Protein Alignment ARRDC3 and CG18747

DIOPT Version :10

• Sequence 1: NP_065852.1
• Gene: ARRDC3 / 57561
• HGNCID: 29263
• Length: 414
• Species: Homo sapiens
• Sequence 2: NP_652650.2
• Gene: CG18747 / 59143
• FlyBaseID: FBgn0042104
• Length: 418
• Species: Drosophila melanogaster
• Alignment Length: 436
• Identity: 117/436 - (26%)
• Similarity: 201/436 - (46%)
• Gaps: 63/436 - (14%)

Human     6 VKSLTISFDCLNDSNVPVYSSGDTVSGRVNLEVTGEIRVKSLKIHARGHAKVRWTESRNAGSNTA 70
            |.:..||||  |:.:...| :|..|.|...|:......|:::.:...|::..:|:| ::.||
  Fly     2 VVTCEISFD--NNKHGTFY-AGQLVKGCATLKCDRSKEVQAVLLKVVGYSITKWSE-KSLGS--- 59

Human    71 YTQNYTEEVEYFNHKDILIGHERDDDNSEEGFHTIHSGRHEYAFSFELP-QTPLATSFEGRHGSV 134
             |:.|....:|.:....|:|.|:::.::.....||.:|.|.|.|:.:|| |.|  :|||||||.:
  Fly    60 -TKLYVGREDYLSSNTYLVGSEQNNTHNNTHRLTIEAGVHSYNFTCQLPYQCP--SSFEGRHGCI 121

Human   135 RYWVKAELHRPWLLPVKLKKEFTVFEHIDIN--TPSLLSPQAGTKEKTLCCWFCTSGPISLSAKI 197
            ||.||..|.|||.......|.|||.:.:|:|  ||.|.|.......:|.||..|.:.|:.|...:
  Fly   122 RYIVKVLLIRPWKFDQAYTKGFTVLKMLDLNFDTPQLKSAAHSEGYRTFCCGPCKTDPLKLELHL 186

Human   198 ERKGYTPGESIQIFAEIENCSSRMV--VPKAAIYQTQAFYAKGKMKEVKQL-VANLRGESL--SS 257
            .:.||.||:.|.:...:.|.::..|  :..:.:...:.:....:...|::| ::..:|||:  ..
  Fly   187 PQAGYVPGQKIPVTIVVVNNTAVAVSEIRLSLVMLVRYYSVSPEHSRVERLIISRAKGESVLKQC 251

Human   258 GKTETWNGKLLKIPPVSPSILDCS-IIRVEYSLMVYVDIPGAMD-LFLNLPLVIGTIPLHPFGSR 320
            .:::|.:   |.:|...|:.::.| :|::.|.|.|...:....: ..:.:|:.:|||||...|
  Fly   252 TRSQTID---LPVPSTPPTCVELSNLIQIAYQLEVEALVKSLREQQLMVMPVTVGTIPLAVSG-- 311

Human   321 TSSVSSQCSMNMNWLSLSLPERPEA----------PPSYAEVVTE-EQRRNNLAPV---SACDDF 371
                          :.:..|.|..|          ||....:||. |...::||..   ||..::
  Fly   312 --------------IVVQQPPRRSAHYEGPDSRRNPPDELPMVTALESLPSDLASSAADSALPNY 362

Human   372 ERAL--------QGPLFAY-IQEFRFLPPPLYSEIDPNPDQSADDR 408
            |.:.        :..|.|: ..||..| .|:||...|.|..:|:.|
  Fly   363 EESRHTQRGNINEEELHAFGSNEFAPL-YPVYSIPSPTPVLTANAR 407

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ARRDC3	NP_065852.1	Arrestin_N	22..165	CDD:425619	47/143 (33%)
		Arrestin_C	187..314	CDD:214976	27/133 (20%)
		PPxY motif 1. /evidence=ECO:0000305	346..349		2/2 (100%)
		PPxY motif 2. /evidence=ECO:0000305	391..394		1/2 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	393..414		6/16 (38%)
CG18747	NP_652650.2	Arrestin_N	5..152	CDD:425619	52/156 (33%)
		Arrestin_C	176..307	CDD:214976	27/133 (20%)