Protein Alignment ARRDC3 and CG18746

DIOPT Version :10

• Sequence 1: NP_065852.1
• Gene: ARRDC3 / 57561
• HGNCID: 29263
• Length: 414
• Species: Homo sapiens
• Sequence 2: NP_652649.1
• Gene: CG18746 / 59142
• FlyBaseID: FBgn0042103
• Length: 438
• Species: Drosophila melanogaster
• Alignment Length: 431
• Identity: 99/431 - (22%)
• Similarity: 183/431 - (42%)
• Gaps: 80/431 - (18%)

Human    15 CLNDSNVPVYSSGDTVSGRVNLEVTGEIRVKSLKIHARGHAKVRWTESRNAGSNTAYTQNYTEEV 79
            |.|...  ::.:|..:||:|.::...|..||::.::.:|:|:..|.::.:...:.:..:::...|
  Fly     9 CNNSQG--IFYAGQLISGQVVIKTEKEKSVKAVILNIKGYAETHWADTEHDPDDQSNGESFNGHV 71

Human    80 EYFNHKDILIGHERDDDNSEEGFHTIHSGRHEYAFSFELPQTPLATSFEGRHGSVRYWVKAELHR 144
            :|...:..|.|    ..:|.|..  |..|...|.|:.:||.| ..:||||..|.:||.|.....|
  Fly    72 DYLATRAYLHG----SSSSIEVL--IEPGTSSYRFACQLPIT-CPSSFEGTLGRIRYLVNVRFVR 129

Human   145 PWLLPVKLKKEFTVFEHIDINTPSLL--SPQAGTKEKTLCCWFCTSGPISLSAKIERKGYTPGES 207
            ||...:...:.|||.:.:|:|:.||:  .|.....::|.||:.|.|.|:|:...:.:.|:.||:.
  Fly   130 PWKFDLNFNRCFTVIKVMDLNSESLMLRVPSQVESQRTFCCFPCRSSPLSMRLSVPQSGFVPGQI 194

Human   208 IQIFAEIENCSSRMV------VPKAAIYQTQAFYAKGKMKEVKQLVANLRGESLSSGKTETWNGK 266
            :.:...:.|.|...|      :....||.:|...|.......:.::....|.|....:..|::
  Fly   195 VPVEVMVSNDSGVAVEDITVKLTMVVIYYSQPPSADTNKDRFEMVLKTGGGVSTKCRQQFTFD-- 257

Human   267 LLKIPPVSPSILD-CSIIRVEYSLMVYVDIPGAM-DLFLNLPLVIGTIPLHPFGSRTSSVSSQCS 329
             ||:||..|:..: ||||::.|.:.....:.|.. ...|::|:.||::||      |..:..:
  Fly   258 -LKVPPTPPTCFNLCSIIQIGYQVEAEARVKGCHGGQSLHMPITIGSVPL------TKQLQKE-- 313

Human   330 MNMNWLSLSLPERPE----------------------------APPSYAEV---------VTEEQ 357
             ...|..:..|::.:                            |||||||.         .::.:
  Fly   314 -PRTWGEVLPPQQLDAKALILIGSEQNGEALGSPNPWAADPSIAPPSYAEAKHISPDPHKFSKSK 377

Human   358 RRNNLAPVSACDDFERALQGPLFAYIQEFRFLPPPLYSEID 398
            :::....|....  ||..:..:|:          |||:..|
  Fly   378 KKSQKRGVKGSQ--ERKAETIVFS----------PLYAVFD 406

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ARRDC3	NP_065852.1	Arrestin_N	22..165	CDD:425619	38/142 (27%)
		Arrestin_C	187..314	CDD:214976	31/134 (23%)
		PPxY motif 1. /evidence=ECO:0000305	346..349		2/2 (100%)
		PPxY motif 2. /evidence=ECO:0000305	391..394		1/2 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	393..414		3/6 (50%)
CG18746	NP_652649.1	Arrestin_N	4..150	CDD:425619	40/149 (27%)
		Arrestin_C	174..306	CDD:214976	31/134 (23%)