Protein Alignment KIF17 and Klp59D

DIOPT Version :10

• Sequence 1: XP_047282102.1
• Gene: KIF17 / 57576
• HGNCID: 19167
• Length: 1063
• Species: Homo sapiens
• Sequence 2: NP_611762.1
• Gene: Klp59D / 37674
• FlyBaseID: FBgn0034827
• Length: 729
• Species: Drosophila melanogaster
• Alignment Length: 517
• Identity: 156/517 - (30%)
• Similarity: 240/517 - (46%)
• Gaps: 66/517 - (12%)

Human     4 EAVKVVVRCRPMNQRERELRCQPVVTVDCARAQCCIQNPGAAD-----EPPKQFTFDGAYHVDHV 63
            :.:.|.||.|||:::|...:...::||..|.:....:.....|     |..| |.||..:..:..
  Fly   232 QQITVCVRKRPMSRKEENSKNLDIITVPSADSLIVHELRLKVDLTKFLEHHK-FRFDYTFDEECS 295

Human    64 TEQIYNEIAYPLVEGVTEGYNGTIFAYGQTGSGKSFTMQG-----LPDPPSQRGIIPRAFEHVFE 123
            ...:|:..|.||:..:.||.|.|.||||||||||:.||.|     :.|  ...||...|...|||
  Fly   296 NALVYDHTARPLIRTMFEGGNATCFAYGQTGSGKTHTMGGEFFGKVQD--CGTGIYAMAARDVFE 358

Human   124 SVQCAENTKF--LVRASYLEIYNEDVRDLLGADTKQKLELKEHPEKGVYVKGLSMHTVHSVAQCE 186
            .|...|..:.  .:..|:.|||...|.||| ...|..|.:.|...:.|.|.||:...|..|....
  Fly   359 EVSRPEYRQMGAKITCSFFEIYGTKVFDLL-LPNKPMLRVLEDARQQVVVVGLTEMPVTKVEDVL 422

Human   187 HIMETGWKNRSVGYTLMNKDSSRSHSIFTISIEMSAVDERGKDHLRAGKLNLVDLAGSERQSKTG 251
            .::|.|.|.|:.|.|..|..|||||::|.|::...  |..|..    ||.:.|||||:||.:.|.
  Fly   423 RLIEHGSKERTSGQTSANAKSSRSHAVFQIALHFP--DSWGPH----GKCSFVDLAGNERGADTQ 481

Human   252 ATGERLK-EATKINLSLSALGNVISALVDGRCKHVPYRDSKLTRLLQDSL--GGNTKTLMVACLS 313
            :...:.: |..:||.||.||...|.|| ..:..|:|:|.||||::|:||.  |...||.|:|.:|
  Fly   482 SADRQTRIEGAEINKSLLALKECIRAL-SRQSSHLPFRGSKLTQVLRDSFVGGKKNKTCMIAMIS 545

Human   314 PADNNYDETLSTLRYANRAKNI---------------RNKPRINEDPKDALL------REYQEEI 357
            |:.:..:.||:|||||:|.|.:               ...|.:||:.:..::      .|.::|.
  Fly   546 PSMSCVENTLNTLRYADRVKELIAKEDEHLQSVEGDGEKSPDLNEESEPEMMADEEGDEEPEDED 610

Human   358 KKLKAILTQQMS-------PSSLSALLSRQVPPDPVQVEEKLLPQPVIQHDVEAEKQLIREEYEE 415
            .:...|.:::.|       ..|.:..|:...|...|.::|     ...||.:..|.   .|.|..
  Fly   611 NQHLTISSEEASSYNNMSYDMSFNHTLNILGPSRNVDIQE-----VAEQHALLVEN---LETYAH 667

Human   416 RLARLKADYKAE---QESRARLEEDITAMRNSYDVRLS-TLEENLRKETEAVLQVGVLYKAE 473
            ...:||.|.:.|   |.|.:.|.:.:..:..:.||..: ..::.|::|.:...:.|.|.::|
  Fly   668 NFRQLKTDKEIEQYTQNSESALMKLLAMVNRTRDVTHNYNTQKLLKEENQNAYKKGELDESE 729

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KIF17	XP_047282102.1	Motor_domain	4..335	CDD:473979	125/345 (36%)
Klp59D	NP_611762.1	KISc_KIF2_like	233..565	CDD:276818	124/342 (36%)