLLGLQDPFAEVEAKLARLSSTVARTDAPQADVPKVPVQVPAPTDLLEPS 657
            ::            ..::.||....|:...:.|.|    :.|..::..|:           ||.|
  Fly   556 KD------------STIVSLQQSLEELSRDVLRNS----KEDQMRSMCPE-----------LESS 593

Human   658 DAR------------PEAEAADDFPPRPEVD-LASEVALEVVRTAEPGVWLEAQAPVALVAQPEP 709
            ..|            |.|.|:.......:.| |.||:|...::       ||:.......|..|.
  Fly   594 CERICNKCLELERLLPLASASGLDSVACQFDQLRSEIAATRMK-------LESMLSTFSHASCEV 651

Human   710 LPATAGVKRESVGMEVAVLTDDPLPVVDQQQVL------ARLQLLEQQV-VGGEQAKNKDLKEKH 767
            ...|...||  :..:::...||...:.::...|      .:|.:...|| ....|.|...|::::
  Fly   652 SQKTTDCKR--LSEQISTAHDDFGQLQEKYNNLKHKWSSQKLAIDTMQVDYNTIQQKYLQLQDEY 714

Human   768 KRRKRYADERRKQLVAALQNSDEDSGDWVLLNVYDSIQEEVRAKSKLLE---------------- 816
            :..:..:||:.:||      .||:|.....:.......||:.  |:|||
  Fly   715 RHLELRSDEQCQQL------QDENSKLQAEIGTLKERVEEIH--SELLEVPNPDTHPEDMELQNQ 771

Human   817 KMQRKLRAAEVEIKDLQSEFQLEKIDYLATIR--------------------------------- 848
            :::::|...:.|..::|..::....:.::||:
  Fly   772 ELKKRLSKLQWEFDEIQLNYECLSNELMSTIQECDALREEHKQRTTNSDLESMKSSGVGTECSDP 836

Human   849 RQERDSMLLQQ---LLEQVQPLIRRDCNYSNLEKILRESCWDEDNGFWKIPHPVITKTSLPQFQL 910
            ..|.|:.||||   |.:.:|.:...|  ||...::...:..::|.             |:|..:|
  Fly   837 ENELDTDLLQQFTKLSKSIQQIELTD--YSGGRRLFIYNHAEQDQ-------------SVPSLKL 886

Human   911 GHRTNQPAKPLQ 922
               ..:|||.|:
  Fly   887 ---CLEPAKYLE 895

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KIF17	XP_047282102.1	Motor_domain	4..335	CDD:473979	111/341 (33%)
cana	NP_001027247.1	Motor_domain	8..310	CDD:473979	111/340 (33%)
		CCDC158	<505..>729	CDD:464943	47/271 (17%)
		SMC_prok_B	622..1285	CDD:274008	58/309 (19%)
		SMC_prok_B	1110..1875	CDD:274008