Protein Alignment KIF17 and Khc-73

DIOPT Version :10

• Sequence 1: XP_047282102.1
• Gene: KIF17 / 57576
• HGNCID: 19167
• Length: 1063
• Species: Homo sapiens
• Sequence 2: NP_001261000.1
• Gene: Khc-73 / 36718
• FlyBaseID: FBgn0019968
• Length: 1957
• Species: Drosophila melanogaster
• Alignment Length: 1270
• Identity: 315/1270 - (24%)
• Similarity: 505/1270 - (39%)
• Gaps: 368/1270 - (28%)

Human     1 MASEAVKVVVRCRPMNQRERELRCQPVVTVDCARAQCCIQNPGAAD----EPPKQFTFDGAYHVD 61
            |||:.:||.||.||.|:||.||..:.:|.::  :.|..:|||...:    :.||.|.||..::..
  Fly     1 MASDKIKVAVRVRPFNRREIELDTKCIVEME--KQQTILQNPPPLEKIERKQPKTFAFDHCFYSL 63

Human    62 H-------VTEQIYNEIAYPLVEGVTEGYNGTIFAYGQTGSGKSFTMQGLPDPPSQRGIIPRAFE 119
            :       ..|.:::.:...:::...:|||..||||||||||||:||.|..:   .:|||||..:
  Fly    64 NPEDENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQE---SKGIIPRLCD 125

Human   120 HVFESV--QCAENTKFLVRASYLEIYNEDVRDLLG-ADTKQKLELKEHPEKGVYVKGLSMHTVHS 181
            .:|.::  :......:.|..||:|||||.|.|||. ...||.|:::||...|.||.|||...|.|
  Fly   126 QLFSAIANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYVDGLSQLAVTS 190

Human   182 VAQCEHIMETGWKNRSVGYTLMNKDSSRSHSIFTISIEMSAVDE-RGKDHLRAGKLNLVDLAGSE 245
            ....:::|..|.|:|:|..|.||.:|||||::|::.:.....|: .|....:..:::||||||||
  Fly   191 YQDIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEKVSRMSLVDLAGSE 255

Human   246 RQSKTGATGERLKEATKINLSLSALGNVISALVD-------GRCKHVPYRDSKLTRLLQDSLGGN 303
            |..||||.|:||||.:.||.||:.||.|||.|.|       |..|.||||||.||.||:|:||||
  Fly   256 RAVKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVLTWLLKDNLGGN 320

Human   304 TKTLMVACLSPADNNYDETLSTLRYANRAKNIRNKPRINEDPKDALLREYQEEIKKLKAILTQQM 368
            ::|:|||.:||:.:||:|||||||||:|||.|.|...:||||...::||.:.|::.|:::|
  Fly   321 SRTVMVATISPSADNYEETLSTLRYADRAKRIVNHAVVNEDPNARIIRELRHEVETLRSML---- 381

Human   369 SPSSLSALLSRQVPPDPV-QVEEKLLPQPVIQHDVEAEKQL--IREEYEERLARLKADYKAEQES 430
                      :.....|| .|::||         .|:|..:  |.:.:||:|.:.:   :.:.|.
  Fly   382 ----------KHATGSPVGDVQDKL---------AESENLMKQISQTWEEKLVKTE---RIQNER 424

Human   431 RARLEE--------DITAMRNSY-----------------------------------DVRLSTL 452
            :..||:        .|...:|.|                                   |::||.|
  Fly   425 QQALEKMGISVQASGIKVEKNKYYLVNLNADPSLNELLVYYLKDRTLIGGRTISGQQPDIQLSGL 489

Human   453 EENLRKETEAV-LQVGVLYKAEVMSRAEF---ASSAEYPPA----------FQYETVVKPKVFST 503
              .::.|...: ::...||...|.....|   :::.|..|.          ..:..|..||..:|
  Fly   490 --GIQPEHCVITIEDSGLYMEPVQGARCFVNGSAAVEKTPLQNGDRILWGNHHFFRVNSPKSNNT 552

Human   504 T-------------------DTLPSDDVSKTQVSSRFAELPK---------VEPSKSEISLGSSE 540
            :                   |.:..:::|...:.:..|.|.:         :|..:.|......:
  Fly   553 SMCASEPQTPAQLIDYNFARDEIMQNELSNDPIQTAIARLERQHEEDKQVALEKQRQEYERQFQQ 617

