Protein Alignment TRMT5 and CG32281

DIOPT Version :9

• Sequence 1: NP_001337182.1
• Gene: TRMT5 / 57570
• HGNCID: 23141
• Length: 537
• Species: Homo sapiens
• Sequence 2: NP_728821.2
• Gene: CG32281 / 317953
• FlyBaseID: FBgn0052281
• Length: 457
• Species: Drosophila melanogaster
• Alignment Length: 469
• Identity: 192/469 - (40%)
• Similarity: 285/469 - (60%)
• Gaps: 26/469 - (5%)

Human    76 IFLLGQRKRFSTMPETETH---ERETELFSPPSDVRGMTKLDRTAFKKTVNIPVLKVRKEIVSKL 137
            :|::.:.|..:.:.....|   ..:.:...|||.||||.:|.|..|:|.|.:|.|:|.:..|.::
  Fly     1 MFIVSRLKDLTIITNRLRHYFRNMDVKELQPPSSVRGMQELQREQFRKIVQVPRLRVPESQVQRV 65

Human   138 MRSLKRAALQRPGIR--RVIEDPEDKESRLIMLDPYKIFTHDSFEKAELSVLEQLNVSPQISKYN 200
            |..:|:..|:...:.  |.::     :||.|:|.|..:...||....:|. .:::| :...|..:
  Fly    66 MPLVKKFLLKMEHLHPVRAVD-----QSREILLHPTPVKNWDSLPTEDLQ-RQKVN-AENFSFAD 123

Human   201 LELTYEHFKSEEILRAVLPEGQDVTSGFSRIGHIAHLNLRDHQLPFKHLIGQVMIDKNPGITSAV 265
            |||.||::.:.|||::|||..::..:.:||||||||||||||.||:|.|||||:.||.|...:.|
  Fly   124 LELRYENWSANEILKSVLPTEEEGLTSYSRIGHIAHLNLRDHLLPYKQLIGQVLRDKLPNCRTVV 188

Human   266 NKINNIDNMYRNFQMEVLSGEQNMMTKVRENNYTYEFDFSKVYWNPRLSTEHSRITELLKPGDVL 330
            ||.::|||.|||||:|::.|:.:...:.:||...:|||||||||||||||||.||.::||..|||
  Fly   189 NKASSIDNTYRNFQLELICGDPDYQVETKENGVPFEFDFSKVYWNPRLSTEHERIVKMLKSDDVL 253

Human   331 FDVFAGVGPFAIPVAKKNCTVFANDLNPESHKWLLYNCKLNKVDQKVKVFNLDGKDFLQGPVKEE 395
            :|||||||||:||.|||.|.|.||||||||.:||.:|.|.||....:|:.|.||:.|:...::|:
  Fly   254 YDVFAGVGPFSIPAAKKRCHVLANDLNPESFRWLQHNAKRNKCLPNIKMSNKDGRQFIVEELRED 318

Human   396 LMQLLGLSKERKPSVHVVMNLPAKAIEFLSAFKWLLD----GQPCSSEFLPIVHCYSFSKDANPA 456
            |::.|..:......:|:.|||||.|:|||.||:.|..    .|..::...|.||.|||:|..|..
  Fly   319 LLKRLCTTDTTTYGIHITMNLPAMAVEFLDAFRGLYSADELAQLPTNVCYPTVHVYSFAKGENTK 383

Human   457 EDVRQRAGAVLGISLE--ACSSVHLVRNVAPNKEMLCITFQIPASVLYKNQTRNPENHEDPPLKR 519
            |.|||...:.||.||:  ....::.||||||||:|..::|::..::|        ...::..:.|
  Fly   384 ELVRQLVESNLGASLDENLLQGINFVRNVAPNKDMYRVSFKLSLNML--------TTLKEVEVTR 440

Human   520 QRTAEAFSDEKTQI 533
            :|.||...:..|::
  Fly   441 KRYAEEELEVATKV 454

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TRMT5	NP_001337182.1	Met_10	125..497	CDD:332667	171/379 (45%)
CG32281	NP_728821.2	Met_10	149..353	CDD:280612	114/203 (56%)
		AdoMet_MTases	224..>313	CDD:302624	59/88 (67%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141913
Domainoid	1	1.000	239	1.000	Domainoid score	I2292
eggNOG	1	0.900	-	-		E1_COG2520
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6096
Inparanoid	1	1.050	337	1.000	Inparanoid score	I2396
Isobase	1	0.950	-	0	Normalized mean entropy	S1922
OMA	1	1.010	-	-		QHG54511
OrthoDB	1	1.010	-	-		D532693at33208
OrthoFinder	1	1.000	-	-		FOG0002786
OrthoInspector	1	1.000	-	-		oto90456
orthoMCL	1	0.900	-	-		OOG6_100981
Panther	1	1.100	-	-	LDO	PTHR23245
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1549
SonicParanoid	1	1.000	-	-		X2185
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750