Human   541 SSSLEETSVSEAFPGPEEP---SNVEVSMPTEESRSRYFLDE-------CLGQ-----EAAGHLL 590
            ..::...|...|...|.:|   ..:..:.||.:.|...:..|       .|||     ..|..|:
  Fly   618 LRNILSPSTPYAPYAPYDPLRMGKITPNTPTSQMRVEKWAQERDEMFRRSLGQLKTDIMRANSLV 682

Human   591 GEQNYLPQEEPQEVPLQGLLGLQDPFAEVEAKLARLSSTVARTDAPQADVPKVPVQVPAPTDLLE 655
            .|.|:|.:|                 .|.:.|.:                  |.:|:| |.:|
  Fly   683 QEANFLAEE-----------------MEKKTKFS------------------VTLQIP-PANL-- 709

Human   656 PSDARPEAEAADDFPPRPEVDLASEVALEVVRT-AEPGVWLEAQAPVALV--------------- 704
                         .|.|......||.|:.|.|| :...:|...:....|:
  Fly   710 -------------SPNRRRGAFVSEPAILVKRTNSGSQIWTMEKLENKLIDMREMYQEHKERVLN 761

Human   705 ------AQPEP----------LPATAGVKRESVGMEVAVLTDDPLPVVDQQ-QVLARLQLLEQQV 752
                  |:|:.          |...|.:..|.:..:|.:  |...|::.|| :|..||| :|.:.
  Fly   762 GLDEDNAKPQDPFYESQENHNLIGVANIFLEVLFHDVKL--DYHTPIISQQGEVAGRLQ-VEIER 823

Human   753 VGGEQAKNKDLKEKHKRRKRYADERRKQLVAALQNSDEDSGDWVLLNVYD------SIQEEVRAK 811
            :.|:..:::                   :..::..|..||.|     .||      |.|...|..
  Fly   824 IAGQMPQDR-------------------MCESVSESSGDSRD-----EYDDPVDPTSNQITCRVT 864

Human   812 SKLL--------------------EKMQRKLRAAEVEIKDLQSEFQLEKI-DYLATIRRQERDSM 855
            .|..                    ::|...:..||....|....|:.|.. |:..||..:..:..
  Fly   865 IKCASGLPLSLSNFVFCQYTFWGHQEMVVPVINAESTAHDQNMVFKFEHTQDFTVTINEEFLEHC 929

Human   856 L-----------------------LQQLLEQVQPLIRRDCNYSNLEKILRESCWDE-----DNGF 892
            :                       ::|...:.:.|:.|   ::.|.:  :...|.|     |||.
  Fly   930 IEGALSIEVWGHRSAGFSKTKGWEVEQQQAKARSLVDR---WAELSR--KIELWVEIHELNDNGE 989

Human   893 WKIPHPV-------ITKTSLPQFQLG--HRTNQPAKPLQQT----MASRTWRTTATGSCSVGATV 944
            :.   ||       :....:.|.:.|  .|.|...||:|.:    :..::....|.||.:|.:.:
  Fly   990 YS---PVEVTNRNEVLTGGIYQLRQGQQRRVNVRVKPVQNSGTLPIICQSIVNVAIGSVTVRSRL 1051

Human   945 KTLPATT---SDLSGPARSSAQTPGRASHITTR-----------------HQASAAHSATTLPSH 989
            :. |..:   .||:......::..||......:                 .:.|..|...:| :.
  Fly  1052 QR-PLDSYQEEDLTVLREKWSEALGRRRQYLDQQIQMLIKKEEKNEQERERELSLVHQWVSL-TE 1114

Human   990 PPRPLKCPSPGPSASSPSTSLSPRPSSPHPCPPVL 1024
            ....:..|:||........|..| ||...|..|||
  Fly  1115 ERNAVLVPAPGSGIPGAPASWEP-PSGMEPHVPVL 1148

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KIF17	XP_047282102.1	Motor_domain	4..335	CDD:473979	153/352 (43%)
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	155/359 (43%)
		Kinesin_assoc	356..468	CDD:465047	26/137 (19%)
		FHA_KIF13	446..547	CDD:438758	13/102 (13%)
		KIF1B	741..786	CDD:463574	4/44 (9%)
		DUF3694	989..1243	CDD:463599	32/166 (19%)
		CAP_GLY	1785..1850	CDD:460154